阻塞性睡眠呼吸暂停低通气综合征与左心室肥厚关系的探讨

龙朝庆; 邹华; 蔡谦; 郑亿庆

doi:10.13201/j.issn.1001-1781.2013.15.014

阻塞性睡眠呼吸暂停低通气综合征与左心室肥厚关系的探讨

- 1. 中山市小榄人民医院耳鼻咽喉科(广东中山, 528415);
- 2. 中山大学附属第二医院耳鼻咽喉头颈外科

详细信息

通讯作者: 邹华,E-mail:zouhua28@163.com

中图分类号: R766

收稿日期: 2012-11-19

Investigation of relationship between obstructive sleep apnea hypopnea syndrome and left ventricular hypertrophy

- 1. Department of Otolaryngology, Xiaolan People's Hospital, Zhongshan of Guangdong Province, 528415, China;
- 2. Department of Otolaryngology, Sun Yat-sen Memorial Hospital of Sun Yat-sen University, Guangzhou

More Information

Corresponding author: ZOU Hua, E-mail: zouhua28@163.com

Received Date: 19 November 2012

摘要

摘要: 目的:探讨阻塞性睡眠呼吸暂停低通气综合征（OSAHS）对左心室肥厚（LVH）的影响,OSAHS是否是LVH的独立危险因素。方法:选取原发性高血压（EH）或OSAHS的住院患者78例（研究组）及健康体检人员22例（对照组）。将研究组78例患者分为EH组26例、OSAHS组25例、EH+OSAHS组27例。对所有研究对象进行BMI、收缩压（SBP）及舒张压（DBP）,舒张末期室间隔厚度（IVSd）、舒张末期左室后壁厚度（LVPWd）等检测。根据资料和设计类型的不同,分别进行单因素方差分析及多元逐步回归分析。结果:对照组IVSd、LVP-Wd均低于研究组（EH组、OSAHS组及EH+OSAHS组）,而EH+OSAHS组的IVSd、LVPWd又分别高于EH组及OSAHS组（P＜0.05）;Stepwise逐步回归法回归分析结果显示AHI、SBP是影响IVSd、LVPWd的独立危险因素。结论:OSAHS及SBP是导致LVH的独立危险因素。
- 睡眠呼吸暂停低通气综合征,阻塞性 /
- 左心室肥厚 /
- 高血压
Abstract: Objective:The purpose of this study is to approach the impact of obstructive sleep apnea-hypopnea syndrome（OSAHS） on left ventricular hypertrophy（LVH）,to see whether OSAHS is an independent risk factor of LVH.Method:Chose patients with OSAHS or essential hypertension（EH） as the study group（78 cases） and subjects without OSAHS and EH as Normal control group（22 cases）.The study group was devided into 4 groups according to the diseases of OSAHS and EH:EH group（26 cases）,OSAHS group（25 cases） and EH+OSAHS group（27 cases）.Body mass index（BMI）,systolic blood pressure（SBP）,diastolic blood pressure（DBP）,interventricular septum thickness in diastole（IVSd）,left ventricular posterior wall thickness in diastole（LVPWd） etc were tested in all the subjects.Statistical analysis was carried out with software of SPSS 11.5 for windows.One-way analysis of variance and multiple stepwise regression analysis were used to assess the statistical evaluation.P<0.05 was considered statistically significant.Result:IVSd and LVPWd of the control group were lower than study groups（EH group,OSAHS group and EH+OSAHS group）,and IVSd,LVPWd of the EH+OSAHS group were higher than that of the EH group and OSAHS group（P<0.05）.Stepwise regression analysis showed that only AHI and SBP entered the regression equation（P<0.05）,it means that AHI and SBP are independent risk factors of IVSd and LVPWd.Conclusion:OSAHS and SBP are independent risk factors of LVH.
- sleep apnea hypopnea syndrome,obstructive /
- left ventricular hypertrophy /
- hypertension

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