DNA甲基化在甲状腺肿瘤中的研究进展

宋现运; 尚小领; 张玉妥

doi:10.13201/j.issn.1001-1781.2015.06.028

DNA甲基化在甲状腺肿瘤中的研究进展

- 1. 河北北方学院病原微生物与免疫学研究所(河北张家口, 075000);
- 2. 河北北方学院附属第一医院耳鼻咽喉头颈外科

详细信息

通讯作者: 尚小领,E-mail:xiaolingshang66@sina.com

中图分类号: R736.1

收稿日期: 2014-10-28

DNA methylation in thyroid carcinoma

More Information

Corresponding author: SHANG Xiaoling, E-mail: xiaolingshang66@sina.com

Received Date: 28 October 2014

摘要

- 甲基化 /
- 表观遗传学 /
- 甲状腺肿瘤
Abstract: Cancer has become clear that not merely gene variations but also epigenetic modifications may contribute to it.Epigenetic changes refer to stable alterations in gene expression with unrelated to changes in the underlying genetic sequence,resulting in heritable.DNA methylation is one of the common epigenetic changes.It control the gene expression through changing DNA conformation and stability,chromatin structer,DNA-protein interaction.The reversal of dysregulated DNA methylation has emerged as a potential strategy for the treatment of thyroid carcinoma.The artical will provide an overview of how DNA methylation contribute to thyroid carcinoma dissemination,invasion and metastasis and we will summarize the latest epigenetic therapies for thyroid carcinoma.
- methylation /
- epigenetic /
- thyroid carcinoma

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