2型固有淋巴细胞在气道炎症中的研究进展

范大川; 王向东; 张罗

doi:10.13201/j.issn.1001-1781.2016.08.026

2型固有淋巴细胞在气道炎症中的研究进展

- 1. 首都医科大学附属北京同仁医院耳鼻咽喉头颈外科和变态反应科(北京, 100730);
- 2. 教育部耳鼻咽喉科重点实验室北京市耳鼻咽喉科研究所

详细信息

通讯作者: 张罗,E-mail:dr.luozhang@139.com

中图分类号: R562

收稿日期: 2016-01-17

A review on group 2 innate lymphoid cells in airway inflammation

More Information

Corresponding author: ZHANG Luo, E-mail: dr.luozhang@139.com

Received Date: 17 January 2016

摘要

- 2型固有淋巴细胞 /
- 气道炎症 /
- 过敏反应
Abstract: Inflammatory airway diseases, including allergic rhinitis and asthma, are type 2 immune responses induced by antigen presenting cells and T helper cells, resulting as a consequence of great recruitment of effect cells and release of cytokines. Group 2 innate lymphoid cells were originally described as a novel population of lineage-negative cells and play an important role in the onset and progression of airway inflammation by producing the critical Th2-type cytokines IL-5 and IL-13 in response to epithelial cell-derived IL-25,IL-33 and thymic stromal lymphopoietin. Along with a better understanding of regulatory and effect mechanism, targeting ILC2s could be a potential therapeutic approach in inflammatory airway diseases.
- group 2 innate lymphoid cell /
- airway inflammation /
- anaphylaxis

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参考文献(32)

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