FAK和FGF-2在鼻咽癌中的表达及其临床意义

张娟; 李文光; 陈永平

doi:10.13201/j.issn.1001-1781.2014.12.020

FAK和FGF-2在鼻咽癌中的表达及其临床意义

- 1. 深圳市第五人民医院病理科(广东深圳, 518001);
- 2. 深圳市第五人民医院耳鼻咽喉科

详细信息

通讯作者: 张娟,E-mail:zjfour4@163.com

中图分类号: R739.63

收稿日期: 2013-10-28

Expression of FAK and FGF-2 in nasopharyngeal carcinoma and their clinical significance

- 1. Department of Pathology, the 5th People's Hospital of Shenzhen City, Shenzhen, 518001, China;
- 2. Department of Otorhinolaryngology, the 5th People's Hospital of Shenzhen City

More Information

Corresponding author: ZHANG Juan, E-mail: zjfour4@163.com

Received Date: 28 October 2013

摘要

摘要: 目的：研究黏着斑激酶（FAK）及成纤维细胞生长因子-2（FGF-2）在鼻咽癌中的表达及其临床意义。方法：应用免疫组织化学法检测鼻咽癌及鼻咽炎组织中FAK及FGF-2蛋白表达情况，并分析其与临床病理参数的关系。结果：在鼻咽癌组织中FAK、FGF-2蛋白阳性表达率与鼻咽炎组织中的表达率比较差异均有统计学意义（均P<0.05）；FAK、FGF-2蛋白的表达与淋巴结转移有关（分别P<0.01和P<0.05），与其他病理参数无关（P>0.05）；FAK的表达与FGF-2的表达呈正相关（r=0.350， P<0.01）。结论：FAK、FGF-2的高表达在鼻咽癌的发生、发展中具有一定的相关性。
- 鼻咽肿瘤 /
- 黏着斑激酶 /
- 成纤维细胞生长因子-2
Abstract: Objective: To explore the expressions of focal adhesion kinase (FAK) and the fibroblast growth factor-2(FGF-2) in nasopharyngeal carcinoma and their clinical significances. Method: The expressions of FAK protein and FGF-2 protein in nasopharyngeal carcinoma and nasopharyngitis were detected by immunohistochemical method, and their correlations with clinicopathological parameters were analyzed. Result: There were statistically significant differences in expression rates of FAK and FGF-2 protein between nasopharyngeal carcinoma group and nasopharyngitis group (P<0.05). The expression of FAK and FGF-2 protein were correlated with lymph node metastasis (P<0.01, P<0.05).There were no correlation between expression of FAK and FGF-2 protein and other pathological parameters (P>0.05). There was a positive correlation between FAK expression and FGF-2 expression (r=0.350, P<0.01). Conclusion: The high expressions of FAK and FGF-2 protein correlate with the oncogenesis and development of nasopharyngeal carcinoma.
- nasopharyngeal neoplasms /
- focal adhesion kinase /
- fibroblast growth factor-2

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