云南地区1893例变应性鼻炎患者吸入性变应原谱分析

李斯斯; 余咏梅; 阮标; 刘奔; 赵筱扬; 邱吉蔚

doi:10.13201/j.issn.1001-1781.2013.05.022

云南地区1893例变应性鼻炎患者吸入性变应原谱分析

- 1 昆明医科大学2010级硕士研究生(昆明, 650032);
- 2 昆明医科大学附属第一医院耳鼻咽喉科

详细信息

通讯作者: 余咏梅; 阮标

中图分类号: R765.21

收稿日期: 2012-11-01

Prevalence of sensitization to aeroallergens in 1893 patients with allergic rhinitis in Yunnan

- 1 The 2010 Graduate Student of Kunming Medical University, Kunming, 650032, China;
- 2 Department of Otorhinolaryngology, the First Affiliated Hospital of Kunming Medical University

More Information

Corresponding authors: YU Yongmei ; RUAN Biao

Received Date: 01 November 2012

摘要

摘要: 目的: 调查云南地区变应性鼻炎(AR)患者吸入性变应原谱分布情况。方法: 回顾性分析1 893例确诊为AR的患者的皮内试验结果,按照年龄分为4个组:4~17岁组(605例),>17~35岁组(660例),>35~50岁组(507例),>50~70岁组(121例);按性别分为男性组(917例)和女性组(976例)。比较各组在变应原阳性率分布上的差异。结果: ①变应原皮内试验总阳性率为70.1%。阳性率前10位的变应原依次为:户尘螨、粉尘螨、室内尘土、夏秋季花粉、旱冬瓜、藜科、大籽蒿、禾本科、油菜、蟑螂;②变应原阳性个数中,以3重变应原阳性最多,其次为双重变应原阳性和单一变应原阳性;③阳性率前10位的变应原中,不同年龄组患者前3位阳性变应原均为户尘螨、粉尘螨和室内尘土。4~17岁组与其他3组变应原阳性率比较均差异有统计学意义(均P<0.01);④不同性别组患者间,除户尘螨、粉尘螨和室内尘土男性高于女性外(P<0.05),其余变应原阳性率均差异无统计学意义(均P>0.05)。结论: 云南地区AR患者的变应原主要是尘螨,其次为夏秋季花粉、旱冬瓜、藜科、大籽蒿、禾本科、油菜。各年龄段过敏原种类有所不同,变应原分布与性别无明显相关性。
- 鼻炎 /
- 变应性 /
- 变应原 /
- 皮内试验 /
- 流行病学
Abstract: Objective: To investigate which aeroallergens were prevalent in patients with allergic rhinitis in Yunnan.Method: Retrospective analysis of the medical records of intradermal test performed in 1893 AR patients. The samples were divided into four age groups:4-17-year-olds,>17-35-year-olds,>35-50-year-olds and >50-70-year-olds. According to gender,the samples were devided into two groups: the males and the females. The positive rate of aeroallergens were compared among the groups.Result: ①The total positive rate of intradermal test was 70.1%.The top ten allergens were as follow: dermatophagoides pteronyssinus,dermatophagoides farina,house dust,pollen of the summer and autumn, alnus nepalensis, chenopodiaceae,mugwort, poaceae,brassica and cockroach. ②In all groups,patients with triple positive allergens were the most common,followed by dual positive allergens and single positive allergen.③Among the top ten allergens,the top three positive ones in all groups were dermatophagoides pteronyssinus,dermatophagoides farina and house dust.And there were significant diferences between 4-17-year-olds group and the other age groups(P<0.01). ④There was no significant diference between male and female patients in distribution of aeroallergens except House dust and mite.Conclusion: The most common allergen in patients with allergic rhinitis in Yunnan is mite,the follow are pollen of the summer and autumn, alnus nepalensis, chenopodiaceae, mugwort, poaceae, and brassica. The distribution of aeroallergens are different among the age groups,but has no evident correlation with gender.
- rhinitis /
- allergic /
- allergens /
- intradermal tests /
- epidemiology

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参考文献(17)

[1]	BOUSQUET J,KHALTAEV N,CRUZ A A,et al.AllergicRhinitis and its Impact on Asthma(ARIA)2008 update(in collaboration with the World Health Organization,GA(2)LEN and AllerGen)[J].Allergy,2008,63 Suppl 86:8-160.
[2]	ASHER M J,MONTEFORT S,BJORKSTEN B,et al.Worldwide time trends in the prevalence of symptoms ofashma,allergic rhinoconjunctivitis,and eczema in child-hood:ISAAC phases one and three repeat multicountrycross-sectional surveys[J].Lancet,2006,368:733-743.
[3]	BOUSQUET P J,CHINN S,JANSON C,et al.Geograph-ical varation in the prevalence of positive skin tests to en-vironmental aeroallergens in the European CommunityRespiratory Health SurveyⅠ[J].Allergy,2007,62:301-309.
[4]	叶世泰.变态反应学[M].北京:科学卫生出版社,1998:110-113.
[5]	江满杰,李泽卿,程友,等.变应性鼻炎标准化皮肤试验结果分析[J].临床耳鼻咽喉头颈外科杂志,2009,23(17):800-801.
[6]	王成硕,张罗,韩德民,等.北京地区变应性鼻炎患者吸入变应原谱分析[J].临床耳鼻咽喉科杂志,2006,20(5):204-207.
[7]	杨酉,赵岩,王成硕,等.变应性鼻炎患者10030例吸入性变应原谱分析[J].中华耳鼻咽喉头颈外科杂志,2011,46(11):914-920.
[8]	黄雪琨,陈玉莲,张革化,等.广州地区1376例变应性鼻炎常见吸入性变应原分析[J].中国耳鼻咽喉头颈外科,2011,18(7):374-377.
[9]	黄芳,赵艳,何荆培,等.荆门地区变应性鼻炎患者吸入变应原谱分析[J].临床耳鼻咽喉头颈外科杂志,2010,24(8):341-343.
[10]	VALOVIRTA E,MYRSETH S E,PALKONEN S.Thevoice of the patients:allergic rhinitis is not a trivial dis-ease[J].Curr Opinion Allergy Immunol,2008,8:1-9.
[11]	BOUSQUET J,VAN CAUWENBERGE P,KHAL-TAEV N,et al.Aria Workshop Group,World Health Or-ganization.Allergic rhinitis and its impact on asthma[J].J Allergy Clin Immunol,2001,108:147-334.
[12]	桂晓钟,程静,赵军,等.413例变应性鼻炎变应原皮肤点刺测试结果分析[J].临床耳鼻咽喉头颈外科杂志,2009,23(23):1096-1097.
[13]	杨庆贵.尘螨变应原的分子生物学研究进展[J].中国寄生虫与寄生虫病杂志,2005,23(6):467-469.
[14]	宋薇薇,林小平,仲欢欢,等.辽宁地区变应性鼻炎患者吸入变应原谱分析[J].中华临床免疫和变态反应杂志,2011,5(4):263-267.
[15]	武维,亚力坤.亚生,陈悦,等.新疆昌吉地区1564例变应性鼻炎患者变应原分布分析[J].临床耳鼻咽喉头颈外科杂志,2011,25(17):789-790.
[16]	潘黎明,蒋学范,潘立勇,等.杭州地区变应性鼻炎及变应性哮喘患者的血清变应原测定[J].临床耳鼻咽喉头颈外科杂志,2009,23(2):77-79.
[17]	陈建军,孔维佳,项济生,等.湖北地区变应性鼻炎变应原年龄特征分析[J].临床耳鼻咽喉头颈外科杂志,2008,22(13):683-685.