原发性鼻腔透明细胞癌1例并文献复习

洪娟; 毕涌; 李鹏; 方练

doi:10.13201/j.issn.1001-1781.2013.05.009

原发性鼻腔透明细胞癌1例并文献复习

- 1 温州医学院附属第一医院耳鼻咽喉科(浙江温州, 325000);
- 2 温州医学院附属第一医院神经内科;
- 3 温州医学院附属第一医院病理科

详细信息

通讯作者: 洪娟,E-mail:blesshj3@yahoo.com.cn

中图分类号: R739.6

收稿日期: 2012-10-21

Primary nasal clear cell carcinoma:a case report and literature review

- 1 Department of Otolaryngology, the First Affiliated Hospital of Wenzhou Medical College, Wenzhou, 325000, China;
- 2 Department of Neurology, the First Affiliated Hospital of Wenzhou Medical College;
- 3 Department of Pathology, the First Affiliated Hospital of Wenzhou Medical College

More Information

Corresponding author: HONG Juan, E-mail: blesshj3@yahoo.com.cn

Received Date: 21 October 2012

摘要

摘要: 目的: 探讨原发性鼻腔透明细胞癌的临床表现及病理特点,总结其诊断及治疗方法。方法: 分析1例原发性鼻腔透明细胞癌患者的临床资料,复习1992 年以来11例相关文献,做出总结报道。结果: 12例原发性鼻腔-鼻窦透明细胞癌中8例(66.7%)主要表现为鼻出血,4例(33.3%)出现骨质破坏;CT显示鼻腔、鼻窦内条片状类似软组织密度影,行单纯手术切除治疗3例(25.0%),手术切除联合放、化疗7例(58.3%),单纯放化疗2例(16.7%)。治疗后随访6个月~10年,仅1例患者因出现肺部转移死亡,余均健在。结论: 原发性鼻腔-鼻窦透明细胞癌较罕见,早期症状以鼻出血多见,病理学上需与转移性透明细胞癌及多种含透明细胞的涎腺肿瘤鉴别。治疗以手术切除联合放化疗为主,短期内预后较好。早期局限于鼻腔和鼻窦的有基底的肿瘤可考虑鼻内镜手术,术后建议每半年复查一次。
- 透明细胞癌 /
- 鼻窦 /
- 治疗
Abstract: Objective: To explore the clinical and pathological characteristics of the primary nasal-sinonasal clear cell carcinoma, and then summarize the diagnosis and treatment.Method: The clinical, imaging and pathological data were analyzed in one patient with primary nasal-sinonasal clear cell carcinoma. The domestic and foreign related literatures from 1992 were reviewed and summarized.Result: In 12 cases of primary nasal-sinonasal clear cell carcinoma, 8 cases(66.7%)mainly presented with nasal bleeding,4 cases(33.3%) with destroyed bone. CT scan showed the sheet shadow similar to soft tissue density in the nasal cavity and paranasal sinuses.Three cases(25.0%)were only treated by surgical resection,7 cases(58.3%) were treated by surgical resection combined with radiotherapy and chemotherapy, 2 cases(16.7%) were treated by radiotherapy alone. During the 6 months to 10 years follow up, only one patient died of lung metastasis.Conclusion: Primary nasal-sinonasal clear cell carcinoma is rare.Nasal bleeding is commonly one of the early symptoms. It must be differentiated from metastatic clear cell carcinoma and a variety of salivary gland tumors with clear cell in pathology. Surgery combined with radiotherapy and chemotherapy is effective treatment. Short-term prognosis is good. Endoscopic surgery can be used to the tumor with a base limited in the nasal cavity and sinuses in early time. The regular check after surgery should be taken to the patients every half a year.
- clear cell carcinoma /
- sinonasal /
- therapy

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