阻塞性睡眠呼吸暂停低通气综合征对心血管疾病的影响

陈曦; 李进让; 孙建军

doi:10.13201/j.issn.1001-1781.2012.16.013

阻塞性睡眠呼吸暂停低通气综合征对心血管疾病的影响

- 海军总医院耳鼻咽喉头颈外科(北京, 100048)

详细信息

通讯作者: 孙建军,E-mail:jjsun85@sina.com.cn

中图分类号: R563.8

收稿日期: 2011-09-02

Roles of cardiovascular disease in obstructive sleep apnea hypopnea syndrome

- Department of Otolaryngology Head and Neck Surgery, Navy General Hospital, Beijing, 100048, China

More Information

Corresponding author: SUN Jianjun, E-mail: jjsun85@sina.com.cn

Received Date: 02 September 2011

摘要

摘要: 目的:探讨阻塞性睡眠呼吸暂停低通气综合征(OSAHS)与心血管疾病危险因素的相关性。方法:选取行睡眠监测确诊为OSAHS并准备手术的患者228例,分别测定血常规(红细胞压积,血红蛋白,红细胞)和血液生化指标(高密度脂蛋白,低密度脂蛋白,总胆固醇,甘油三脂,肌酐,尿素氮),并分析与呼吸暂停低通气指数(AHI)、呼吸暂停指数(AI)、低通气指数、最低血氧饱和度的相关性。将228例患者分为3组:轻度组(5≤AHI＜15)、中度组(15≤AHI＜30)和重度组(30≤AHI),分别统计各组发病率,并行ROC分析评估AHI、AI诊断OSAHS伴心血管疾病危险因素的价值。结果:①轻度组和中度组并发心血管疾病危险因素的发病率无明显差异(χ²=0.428,P＞0.05),而重度组发病率明显大于轻度组和中度组(χ²=12.89,P＜0.05)。ROC分析示AHI、AI的ROC曲线下面积分别为0.678、0.679,有一定诊断价值。②血常规与AHI有一定的正相关性(r=0.176~0.194,P＜0.05)。结论:OSAHS可能是导致心血管疾病的病因之一。
- 睡眠呼吸暂停低通气综合征,阻塞性 /
- 心血管疾病 /
- 危险因素
Abstract: Objective: To explore the roles of cardiovascular disease in obstructive sleep apnea hypopnea syndrome.Method: All 228 OSAHS patients underwent the examination of biochemical and complete blood count. The correlation analysis between AHI,AI,HI,LSaO₂, complete blood count,and biochemical examination were employed.Two hundred and twenty-eight cases were divided into 3 groups according to sleep apnea hypopnea index(AHI):group 1(5≤AHI<15),group 2(15≤AHI<30),group 3(30≤AHI). Morbidity of diseases in each group was calculated and the value of AHI and AI for morbidity was analyzed by using ROC curve.Result: ①No statistically significant difference was found between group 1 and group 2(χ²=0.428,P＞0.05 ).There was significant difference between group 3 and group1,2(χ²=12.89,P＜0.05).The areas under the ROC curves of AHI and AI were 0.678 and 0.679,repectively. ②There was significant positive correlation between AHI and complete blood count parameters(r=0.176 to 0.194,P＜0.05).Conclusion: OSAHS may be one of the predisposing factors of cardiovascular disease.
- sleep apnea-hypopnea syndrome, obstructive /
- cardiovascular diseases /
- risk factors

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