Abstract: Objective: To study the feature and treatment method of patients with empty sella merger cerebrospinal fluid leakage of nasal.Method: There were 8 cases with empty sella merger cerebrospinal fluid leakage of nasal,2 cases were accepted the repairing surgery of cerebrospinal fluid leakage one time, 4 cases were accepted the repairing surgery of cerebrospinal fluid leakage used endoscope 2 times, 1 case was accepted repairing surgery of cerebrospinal fluid leakage used endoscope merge craniotomy and ventricle celiac bypass,1 case recurrenced after repairing surgery of cerebrospinal fluid was recured after conservative treatment. Some postoperative were stayed in bed for three weeks and lumbar drainage for 1 week.Result: One case of cerebral hemorrhage after surgery was cured with craniotomy, followed for 2 years without recurrence.One case was recured after conservative treatment. Two cases recurrenced after surgery 3 years ago were accepted surgery again followed by one year without recurrence. One case who recurrence 1 year later was accepted repairing surgery of cerebrospinal fluid leakage used endoscope merge craniotomy and ventricle celiac bypass followed six months without recurrence. One case after once surgery was followed half a year without recurrence. One case with recurrene 5 years later was accepted repairing surgery again.Conclusion: The patient with empty sella combined cerebrospinal fluid leakage of nasal was rare, the main methed was endoscopic sinus surgery treatment, but it recurred usually. The patients with repeatedly recurrene can be considered to accepted the surgery of ventricle celiac bypass. It required long-term postoperative follow-up and review.