Necessity of central lymph node dissection in management of papillary thyroid microcarcinoma
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摘要: 目的:分析甲状腺微小乳头状癌发生中央区淋巴结转移的危险因素,探讨中央区淋巴结清扫的必要性。方法:回顾2004-01-2012-05期间手术治疗的85例甲状腺微小乳头状癌患者的临床资料,通过单因素及多因素分析,明确中央区淋巴结转移的危险因素,为选择性地进行中央区淋巴结清扫术提供依据。结果:85例患者均接受了中央区淋巴结清扫术,其中同侧中央区清扫者66例,双侧中央区清扫者19例。3例同期行颈部淋巴结清扫术。33例(38.8%)发生中央区淋巴结转移,3例(3.53%)发生颈侧区淋巴结转移。单因素分析显示:不同性别、年龄组中央区淋巴结转移差异无统计学意义(P>0.05);肿瘤直径大于5 mm、甲状腺外侵犯、多中心病灶、双侧病灶及术中探及中央区可疑阳性巴结者,发生中央区淋巴结转移的比例明显增高(P<0.05)。多因素分析显示:肿瘤直径大于5 mm(OR=3.862,P<0.05)、甲状腺外侵犯(OR=3.885,P<0.05)是发生中央区淋巴结转移的独立危险因素。结论:甲状腺微小乳头状癌患者肿瘤直径大5 mm和(或)甲状腺外侵犯时,发生中央区淋巴结转移的危险性增加,有必要行中央区淋巴结清扫术。Abstract: Objective:The objective of this study was to identify the risk factors for central lymph node metastasis(CLNM) of papillary thyroid microcarcinoma(PTMC) and to explore the necessity of central lymph node dissection(CLND).Method:Clinical data of 85 patients with PTMC, who had undergone surgical treatment between January 2004 and May 2012, were retrospected.Risk factors for CLNM were identified by univariate analysis and multivariate analysis,which can provide the basis for elective performance of CLND.Result:Of 85 patients,66 patients underwent ipsilateral CLND,while 19 patients received bilateral CLND.Concurrent cervical lymph node dissection was performed in 3 patients.The incidence of central and cervical lymph node metastasis was 38.8% and 3.53%,respectively. Univariate analysis showed that CLNM was correlated with tumor size >5 mm,extrathyroidal extension, multifocality, bilaterality and intraoperatively suspected lymph node,but not related to gender and age. Upon multivariate analysis, tumor size >5 mm(OR=3.862,P<0.05) and extrathyroidal extension(OR=3.885,P<0.05) were independent risk factors for CLNM.Conclusion:Patients presenting tumor size >5 mm and/or extrathyroidal extension may have an increased risk of central lymph node metastasis,and it is necessary to perform central lymph node dissection for them.
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[1] LIN J D.Increased incidence of papillary thyroid microcarcinoma with decreased tumor size of thyroid cancer[J].Med Oncol, 2010, 27:510-518.
[2] YU X M, WAN Y, SIPPEL R S, et al.Should all papillary thyroid microcarcinomas be aggressively treated?An analysis of 18, 445cases[J].Ann Surg, 2011, 254:653-660.
[3] ITO Y, MIYAUCHI A, INOUE H, et al.An observational trial for papillary thyroid microcarcinoma in Japanese patients[J].World J Surg, 2010, 34:28-35.
[4] KIM H Y, PARK W Y, LEE K E, et al.Comparative analysis of gene expression profiles of papillary thyroid microcarcinoma and papillary thyroid carcinoma[J].J Cancer Res Ther, 2010, 6:452-457.
[5] LIN J D.Increased incidence of papillary thyroid microcarcinoma with decreased tumor size of thyroid cancer[J].Med Oncol, 2010, 27:510-518.
[6] ROH J L, KIM J M, PARK C I.Central compartment reoperation for recurrent/persistent differentiated thyroid cancer:patterns of recurrence, morbidity, and prediction of postoperative hypocalcemia[J].Ann Surg Oncol, 2011, 18:1312-1318.
[7] 李潜, 王雁, 赵国强, 等.高频超声诊断甲状腺乳头状微小癌价值[J].中华实用诊断与治疗杂志, 2012, 26 (10):992-993.
[8] 姜双全, 姜丽丽, 王影, 等.常规超声及弹性成像诊断甲状腺微小癌的应用价值[J]中国医学影像技术, 2013, 29 (4):528-531.
[9] 张建明, 苏艳军, 刁畅, 等.甲状腺微小乳头状癌颈淋巴结清扫的临床研究[J].中国普外基础与临床杂志, 2011, 18 (4):414-418.
[10] HWANG H S, ORLOFF L A.Efficacy of preoperative neck ultrasound in the detection of cervical lymph node metastasis from thyroid cancer[J].Laryngoscope, 2011, 121:487-491.
[11] VASILEIADIS I, KARAKOSTAS E, CHARITOUDIS G, et al.Papillary thyroid microcarcinoma:clinicopathological characteristics and implications for treatment in 276patients[J].Eur J Clin Invest, 2012, 42:657-664.
[12] KIM B Y, JUNG C H, KIM J W, et al.Impact of clinicopathologic factors on subclinical central lymph node metastasis in papillary thyroid microcarcinoma[J].Yonsei Med J, 2012, 53:924-930.
[13] ZHANG L, WEI W J, JI Q H, et al.Risk factors for neck nodal metastasis in papillary thyroid microcarcinoma:a study of 1066patients[J].J Clin Endocrinol Metab, 2012, 97:1250-1257.
[14] ZHOU Y L, GAO E L, ZHANG W, et al.Factors predictive of papillary thyroid micro-carcinoma with bilateral involvement and central lymph node metastasis:a retrospective study[J].World J Surg Oncol, 2012, 10:67-67.
[15] LEE K J, CHO Y J, KIM S J, et al.Analysis of the clinicopathologic features of papillary thyroid microcarcinoma based on 7-mm tumor size[J].World J Surg, 2011, 35:318-323.
[16] CALISKAN M, PARK J H, JEONG J S, et al.Role of prophylactic ipsilateral central compartment lymph node dissection in papillary thyroid microcarcinoma[J].Endocr J, 2012, 59:305-311.
[17] KIM K E, KIM E K, YOON J H, et al.Preoperative prediction of central lymph node metastasis in thyroid papillary microcarcinoma using clinicopathologic and sonographic features[J].World J Surg, 2013, 37:385-391.
[18] YU X M, LLOYD R, CHEN H.Current treatment of papillary thyroid microcarcinoma[J].Adv Surg, 2012, 46:191-203.
[19] CIUFFREDA L, DE MARTINO D, BONFITTO N, et al.[Our experience on surgical treatment of papillary thyroid microcarcinoma] [J].G Chir, 2011, 32:41-44.
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