Abstract: Objective: To evaluate the perioperative analgesic effects of parecoxib sodium in patients undergoing nasal endoscopic surgery.Method: In the randomized, double blind, controlled study, 120 patients undergoing septoplasty were divided into 3 groups (n=40): A group received parecoxib at a dose of 40 mg by muscle injection 30 min before the operation followed by saline at the same volume every 24 h for 48 h;B group received parecoxib at a dose of 40 mg by muscle injection 30 min before the operation followed by 40 mg every 24 h for 48 h; C group received an equal volume of 0.9% saline at the same time points. Patients were assessed with respect to pain score (VAS),rescue analgesia requirement and the side effects during the operation as well as at 3,24,48 h after the surgery.Result: Intra-operative as well as the postoperative pain scores were less in the A group and B group than in the control group. Compared with group A, group B had significantly lower VAS score at 24 h after the operation, however there were no significant difference on other time points. Fewer participants of both the A and B groups required rescue medication after operation. Conclusion: Administration of parecoxib can provide ideal analgesic effects without serious adverse side effects at the perioperative period for patients who received nasal endoscopic operation. Intramuscular parecoxib (40 mg 30 min before the operation followed 40 mg qd for 48 h) designed as preoperative analgesia mode resulted in sufficient perioperative analgesia that deserves popularization in the clinical works.