糖皮质激素抵抗在耳鼻咽喉疾病中的研究进展

李亚秀; 佘万东

doi:10.13201/j.issn.2096-7993.2024.07.020

糖皮质激素抵抗在耳鼻咽喉疾病中的研究进展

李亚秀¹,
佘万东^1, ,

- 南京医科大学鼓楼临床医学院耳鼻咽喉头颈外科(南京，210008)
基金项目:
国家自然科学基金(No：81670931)；南京市医学重点科技发展项目(No：ZKX-21012)；江苏省自然科学基金(No：BK20231122)；南京鼓楼医院临床研究专项资金面上项目：(No：2022-LCYJ-NMS-01)

详细信息

通讯作者: 佘万东，E-mail：shewandong@163.com

中图分类号: R764.43

收稿日期: 2023-11-09

修回日期: 2024-04-16

刊出日期: 2024-07-03

Advances in glucocorticoid resistance in otorhinolaryngological diseases

LI Yaxiu¹,
SHE Wandong^1, ,

- Department of Otorhinolaryngology, Head and Neck Surgery, Nanjing Drum Tower Hospital Clinical College of Nanjing Medical University, Nanjing, 210008, China

More Information

Corresponding author: SHE Wandong, E-mail: shewandong@163.com

Received Date: 09 November 2023

Revised Date: 16 April 2024

Publish Date: 03 July 2024

摘要

摘要: 糖皮质激素(glucocorticoids，GC)临床上广泛应用于自身免疫性内耳病、突发性聋、梅尼埃病及鼻窦炎等耳鼻咽喉疾病的治疗，部分患者存在GC抵抗现象，但导致GC抵抗因素机制尚不清楚，本文从GC受体因素和非GC受体因素两方面阐述了GC抵抗的相关机制，并综述其在耳鼻咽喉科疾病的最新研究进展，旨在未来寻找GC抵抗生物标志物，提高GC疗效提出新策略。
- 糖皮质激素抵抗 /
- 糖皮质激素 /
- 糖皮质激素受体 /
- 突发性聋 /
- 鼻窦炎
Abstract: Glucocorticoids(GC) are widely used in the clinical treatment of autoimmune inner ear diseases, sudden sensorineural hearing loss, Meniere's disease, sinusitis and other otolaryngology diseases. However, GC resistance remains a major factor contributing to the poor efficacy of clinical treatments. The mechanism of GC resistance is still unclear. This paper reviews the related mechanisms of GC resistance from the perspectives of GC receptor factors and non-GC receptor factors. Additionally, it summarizes the latest research progress on GC resistance in otolaryngological diseases, with the aim of identifying effective clinical alternative treatment options for reversing GC resistance in the future.
- glucocorticoid resistance /
- glucocorticoids /
- receptor /
- sudden sensorineural hearing loss /
- sinusitis

HTML全文

参考文献(41)

