舌下含服尘螨滴剂治疗变应性鼻炎停药1年后的疗效分析

邱婷; 陶泽璋; 许昱

doi:10.13201/j.issn.1001-1781.2016.09.013

舌下含服尘螨滴剂治疗变应性鼻炎停药1年后的疗效分析

- 武汉大学人民医院耳鼻咽喉头颈外科(武汉, 430060)
基金项目:
国家自然科学基金（No：81371070）；湖北省自然科学基金（No：2014CKB495）

详细信息

通讯作者: 许昱,E-mail:xy37138@163.com

中图分类号: R765.21

收稿日期: 2016-04-08

Analysis of the efficacy of specific immunotherapy of allergic rhinitis after withdrawal of dust mites drops in about one year

- Department of Otolaryngology-Head and Neck Surgery, Renmin Hospital of Wuhan University, Wuhan, 430060, China

More Information

Corresponding author: XU Yu, E-mail: xy37138@163.com

Received Date: 08 April 2016

摘要

摘要: 目的：分析舌下含服尘螨滴剂治疗变应性鼻炎（AR）停药1年后的疗效及相关影响因素。方法：收集武汉大学人民医院2007-06-2011-12期间收治的87例诊断明确的粉尘螨过敏AR患者。以症状评分为标准，用有效与无效来评估疗效，用Logistic回归分析舌下免疫治疗的疗效及相关影响因素。结果：在87例患者中，治疗有效率为54.0%（47/87）；坚持用药1年的患者有36例，依从率为41.4%；共7例出现不良反应（均为Ⅰ级）。Logistic回归分析显示，疗效与用药时间有关（P<0.05），与性别、年龄无关（P>0.05）。治疗时间<3个月者有效率为41.9%，3~12个月者有效率为70.0%，>12~18个月者有效率为37.5%，>18个月者有效率为70.0%。结论：粉尘螨滴剂的长期疗效与治疗时间呈正相关，但治疗12~18 个月时会有反复现象；医生应督促患者坚持治疗并及时处理并发症，从而有效提高有效率和改善患者的生活质量。
- 鼻炎,变应性 /
- 粉尘螨滴剂 /
- 特异性免疫治疗
Abstract: Objective: To analyze the validity and related factors of sublingual immunotherapy of allergic rhinitis after withdrawal of dust mites drops in about one year.Method: In Renmin Hospital of Wuhan University 87 patients with allergic rhinitis whose allergen for dust mites from June 2007 to December 2011 were retrospectively analysed. The effect of sublingual immunotherapy and its related factors were evaluated by the symptoms and signs. The data was analysed by Logistic regression.Result: The response rate of samples is 54.0%. There are 36 patient having been treating over one year,the compliance rate is 41.4%. By using logistic regression results are as follows. The efficacy is related with treatment time(P<0.05),not are gender and age(P>0.05). When treatment time is less than 3 months,the validity is 41.9%. The validity of 3-12 months is 70.0%,The one of >12-18 months is 37.5%, The one of more than 18 months is 70.0%.Conclusion: The long-term efficacy of dust mites drops is positive correlation with time. But in 12-18 months condition can be waving. So clinician should supervise and urge patients and treat the adverse reactions properly, which can improve the effect of desensitization therapy and quality of life.
- rhinitis, allergic /
- dust mites drops /
- specific immunotherapy

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