标准桃金娘油胶囊预防鼻咽癌放疗后分泌性中耳炎的临床疗效观察

何剑; 吴平; 吴苏日娜; 米日喀米力·玉苏甫; 廖玲凤; 全华涛; 张帅; 唐瑶云

doi:10.13201/j.issn.1001-1781.2013.10.003

标准桃金娘油胶囊预防鼻咽癌放疗后分泌性中耳炎的临床疗效观察

- 1 中南大学湘雅医院耳鼻咽喉-头颈外科(长沙, 410008);
- 2 中南大学湘雅医院肿瘤科

详细信息

通讯作者: 唐瑶云,E-mail:shiw888@yahoo.com.cn

中图分类号: R739.63

收稿日期: 2012-05-27

Study on the preventive effect of the gelomyrtol forte from secretory otitis media in patients with nasopharyngeal carcinoma after radiotherapy

- 1 Department of Otorhinolaryngology-Head and Neck Surgery, Xiangya Hospital, Central South University, Changsha, 410008, China;
- 2 Department of Oncology, Xiangya Hospital, Central South University

More Information

Corresponding author: TANG Yaoyun, E-mail: shiw888@yahoo.com.cn

Received Date: 27 May 2012

摘要

摘要: 目的:观察标准桃金娘油胶囊预防鼻咽癌放疗后分泌性中耳炎的作用。方法:将60例放疗前无分泌性中耳炎的鼻咽癌患者分为2组(各30例):试验组和对照组。放疗开始后,试验组采用口服标准桃金娘油胶囊胶囊, 每次0.3 g,3次/d,7 d为1个疗程,口服药物3个月;对照组不做任何处理。放疗后3个月、6个月、1年随访,比较试验组和对照组症状、体征、纯音测听以及鼓室图变化是否有差别。结果:对照组发生分泌性中耳炎17 例(18耳)(56.67 %,17／30);试验组发生分泌性中耳炎7 例(7耳)(23.33%,7／30),2组比较差异有统计学意义(P＜0.01)。对照组17例(17耳)、试验组7例(7耳)出现耳鸣; 对照组20例(20耳)、试验组9例(9耳)出现耳闷塞感, 2组比较差异有统计学意义(P＜0.01)。放疗前试验组气导听阈均值为(7.5±2.0)dB HL,对照组为(8.3±4.0)dB HL,2组比较差异无统计学意义(P＞0.05),放疗结束后3个月,试验组气导听阈均值为(25.6±3.0)dB HL,与对照组[(40.7±5.0)dB HL]相比,差异有统计学意义(P＜0.01)。结论:鼻咽癌患者放疗前口服标准桃金娘油胶囊胶囊能有效降低放疗后分泌性中耳炎的发生率,能预防放疗后分泌性中耳炎的发生。
- 标准桃金娘油胶囊 /
- 鼻咽癌 /
- 分泌性中耳炎
Abstract: Objective: To observed the prevention efficacy of secretory otitis media after radiation therapy by the Myrtol Standardized Enteric Coated Soft Capsules.Method: Sixty patients with nasopharyngeal carcinoma who Diagnosis without secretory otitis media before radiation therapy were divided into experimental group and control group, 30 cases in each group. After the start of radiation therapy,the experimental group patients oral the Myrtol Standardized Enteric Coated Soft Capsules, each 0.3g, 3 times a day, 7 days a course of treatment, oral the medication three months, the patients in the control group received no treatment. 3 months and 6 months after the end of radiation therapy, whether there is a difference comparison of experimental group and the control group in symptoms, signs, pure tone audiometry and tympanogram change.Result: Seventeen patients(18 ears) (56.67%, 17/30) in the control group were suffering from secretory otitis media, 7 patients(7 ears) (23.33%, 7/30) in the experimental group were suffering from secretory otitis media. The difference between the two groups was statistically significant(P<0.01). 17 patients(17 ears) in the control group and 7 patients(7 ears)in the experimental group were suffering from tinnitus. 20 patients(20 ears) in the control group and 9 patients (10 ears)in the experimental group have ear choking feeling. The difference between the two groups was statistically significant(P<0.01).The air conduction hearing threshold of the experimental group before radiation therapy is (7.5±2.0) dB HL and the air conduction hearing threshold of the control group patients is(8.3±4.0)dB HL. The difference between the two groups was not statistically significant(P>0.05).3 months after radiation therapy,the gas conductive hearing threshold of the experimental group is(25.6±3.0)dB HL,but the data in the control group is(40.7±5.0) dB HL, The difference between the two groups was statistically significant(P<0.01).Conclusion: Patients with nasopharyngeal carcinoma oral the the Myrtol Standardized Enteric Coated Soft Capsules before radiation therapy can effectively reduce the incidence of secretory otitis media after radiotherapy, it can prevent the occurrence of secretory otitis media.
- gelomyrtol forte /
- nasopharyngeal carcinoma /
- secretory otitis media

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参考文献(4)

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