[1]	Fokkens WJ, Lund VJ, Hopkins C, et al. European position paper on rhinosinusitis and nasal polyps 2020[J]. Rhinology, 2020, 58(Suppl S29): 1-464.
[2]	Chen K, Yu ZJ, Yang J, et al. Expression of cysteinyl leukotriene receptor GPR17 in eosinophilic and non-eosinophilic chronic rhinosinusitis with nasal polyps[J]. Asian Pac J Allergy Immunol, 2018, 36(2): 93-100.
[3]	Bayar Muluk N, Cingi C, Scadding GK, et al. Chronic rhinosinusitis-could phenotyping or endotyping aid therapy?[J]. Am J Rhinol Allergy, 2019, 33(1): 83-93. doi: 10.1177/1945892418807590
[4]	Nakagawa T, Kumakawa K, Usami S, et al. A randomized controlled clinical trial of topical insulin-like growth factor-1 therapy for sudden deafness refractory to systemic corticosteroid treatment[J]. BMC Med, 2014, 12: 219. doi: 10.1186/s12916-014-0219-x
[5]	Lo CY, Wang CH, Wang CW, et al. Increased interleukin-17 and glucocorticoid receptor-β expression in interstitial lung diseases and corticosteroid insensitivity[J]. Front Immunol, 2022, 13: 905727. doi: 10.3389/fimmu.2022.905727
[6]	Tang BL, Han J, Wang F, et al. GR-α and GR-β mRNA levels in peripheral blood mononuclear cells of acute myelitis patients can assist in the identification of glucocorticoid sensitivity and are correlated with glucocorticoid therapeutic effect[J]. Ann Hum Genet, 2022, 86(5): 268-277. doi: 10.1111/ahg.12472
[7]	Liang Y, Song MM, Liu SY, et al. Relationship between expression of glucocorticoid receptor isoforms and glucocorticoid resistance in immune thrombocytopenia[J]. Hematology, 2016, 21(7): 440-446. doi: 10.1080/10245332.2015.1102371
[8]	Sun XL, Fang MY, Guan YC, et al. Changes of glucocorticoid receptor isoforms expression in acute lymphoblastic leukemia correlate with glucocorticoid resistance[J]. Pharmazie, 2015, 70(5): 316-321.
[9]	Zhang XL, Chen JX, Gao ZW, et al. Response of glucocorticoid receptor alpha and histone deacetylase 2 to glucocorticoid treatment predicts the prognosis of sudden sensorineural hearing loss[J]. Clin Exp Otorhinolaryngol, 2019, 12(4): 367-375. doi: 10.21053/ceo.2018.01298
[10]	Chen XB, Zhang Q, Yang CP, et al. GRβ regulates glucocorticoid resistance in sudden sensorineural hearing loss[J]. Curr Pharm Biotechnol, 2021, 22(9): 1206-1215. doi: 10.2174/1389201021666201008163534
[11]	Xue JM, An YF, Suo LM, et al. Livin in synergy with Ras induces and sustains corticosteroid resistance in the airway mucosa[J]. Int J Biol Sci, 2021, 17(8): 2089-2098. doi: 10.7150/ijbs.58427
[12]	Nguyen QT, Kim D, Iamsawat S, et al. Cutting edge: steroid responsiveness in Foxp3⁺ regulatory T cells determines steroid sensitivity during allergic airway inflammation in mice[J]. J Immunol, 2021, 207(3): 765-770. doi: 10.4049/jimmunol.2100251
[13]	Jiang Y, Liu B, Bao X, et al. TNF-α regulates the glucocorticoid receptor alpha expression in human nasal epithelial cells via p65-NF-κb and p38-MAPK signaling pathways[J]. Iran J Biotechnol, 2023, 21(1): e3117.
[14]	Wang Z, Li P, Zhang Q, et al. Interleukin-1β regulates the expression of glucocorticoid receptor isoforms in nasal polyps in vitro via p38 MAPK and JNK signal transduction pathways[J]. J Inflamm(Lond), 2015, 12(1): 3. doi: 10.1186/s12950-014-0046-z
