双侧耳蜗切除术致听力剥夺大鼠的听性脑干反应改变

韩海霞; 徐鸥; 黄河银; 王玉杏; 路虹

doi:10.13201/j.issn.1001-1781.2014.07.010

双侧耳蜗切除术致听力剥夺大鼠的听性脑干反应改变

- 1 河北医科大学第二医院耳鼻咽喉科(石家庄, 050000);
- 2 四川省中西医结合医院耳鼻咽喉科
基金项目:
河北省自然科学基金资助项目 (No:C2011206036)

河北省卫生厅医学科学研究重点课题计划资助项目 (No:20110375)

详细信息

通讯作者: 路虹, E-mail:wx_900804@163.com

中图分类号: R764.04

收稿日期: 2013-06-07

Change of auditory brainstem response in hearing deprivation rat model induced by bilateral cochlears ablation

- 1 Department of Otolaryngology, the Second Hospital of Hebei Medical University, Shijiazhuang, 050000, China;
- 2 Department of Otolaryngology, Sichuan Hospital of Integrated Chinese and Western Medicine, Chengdu

More Information

Corresponding author: LU Hong, E-mail: wx_900804@163.com

Received Date: 07 June 2013

摘要

摘要: 目的:通过比较大鼠在双侧耳蜗切除术后不同时间点听性脑干反应(ABR)的变化,探讨ABR在测试听力剥夺大鼠模型中的应用价值。方法:选取2周龄SD大鼠40只,随机分为实验组4组(2周组、4周组、6周组、8周组)和对照组4组,每组5只(10耳)。实验组动物在双侧耳蜗损毁术后不同时间点与其对照组行ABR检测,记录ABR阈值及各波潜伏期和波间期。结果:实验组ABR反应阈明显升高,与对照组相比,差异有统计学意义(P<0.01),各波潜伏期和波间期明显延长(P<0.01);实验2周组、4周组与6周组和8周组相比,ABR反应阈的差异也有统计学意义(P<0.01)。结论:双侧耳蜗切除术可导致大鼠ABR反应阈明显增高,各波潜伏期和波间期明显延长;听力剥夺效果从术后4周开始越发明显。
- 大鼠 /
- 听力剥夺 /
- 听性脑干反应
Abstract: Objective:To observe the change of auditory brainstem response (ABR) in hearing deprivation rat model induced by bilateral cochlears ablation at different time points. Method:Forty SD rats were randomly divided into four experiment groups including 2-week group, 4-week group, 6-week group, 8-week group and four control groups with 5 rats (n=10) in each group. Then bilateral cochlears ablation was applied to experiment groups. The threshold value of ABR was measured at different time and latentperiod of each wave was compared. Result:The threshold of ABR in experiment group was elevated significantly. The latentperiod of each wave was prolonged significantly (P<0.01). In experiment group, the threshold value of ABR in 2-week and 4-week group was significantly greater than that in 6-week group and 8-week group (P<0.01). Conclusion:Bilateral cochlears ablation surgery could elevate the threshold of ABR and latentperiod of each wave prolonged. The effect of hearing deprivation became apparent after surgery for 4 weeks.
- rat /
- hearing deprivation /
- auditory brainstem response

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