鼻及喉部神经内分泌癌临床分析

古庆家; 李静娴; 冯勇; 樊建刚; 何刚; 朱鸿; 周水洪; 汪审清

doi:10.13201/j.issn.1001-1781.2013.09.004

鼻及喉部神经内分泌癌临床分析

- 1 四川省人民医院耳鼻咽喉头颈外科(成都, 610072);
- 2 四川省人民医院病理科;
- 3 浙江大学医学院附属第一医院耳鼻咽喉科

详细信息

通讯作者: 何刚,E-mail:heganghegang@live.cn

中图分类号: R739.6

收稿日期: 2012-01-09

Clinical analysis of nasal and laryngeal neuroendocrine carcinoma

- 1 Department of Otolaryngology-Head and Neck Surgery, Sichuan Provincial People's Hospital, Chengdu, 610072, China;
- 2 Department of Pathology, Sichuan Provincial People's Hospital;
- 3 Department of Otolaryngology, the First Affiliated Hospital, College of Medicine, Zhejiang University

More Information

Corresponding author: HE Gang, E-mail: heganghegang@live.cn

Received Date: 09 January 2012

摘要

摘要: 目的:探讨鼻、喉部神经内分泌癌的临床病理特点、治疗方法及疗效。方法:回顾性分析6例鼻、喉部神经内分泌癌患者的临床资料。采用单纯放疗1例,以手术为主的综合治疗5例。结果:全部患者随访11~84个月;2例术后复发,2例术后出现颈淋巴结转移,其中1例行颈淋巴结清扫术,1例无手术指征而行放、化疗。3例出现局部复发、颈部淋巴结肿大、肝或肺转移。至末次随访,4例死亡,2例无瘤生存。结论:鼻、喉部神经内分泌癌是一组形态、预后各异的病变,正确诊断有赖于临床特点、电镜、免疫组织化学检查结果。CT及MRI检查有助了解病变的范围及性质。不同病理类型神经内分泌癌的治疗方法及预后不同,宜采用以手术为主的综合治疗。
- 鼻 /
- 喉 /
- 神经内分泌肿瘤
Abstract: Objective: To investigate the clinopathological features,therapeutic methods and therapeutic effects of neuroendocrine carcinoma in nasal and laryngeal region.Method: Six cases with neuroendocrine carcinoma of the nose and the larynx were analyzed retrospectively. All cases were proved by pathology and immmunohistochemistry.One case was treated by only radiotherapy,and five cases by combined treatment(surgery followed by radiotherapy and chemotherapy).Result: All the patients were followed up for a period of 11-84 months. Two cases showed recurrence after operation.Three cases occurred cervical lymph node metastasis,of which 2 cases received neck dissection and 1 case received chemotherapy and radiotherapy due to no surgical indications.Three cases occured local recurrence, cervical lymphadenopathy, liver or lung metastases. Until the last follow up,four patients died of tumor,while two patients lived with no evidence of disease.Conclusion: Nasal and laryngeal neuroendocrine carcinoma is composed of a group of different morphology and prognosis lesions.Corrent diagnosis depends on clinical characteristic,electron microscopic and immunohistochemical examination.CT and MRI examination could be helpful to understand the extent of disease and lesion nature. The prognosis and treatment method of neuroendocrine carcinoma were vary with different pathological types. Combined treatment based on surgery should be adopted to the disease.
- nose /
- larynx /
- neuroendocrine carcinoma

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