基质金属蛋白酶-1基因-1607位点多态性与亚洲人群头颈癌相关的Meta分析

陈向军; 余兹中; 郜元坤; 刘国磊; 田磊; 李国义

doi:10.13201/j.issn.1001-1781.2014.21.014

基质金属蛋白酶-1基因-1607位点多态性与亚洲人群头颈癌相关的Meta分析

- 湖北医药学院附属太和医院耳鼻咽喉头颈外科(湖北十堰, 442000)

详细信息

通讯作者: 陈向军,E-mail:cxjsh7211@163.com

中图分类号: R739.6

收稿日期: 2014-03-17

Meta-analysis of association between MMP-1-1607 polymorphism and head and neck cancer risk in asia population

- Department of Otorhinolaryngology-Head and Neck Surgery, Taihe Hospital, Hubei University of Medicine, Shiyan, 442000, China

More Information

Corresponding author: CHEN Xiangjun, E-mail: cxjsh7211@163.com

Received Date: 17 March 2014

摘要

摘要: 目的:应用Meta分析探讨基质金属蛋白酶-1(MMP-1) 基因启动子区1607位点单核苷酸多态性(SNP)与头颈癌(HNC)的易感相关性。方法:在中英文数据库中检索MMP-1与HNC相关性研究的文献,根据纳入与排除标准筛选文献,获取截止2014年1月以前公开发表的亚洲人群病例对照研究资料,应用Stata 10.0软件对研究结果进行异质性检验和效应值合并,并进行敏感性分析和偏倚评估。结果:9篇文献纳入研究,累计病例2049例,对照2158例;基于随机效应模型的Meta分析显示,MMP-1(-1607)1G/2G多态性与HNC相关性中基因型1G2G+2G2G vs. 1G1G (OR=1.45, 95% CI为 1.25~1.68, P<0.01),2G2G vs. 1G1G+1G2G (OR=1.77, 95% CI为 1.37~2.30, P<0.01),2G等位基因vs. 1G (OR=1.52, 95% CI为1.26~1.85, P<0.01),2G2G vs. 1G1G (OR=2.06, 95%CI为1.41~3.01, P<0.01)。结论:MMP-1 (-1607) 1G/2G多态性与HNC易感性存在关联,2G2G基因型携带者为HNC的易感人群。
- 基质金属蛋白酶-1 /
- 基因 /
- 头颈肿瘤
Abstract: Objective:To analyze and explore the association between the 1607(1G/2G) single nucleotide polymorphism (SNP) in promoter of matrix metalloproteinase-1 (MMP-1) gene and susceptibility of head and neck cancer (HNC) by Meta-analysis. Method:By the end of January 2014, the published literatures were collected for the case-control studies evaluating the relationship between HNC and -1607 SNP of MMP-1 gene from English and Chinese literature databases according to the inclusion and exclusion criteria. Then the meta-analysis, the heterogeneity, bias and sensitivity of the results of the eligible literatures were conducted by Stata 10.0. Result:A total of 9 studies including 2049 patients with HNC and 2158 controls were extracted for systematic review on the association of MMP-1(-1607)1G/2G SNP with the risk of HNC. Meta-analysis which based on random effects model showed that MMP-1(-1607)1G/2G SNP can significantly increase the risk of HNC[1G2G+2G2G vs. 1G1G:OR=1.45, 95% CI 1.25-1.68, P<0.01;2G2G vs. 1G1G+1G2G:OR=1.77, 95% CI 1.37-2.30, P<0.01; 2G vs. 1G:OR=1.52, 95% CI 1.26-1.85, P<0.01;2G2G vs. 1G1G:OR=2.06, 95%CI 1.41-3.01, P<0.01).Conclusion:MMP-1 (-1607) 1G/2G SNP has close relationship with HNC susceptibility, people who with 2G2G genotype carriers are susceptible to HNC.
- matrix metalloproteinase-1 /
- gene /
- head and neck carcinoma

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参考文献(23)

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