69例鼻咽癌常规放疗与调强放疗的不良反应比较

钟海林; 陈国谋; 林丹平; 陈国岛

doi:10.13201/j.issn.1001-1781.2013.09.006

69例鼻咽癌常规放疗与调强放疗的不良反应比较

- 解放军第422医院耳鼻咽喉头颈外科(广东湛江, 524005)

详细信息

通讯作者: 钟海林,E-mail:164622791@qq.com

中图分类号: R739.6

收稿日期: 2012-08-24

Comparison of side effects of intensity modulated radiotherapy and conventional radiotherapy in 69 cases with nasopharyngeal carcinoma

- Department of Otolaryngology-Head and Neck Surgery, the 422 Hospital of PLA, Zhanjiang, 524005, China

More Information

Corresponding author: ZHONG Hailin, E-mail: 164622791@qq.com

Received Date: 24 August 2012

摘要

摘要: 目的:比较鼻咽癌常规放疗和调强放疗的不良反应。方法:随机选择69例不同分期鼻咽癌患者,调强放疗组32例,常规放疗组37例。调强放疗组靶区为鼻咽肿瘤、咽旁间隙和颈部淋巴区,分次剂量为2.00~2.12 Gy/次,33~35次;常规放疗组用面颈联合野照射DT 40~60 Gy/(20~30次),耳前野补量至鼻咽区DT 70 Gy,颈部预防总量为DT 50~55 Gy。结果:调强放疗组和常规放疗组口干发生率分别为9.38%(3/32)和94.59%(35/37),张口困难发生率分别为6.25%(2/32)和72.97%(27/37),2组比较均差异有统计学意义(均P<0.01)。结论:鼻咽癌调强放疗与常规放疗相比较,在提高肿瘤局部控制率的同时明显降低了不良反应的发生,在患者经济条件允许的情况下应首选调强放疗。
- 鼻咽癌 /
- 放射治疗 /
- 不良反应 /
- 调强放射治疗
Abstract: Objective: To compare the side effects of intensity modulated radiotherapy(IMRT) and conventional radiotherapy in nasopharyngeal carcinoma.Method: Sixty nine cases of nasopharyngeal carcinoma were random selected by stages,with 32 cases in IMRT group and 37 cases in conventional radiotherapy group. The target areas in IMRT group were nasopharyngeal carcinoma, parapharyngeal space and neck lymphatic area with the fractional dose of 2.00-2.12 Gy per time, for 33-35 times. The cases in conventional radiotherapy group were given faciocervical field radiation, DT 40-60 Gy per time, for 20-30 times. The reinforcing dosage in lateral facial field increased to DT 70 Gy in the nasopharyngeal area. The prophylactic irradiation dose of the neck was DT 50-55 Gy.Result: The incidence of dry mouth one year after radiotherapy in the IMRT and conventional radiotherapy groups were 9.38%(3/32) and 94.59%(35/37) respectively, with a significant difference between the two groups(P<0.01). The incidence of difficulty in opening mouth in the IMRT and conventional radiotherapy groups were 6.25%(2/32) and 72.97%(27/37) respectively, with a significant difference between the two groups(P<0.01).Conclusion: Compared with the conventional radiotherapy, IMRT may improve the control rate and obviously decreases the side effects, It chould be recommended for the radiotherapy of nasopharyngeal carcinoma.
- nasopharyngeal carcinoma /
- radiotherapy /
- untoward effect /
- intensity modulated radiotherapy

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