[15]	Li Y, Chang LH, Huang WQ, et al. IL-17A mediates pyroptosis via the ERK pathway and contributes to steroid resistance in CRSwNP[J]. J Allergy Clin Immunol, 2022, 150(2): 337-351. doi: 10.1016/j.jaci.2022.02.031
[16]	Fernández-Bertolín L, Mullol J, Fuentes-Prado M, et al. Effect of lipopolysaccharide on glucocorticoid receptor function in control nasal mucosa fibroblasts and in fibroblasts from patients with chronic rhinosinusitis with nasal polyps and asthma[J]. PLoS One, 2015, 10(5): e0125443. doi: 10.1371/journal.pone.0125443
[17]	Kobayashi Y, Kanda A, Yun Y, et al. Reduced local response to corticosteroids in eosinophilic chronic rhinosinusitis with asthma[J]. Biomolecules, 2020, 10(2): 326. doi: 10.3390/biom10020326
[18]	Xia L, Liu JJ, Sun YY, et al. Rosiglitazone improves glucocorticoid resistance in a sudden sensorineural hearing loss by promoting MAP kinase phosphatase-1 expression[J]. Mediators Inflamm, 2019, 2019: 7915730.
[19]	Qian L, Xu DH, Xue FS, et al. Interleukin-35 sensitizes monocytes from patients with asthma to glucocorticoid therapy by regulating p38 MAPK[J]. Exp Ther Med, 2020, 19(5): 3247-3258.
[20]	Monteiro LLS, Franco OL, Alencar SA, et al. Deciphering the structural basis for glucocorticoid resistance caused by missense mutations in the ligand binding domain of glucocorticoid receptor[J]. J Mol Graph Model, 2019, 92: 216-226. doi: 10.1016/j.jmgm.2019.07.020
[21]	Chien CY, Tai SY, Li KH, et al. Glucocorticoid receptor(NR3C1) genetic polymorphisms and the outcomes of sudden sensorineural hearing loss[J]. Le J D'oto Rhino Laryngol De Chir Cervico Faciale, 2023, 52(1): 13.
[22]	Wu C, Fang F, Zhan XJ, et al. The association between glucocorticoid receptor(NR3C1) gene polymorphism and difficult-to-treat rhinosinusitis[J]. Eur Arch Otorhinolaryngol, 2022, 279(8): 3981-3987. doi: 10.1007/s00405-021-07228-z
[23]	刘双喜, 车娜, 金玲, 等. 慢性鼻窦炎患者FCER2基因多态性与鼻用糖皮质激素疗效的相关性研究[J]. 临床耳鼻咽喉头颈外科杂志, 2023, 37(11): 856-863. doi: 10.13201/j.issn.2096-7993.2023.11.002
[24]	Liang X, Jin P, Zhan CC, et al. Glucocorticoid-induced transcript 1(GLCCI1) SNP rs37937 is associated with the risk of developing allergic rhinitis and the response to intranasal corticosteroids in a Chinese Han population[J]. Am J Rhinol Allergy, 2023, 37(6): 751-757. doi: 10.1177/19458924231193156
[25]	Hou J, She WD, Du XP, et al. Histone deacetylase 2 in sudden sensorineural hearing loss patients in response to intratympanic methylprednisolone perfusion[J]. Otolaryngol Head Neck Surg, 2016, 154(1): 164-170. doi: 10.1177/0194599815606911
[26]	Xie L, Zhou Q, Chen X, et al. Elucidation of the Hdac2/Sp1/miR-204-5p/Bcl-2 axis as a modulator of cochlear apoptosis via in vivo/in vitro models of acute hearing loss[J]. Mol Ther Nucleic Acids, 2021, 23: 1093-1109. doi: 10.1016/j.omtn.2021.01.017
[27]	Zhou QQ, Dai YH, Du XP, et al. Aminophylline restores glucocorticoid sensitivity in a guinea pig model of sudden sensorineural hearing loss induced by lipopolysaccharide[J]. Sci Rep, 2017, 7(1): 2736. doi: 10.1038/s41598-017-02956-x
[28]	Tao FL, Zhou YY, Wang MW, et al. Metformin alleviates chronic obstructive pulmonary disease and cigarette smoke extract-induced glucocorticoid resistance by activating the nuclear factor E2-related factor 2/heme oxygenase-1 signaling pathway[J]. Korean J Physiol Pharmacol, 2022, 26(2): 95-111. doi: 10.4196/kjpp.2022.26.2.95
