Th17/Treg细胞失衡在嗜酸粒细胞性慢性鼻-鼻窦炎伴鼻息肉黏膜重塑中的作用

武大伟; 宋倩; 王建亭

doi:10.13201/j.issn.1001-1781.2014.20.029

Th17/Treg细胞失衡在嗜酸粒细胞性慢性鼻-鼻窦炎伴鼻息肉黏膜重塑中的作用

- 首都医科大学附属北京朝阳医院耳鼻咽喉头颈外科(北京, 100020)
基金项目:
北京市教育委员会科技计划面上项目(No:KM201210025027)

详细信息

通讯作者: 王建亭,E-mail:tingjw@126.com

中图分类号: R765.4

收稿日期: 2014-06-17

Study on the function and mechanism of Th17/Treg imbalance on mucosal remodeling of ECRSwNP

More Information

Corresponding author: WANG Jianting, E-mail: tingjw@126.com

Received Date: 17 June 2014

摘要

- 鼻窦炎 /
- 鼻息肉 /
- 嗜酸粒细胞 /
- Th17/Treg细胞 /
- 免疫调节
Abstract: Chronic rhinosinusitis (CRS) can be controlled by a combination of conservative treatment and surgical procedures.However, there is one group of CRS endotypes, refractory CRS, such as eosinophilic chronic rhinosinusitis with nasal polyp (ECRSwNP), for which the current treatment strategies of anti-inflammatory and/or antibiotic therapy or surgical removal of the lesion to improve sinus drainage are less effective.This lack of treatment efficacy highlights the need for further fundamental and clinical research to improve or restore nasal mucosal function of CRS.The role of the immune response in the pathogenesis of mucosal remodeling, which is a key problem in refractory CRS, is of particular current interest.ECRSwNP characterized by Th17/Treg imbalance induced by IL-6has a different mucosal remodeling pattern.This review intends to illustrate the role of the imbalance between Th17 (T helper 17) and Treg (regulatory T) cells in the mucosal remodeling of ECRSwNP and to suggest a novel therapeutic target on treating ECRSwNP.
- sinusitis /
- nasal polyps /
- eosinophils /
- Th17/Treg cells /
- immunoregulation

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