天津地区变应性鼻炎患儿食物性变应原血清特异性IgE含量的临床分析

李亮; 郎媛媛; 张嘉懿; 沈蓓

doi:10.13201/j.issn.1001-1781.2016.09.012

天津地区变应性鼻炎患儿食物性变应原血清特异性IgE含量的临床分析

- 1. 天津市儿童医院耳鼻咽喉科(天津, 300074);
- 2. 天津市儿童医院检验科

详细信息

通讯作者: 李亮,E-mail:liliang_729@163.com

中图分类号: R765.21

收稿日期: 2016-01-22

Clinical analysis of food serum specific IgE in children with allergic rhinitis in Tianjin

- 1. Department of Otorhinolayngology, Tianjin Children's Hospital, Tianjin, 300074, China;
- 2. Department of Clinical Laboratory, Tianjin Children's Hospital

More Information

Corresponding author: LI Liang, E-mail: liliang_729@163.com

Received Date: 22 January 2016

摘要

摘要: 目的：分析天津地区变应性鼻炎（AR）患儿食物性变应原血清特异性IgE含量的检测结果，了解AR患儿常见食物性变应原的种类及其分布规律。方法：应用德国Mediwiss公司敏筛变应原检测系统（Allergy Screen）测定血清中相应变应原的特异性IgE。根据性别、年龄、季节分组，描述食物性变应原的分布特征。结果：天津地区AR患儿最常见的食物性变应原为牛奶（17.28%），其次是鸡蛋清（13.79%）、螃蟹（9.56%）、腰果（8.64%）等。食物组阳性率（25.56%）明显低于吸入组（57.17%），差异有统计学意义（P<0.05）；单纯吸入组阳性者316例，食物组与吸入组同时阳性者194例，单纯食物组阳性者34例；分组研究显示，不同年龄组的食物性变应原阳性率分布差异有统计学意义（P<0.01）；不同性别、季节组的食物性变应原分布总阳性率差异无统计学意义（P>0.05）；腰果、牛肉变应原阳性率在不同性别之间分布不同；苋、鸡蛋清、牛奶、螃蟹变应原阳性率在不同年龄组中分布不同，差异有统计学意义（P<0.05）。结论：牛奶、鸡蛋清、螃蟹、腰果是天津地区AR患儿最常见的食物性变应原；单纯食物过敏较为少见，食物过敏通常伴有吸入性物质过敏；腰果变应原阳性率男性大于女性，女性患儿牛肉过敏阳性率明显大于男性；随着年龄增长，苋变应原的阳性率明显升高，而鸡蛋清、牛奶、螃蟹变应原的阳性率明显下降。
- 儿童 /
- 鼻炎,变应性 /
- 特异性IgE /
- 变应原 /
- 食物
Abstract: Objective: To define the common food allergens in children with allergic rhinitis in Tianjin with detection of serum specific immunoglobulin E(IgE) against foods and inhalation.Method: Mediwiss(Screen Allergy) was used to determine serum specific IgE. The relationships between food allergy and gender, age, season were also analyzed.Result: Most common food allergens in children with AR in Tianjin are milk(17.28%), followed by egg white(13.79%), crab(9.56%) and cashew nuts(8.64%). Children in food-related allergy group were significantly less than that in the inhalation-related allergy group, the difference was statistically significant(P<0.05). Among food-related allergy group, one hundred and ninty four cases are both sensitive to food allergens and inhalation allergens, and the other 34 cases are only sensitive to food allergens. There were significant differences about the positive rate of allergy between different age groups(P<0.01).There was no significant difference in the total food allergens sensitivity rate between different gender and seasonal groups(P>0.05). The cashew and beef allergen sensitivity rates are different between male and female. The sensitivity rates of amaranth, egg, white milk, and crab are different among different age groups. The difference was statistically significant(P<0.05).Conclusion: Milk, egg, crab, cashew nuts are the most common food allergens in children with AR in Tianjin area. Only food-related allergy is rare, food allergies are usually accompanied by inhalation-related allergy. Cashew allergen sensitivity rate was higher in male than female. Milk allergen sensitivity rate was higher in female than male. Sensitivity rate of amaranth allergen increased significantly, while that of egg milk and crab allergen decreased significantly with age.
- child /
- rhinitis, allergic /
- specific IgE /
- allergen /
- food

HTML全文

参考文献(15)

[1]	中华耳鼻咽喉头颈外科杂志编委会鼻科组,中华医学会耳鼻咽喉头颈外科学分会鼻科学组、小儿学组,中华儿科杂志编辑委员会.儿童变应性鼻炎诊断和治疗指南(2010年,重庆)[J].中华耳鼻咽喉头颈外科杂志,2011,46(1):7-8.
[2]	ASHER M I,MONTEFORT S,BJORKSTEN B,et al.Worldwide time trends in the prevalence of symptoms of asthma,allergic rhinoconjunctivitis,and eczema in childhood:ISAAC Phases one and three repeat multicountry cross-sectional surveys[J].Lancet,2006,368:733-743.
[3]	KONG W J,CHEN J J,ZHENG Z Y,et al.Prevalence of allergic rhinitis in 3-6-year-old children in Wnhan of China[J].Clin Exp Allergy,2009,39:869-874.
[4]	陶金好,孔宪明,曹兰芳.上海地区儿童过敏性疾病食物变应原的研究[J].临床儿科杂志,2011,29(5):461-463.
[5]	宋国超,王雪艳,王峥,等.天津地区儿童血清特异性IgE变应原临床分析[J].天津医科大学学报,2014,20(6):477-479.
[6]	戴伟利,张杰,张亚梅.北京地区112岁儿童变应性鼻炎变应原谱分析[J].山东大学耳鼻喉眼学报,2014,28(1):39-45.
[7]	张蕾,艾涛,罗荣华.成都地区1123例儿童变应原皮肤点刺结果分析[J].海南医学,2014,25(23):3550-3552.
[8]	杨利桃,贾小莉,黄秋花.变应性鼻炎患者食物性变应原特异性IgE分析[J].国际检验医学杂志,2014,35(7):837-839.
[9]	SPERGEL J M,PALLER A S.Atopic dermatitis and the atopic march[J].J Allergy Immnol,2003,112:118-127.
[10]	徐静华,张广毓,钟天鹰,等.儿童过敏性鼻炎变应原检测分析[J].中国妇幼保健,2013,18(9):1442-1444.
[11]	DRWOREN M,PEAKE J.Cashew nut allergy is a ssociated with a high risk of anaphylaxis[J].Arch Dis Child,2005,90:1084-1085.
[12]	CLARKA T,ANAGNOSTOU K,EWAN P W.Cashew nut causes more severe reactions than peanut:casematched comparison in 141 children[J].Allergy,2007,62:913-916.
[13]	刘飞燕,贾梦阳,刘志刚,等.腰果主要变应原Anao2基因克隆及原核表达[J].中国公共卫生,2012,28(12):1589-1591.
[14]	罗嘉莹,黄惠敏,郑佩燕,等.广东省学龄前儿童食物过敏情况及相关危险因素分析[J].重庆医科大学学报,2013,38(8):843-845.
[15]	ERIKSSON J,BJERG A,LOTVALL J,et al.Rhinitis phenotypes correlate witn different symptom presentation and risk factor patterns of asthma[J].Respir Med,2011,105:1611-1621.