Analysis of allergens spectrum in children with allergic rhinitis in Zhengzhou district
-
摘要: 目的: 分析郑州地区变应性鼻炎(AR)患儿主要变应原的分布特点,为其诊治及预防提供参考依据。方法: 应用20种标准化变应原试剂对412例拟诊为AR的患儿进行皮肤点刺试验(SPT),并对结果进行统计学分析。结果: 329例(79.85%)呈阳性反应,吸入性变应原以粉尘螨(87.54%,288/329)最高,其次为屋尘螨(86.32%,284/329)、猫上皮(62.31%,205/329)、真菌Ⅰ(47.72%,157/329)、狗上皮(43.16%,142/329)等;食入性变应原以小虾(13.68%,45/329)最高,其次为鸡蛋(5.17%,17/329)、鲤鱼(4.56%,15/329)、肉蛋白Ⅰ(3.04%,10/329)、牛奶(3.04%,10/329)等。结论: 尘螨、猫上皮、真菌Ⅰ、狗上皮是郑州地区儿童AR最主要的变应原,改善患儿居住环境,避免接触变应原至关重要。Abstract: Objective: To analyze the main allergens in children with allergic rhinitis and provide scientific basis for prevention and treatment in Zhengzhou district.Method: Twenty standardization allergens were used to perform skin prick test in 412 children with AR,and the results were statistically analyzed.Result: Three hundred and twenty-nine of 412 cases(79.85%) showed positive reaction. The positive rate of dermatophagoides farina (87.54%) was the highest in inhaled allergens, followed by dermatophagoides pteronyssinus (86.32%),cat hair(62.31%),fungus Ⅰ (47.72%) and dog hair (43.16%). The positive rate of shrimp (13.68%) was the highest in ingestive allergens,then egg (5.17%),carp (4.56%),meat Ⅰ (3.04%) and milk (3.04%).Conclusion: Dust mites,cat hair, fungus,dog hair were the most common allergens in children in Zhengzhou district. Improving living environment of children with AR and avoiding contacting with allergens were pretty important.
-
[1] AIT-KHALED N,PEARCE N,ANDERSON H R,et al.ISAAC Phase Three Study Group.Global map of the prevalence of symptoms of rhinoconjunctivitis in children:The International Study of Asthma and Allergies in Childhood(ISAAC)Phase Three[J].Allergy,2009,64:123-148.
[2] 中华耳鼻咽喉头颈外科杂志编辑委员会鼻科组,中华医学会耳鼻咽喉头颈外科学分会鼻科学组、小儿学组,中华儿科杂志编辑委员会等.儿童变应性鼻炎诊断和治疗指南(2010年,重庆)[J].中华耳鼻咽喉头颈外科杂志,2011,46(1):7-8.
[3] BOUSQUET J,KHALTAEV N,CRUZ A A,et al.Allergic Rhinitis and Its Impact on Asthma(ARIA)2008update(in collaboration with the World Health Organization,GA(2)LEN and AllerGen)[J].Allergy,2008,63(Suppl 86):8-160.
[4] 张迎宏,朱丽,张珂,等.血清特异性IgE检测与皮肤点刺试验在变应性鼻炎中的应用[J].临床耳鼻咽喉头颈外科杂志,2013,27(2):75-77.
[5] 王成硕,张罗,韩德民,等.北京地区变应性鼻炎患者吸入变应原谱分析[J].临床耳鼻咽喉科杂志,2006,20(5):204-207.
[6] 钟竹青,王芳,等.长沙地区562例变应性鼻炎患儿变应原谱分析[J].临床耳鼻咽喉头颈外科杂志,2011,25(17):774-776.
[7] ARLIAN L G,PLATTS-MILLS T A.The biology of dust mites and the remediation of mite allergens in allergic disease[J].J Allergy Clin Immunol,2001,107(3 Suppl):S406-413.
[8] 王泽海,林文森,李书彦,等.变应性鼻炎患病率及相关因素调查[J].中华耳鼻咽喉头颈外科杂志,2011,46(3):225-231.
[9] 杨珍,陈同辛,周纬,等.上海地区变应性疾病患儿真菌变应原反应特点[J].实用儿科临床杂志,2008,23(9):660-662.
[10] 胡海文,陈菲菲,李靖.广州地区1529例变应性鼻炎患者食入性变应原的研究与分析[J].临床耳鼻咽喉头颈外科杂志,2012,26(23):1083-1088.
[11] 赵晓明,林丽莉.1280例过敏性鼻炎食物不耐受检测结果分析[J].实验与检验医学,2010,28(3):212-220.
[12] LIAM C K,LOO K.Skin prick test reactivity to common aeroallergens in asthmatic patients with and without rhinitis[J].Respirology,2002,7:345-350.
计量
- 文章访问数: 30
- PDF下载数: 28
- 施引文献: 0