[29]	Qi H, Gao ZW, Hou J, et al. Nuclear factor erythroid 2-related factor 2-histone deacetylase 2 pathway in the pathogenesis of refractory sudden sensorineural hearing loss and glucocorticoid resistance[J]. ORL J Otorhinolaryngol Relat Spec, 2021, 83(4): 227-233. doi: 10.1159/000515205
[30]	Zheng Y, Gao N, Zhang WX, et al. Melatonin alleviates the oxygen-glucose deprivation/reperfusion-induced pyroptosis of HEI-OC1 cells and cochlear hair cells via MT-1, 2/Nrf2(NFE2 L2)/ROS/NLRP3 pathway[J]. Mol Neurobiol, 2023, 60(2): 629-642. doi: 10.1007/s12035-022-03077-x
[31]	Yazdani N, Kakavand Hamidi A, Ghazavi H, et al. Association between macrophage migration inhibitory factor gene variation and response to glucocorticoid treatment in sudden sensorineural hearing loss[J]. Audiol Neurootol, 2015, 20(6): 376-382. doi: 10.1159/000438741
[32]	Zhu WY, Jin X, Ma YC, et al. Correlations of MIF polymorphism and serum levels of MIF with glucocorticoid sensitivity of sudden sensorineural hearing loss[J]. J Int Med Res, 2020, 48(4): 300060519893870.
[33]	Zhu WY, She WD, Gao ZW, et al. Inhibition of macrophage migration inhibitory factor alleviates LPS-induced inflammation response of HEI-OC1 cells via suppressing NF-κB signaling[J]. Cytokine, 2022, 150: 155776. doi: 10.1016/j.cyto.2021.155776
[34]	Yao J, Leng L, Fu WL, et al. ICBP90 regulates MIF expression, glucocorticoid sensitivity, and apoptosis at the MIF immune susceptibility locus[J]. Arthritis Rheumatol, 2021, 73(10): 1931-1942. doi: 10.1002/art.41753
[35]	Kariya S, Okano M, Maeda Y, et al. Role of macrophage migration inhibitory factor in age-related hearing loss[J]. Neuroscience, 2014, 279: 132-138. doi: 10.1016/j.neuroscience.2014.08.042
[36]	Zhu WY, Jin X, Ma YC, et al. MIF protects against oxygen-glucose deprivation-induced ototoxicity in HEI-OC1 cochlear cells by enhancement of Akt-Nrf2-HO-1 pathway[J]. Biochem Biophys Res Commun, 2018, 503(2): 665-670. doi: 10.1016/j.bbrc.2018.06.058
[37]	Mao YJ, Chen HH, Wang B, et al. Increased expression of MUC5AC and MUC5B promoting bacterial biofilm formation in chronic rhinosinusitis patients[J]. Auris Nasus Larynx, 2015, 42(4): 294-298. doi: 10.1016/j.anl.2014.12.004
[38]	钟烁, 苗伟. 慢性鼻-鼻窦炎伴鼻息肉患者鼻黏膜组织HIF-1α、MUC5AC表达与糖皮质激素抵抗的关系[J]. 新疆医科大学学报, 2023, 46(4): 441-446. https://www.cnki.com.cn/Article/CJFDTOTAL-XJYY202304003.htm
[39]	Jiang LJ, Zhou M, Deng J, et al. The ratio of 11β-hydroxysteroid dehydrogenase 1/11β-hydroxysteroid dehydrogenase 2 predicts glucocorticoid response in nasal polyps[J]. Eur Arch Otorhinolaryngol, 2019, 276(1): 131-137. doi: 10.1007/s00405-018-5201-3
[40]	Lu HG, Lin XS, Yao DM, et al. Increased serum amyloid A in nasal polyps is associated with systemic corticosteroid insensitivity in patients with chronic rhinosinusitis with nasal polyps: a pilot study[J]. Eur Arch Otorhinolaryngol, 2018, 275(2): 401-408. doi: 10.1007/s00405-017-4809-z
[41]	Taha MS, Nocera A, Workman A, et al. P-glycoprotein inhibition with verapamil overcomes mometasone resistance in Chronic Sinusitis with Nasal Polyps[J]. Rhinology, 2021, 59(2): 205-211.