重度OSAHS患者治疗前后血清S100β蛋白与NSE的变化及意义

冯晓辉; 康晓明; 周芳; 肖旭平; 王继华

doi:10.13201/j.issn.1001-1781.2014.21.010

重度OSAHS患者治疗前后血清S100β蛋白与NSE的变化及意义

- 1 湖南师范大学第一附属医院(湖南省人民医院)耳鼻咽喉头颈外科(长沙, 410005);
- 2 长沙市中心医院耳鼻咽喉头颈外科

详细信息

通讯作者: 康晓明,E-mail:654352873@qq.com

中图分类号: R563.8

收稿日期: 2014-07-06

Serum S100β protein and NSE levels and significance of changes after treatment in patients with severe OSAHS

- 1 Department of Otolaryngology-Head and Neck Surgery, Hunan Provincial People's Hospital, the First Hospital of Hunan Normal University, Changsha, 410005, China;
- 2 Department of Otolaryngology-Head and Neck Surgery, the Central Hospital of Changsha

More Information

Corresponding author: KANG Xiaoming, E-mail: 654352873@qq.com

Received Date: 06 July 2014

摘要

摘要: 目的:了解重度OSAHS患者治疗前后血清S100β蛋白、NSE的水平及认知功能的变化,探讨重度OSAHS患者认知功能减退的分子机制。方法:选择100例经多导睡眠监测诊断为重度OSAHS的患者,于入院后第1天、CPAP治疗7 d后、综合治疗3个月后随访测定其血清S100β蛋白及NSE水平,同时进行蒙特利尔认知量表(MoCA)评分。结果:①S100β蛋白、NSE水平与AHI呈正相关,与最低血氧饱和度(LSaO₂)和MoCA评分呈负相关;②MoCA评分与AHI呈显著负相关,与LSaO₂呈显著正相关;③血清S100β蛋白、NSE水平在CPAP治疗7 d后有下降,与入院后第1天比较差异有统计学意义(P<0.05);综合治疗3个月后随访,血清S100β蛋白、NSE水平明显下降,与入院后第1天和CPAP治疗7 d后比较差异有统计学意义(P<0.05);④ CPAP治疗7 d后MoCA评分略有提高,与入院后第1天比较差异无统计学意义(P>0.05);综合治疗3个月后随访,MoCA评分显著提高,与入院后第1天和CPAP治疗7 d后比较差异有统计学意义(P<0.05)。结论:综合治疗可以降低血清S100β蛋白、NSE水平,提高MoCA评分。血清S100β蛋白、NSE水平和MoCA评分与OSAHS患者病情严重程度有一定的相关性。长期低氧血症和睡眠结构紊乱可能是导致血清S100β蛋白、NSE水平升高和认知功能障碍的原因之一,综合治疗能改善患者低氧血症,纠正睡眠结构紊乱,提高其认知功能进而提高生活质量。
- 睡眠呼吸暂停低通气综合征 /
- 阻塞性 /
- S100β蛋白 /
- NSE /
- 认知功能 /
- 持续正压通气 /
- 手术
Abstract: Objective:Understand the changes before and after treatment in patients with severe OSAHS serum S100β protein, NSE levels and cognitive function. To investigate the molecular mechanisms of cognitive dysfunction in patients with severe OSAHS. Serum S100β protein,NSE levels and cognitive function were examined before and after the therapy.Method:Select one hundred patients diagnosed as severe OSAHS were included,by polysomnography (PSG) diagnosis of severe OSAHS patients. Determination of serum S100β protein, and NSE levels and theat the same time be MoCA score were checked at after the day after admission, CPAP treatment for the 7th days after CPAP treatment and the 90th day after, comprehensive treatment in these patients for 3 months. Assessment of severe OSAHS patients with serum S100β protein, NSE basic level and MoCA score situation. Comparison of three groups serum S100β protein, NSE levels and MoCA score changes. Serum S100β protein, NSE detection assay (ELISA) method using enzyme-linked immunosorbent.Result:①Severe OSAHS patients with serum S100β protein, and NSE levels in severe OSAHS patients were positively correlated with AHI, but negatively correlated with lowest oxygen saturation (LSaO₂);②MoCA score in patients with severe OSAHS was significantly negatively correlated with AHI,but positively correlated with LSaO₂;③ S100β protein, NSE levels were negatively correlated with MoCA score;④Compared with admission, serum S100β protein, and NSE levels in these patients have declined after 7 days CPAP therapy, compared with admission the difference was statistically significant (P<0.05). After 3 months of comprehensive treatment,patients'serum S100β protein and,NSE levels were significantly decreased, compared with the admission and the 7th days after CPAP treatment. The difference was statistically significant(P<0.05).⑤After CPAP treatment for 7 days, the MoCA scores were slightly higher,but have there was no statistically significant difference compared with the admission(P>0.05). After 3 months of comprehensive treatment, MoCA score improved significantly,compared with the admission and 7 days after CPAP treatment the difference was statistically significant(P<0.05).Conclusion:Comprehensive treatment can reduce serum S100β protein, and NSE levels, and improve MoCA score. Disease severity in patients with OSAHS have a correlation some relative with the serum S100β protein, NSE levels and MoCA score. Long-term hypoxemia and the structure of sleep disorders may be the cause of elevated serum S100β protein,NSE levels elevated and causes of cognitive dysfunction. Comprehensive treatment can improve patient hypoxemia,correct disorders of sleep structure,and can improve cognitive function and to improve the quality of life of patients.
- sleep apnea hypopnea syndrome /
- obstructive /
- S100β protein /
- NSE /
- cognitive function /
- continuous positive airway pressure /
- surgery

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