Abstract: Objective:To evaluate short term quality of life of patients with chronic rhinosinusitis by using Chinese version of the sinonasal outcome test-22 (SNOT-22) and to formulate an ideal therapy system for patients with chronic rhinosinusitis.Method:Using prospective randomized controlled design,we chose the SNOT-22 to evaluate and compare 78 CRS patients' quality of life (QOL) before surgery, at 1-month,3-month,6-month and 9-month after functional endoscopic sinus surgery(FESS). At the same time, we randomly chose 100 healthy controls to compare their QOL with those of CRS patients after FESS.Result:We found that except for 5 items (cough, ear expanding, otalgia, facail pain and weary), the grade of 17 other items of CRS patients were significantly higher than those of the healthy controls (P<0.05). There was no significant difference in 7 items (olfactory sensation, hypogeusis, backflow of nasal discharge, difficult to fall asleep, bad sleep, bad work efficiency, depression, embarrassment) at 3 months after FESS between chronic rhinosinusitis patients and healthy controls (P>0.05). There was no significant difference in 9 items (blow noses, sneeze, rhinorrhea, nasal discharge thickness, dizziness, night wake, tired of wake, attention deficit, sense of loss) at 6 months after FESS between chronic rhinosinusitis patients and healthy controls (P>0.05). There was no significant difference in nasal obstruction at 6 months after FESS between chronic rhinosinusitis patients and healthy controls (P>0.05), at this time the totle grade was normal (P>0.05). The recovery period of QOL in patients was about 9 months (P>0.05). The 5 great items were nasal obstruction, olfactory sensation, hypogeusis, nasal discharge, nasal discharge thickness and blow noses. There was no difference in items except for bad sleep replacing nasal discharge thickness between 1-month and 9-month after surgery.Conclusion:The Chinese vesion of SNOT-22 could evaluate QOL of CRS patients in this area. The recovery of QOL of CRS patients needs about 6 months after FESS,but problems of olfactory sensation, hypogeusis, nasal discharge and difficult to sleeep still needs to be resolved.