耳甲腔毛母细胞瘤1例并文献复习

李雪雪, 卫旭东, 李淑娟, 等. 耳甲腔毛母细胞瘤1例并文献复习[J]. 临床耳鼻咽喉头颈外科杂志, 2024, 38(5): 448-452. doi: 10.13201/j.issn.2096-7993.2024.05.019
引用本文: 李雪雪, 卫旭东, 李淑娟, 等. 耳甲腔毛母细胞瘤1例并文献复习[J]. 临床耳鼻咽喉头颈外科杂志, 2024, 38(5): 448-452. doi: 10.13201/j.issn.2096-7993.2024.05.019
LI Xuexue, WEI Xudong, LI Shujuan, et al. A case of trichoblastoma of the auricular cavity and review of the literature[J]. J Clin Otorhinolaryngol Head Neck Surg, 2024, 38(5): 448-452. doi: 10.13201/j.issn.2096-7993.2024.05.019
Citation: LI Xuexue, WEI Xudong, LI Shujuan, et al. A case of trichoblastoma of the auricular cavity and review of the literature[J]. J Clin Otorhinolaryngol Head Neck Surg, 2024, 38(5): 448-452. doi: 10.13201/j.issn.2096-7993.2024.05.019

耳甲腔毛母细胞瘤1例并文献复习

详细信息

A case of trichoblastoma of the auricular cavity and review of the literature

More Information
  • 毛母细胞瘤(trichoblastoma,TB)是一种罕见的毛发生殖细胞皮肤附件肿瘤,罕见的皮肤滤泡肿瘤,分化于毛胚上皮,常被视为良性皮肤肿瘤,但局限性差且具有局部浸润性生长模式。TB好发于头部和颈部区域,尤其是面部,临床表现为生长缓慢、边界清晰及隆起的结节。TB常规以手术治疗为主,由于目前缺乏普遍接受的治疗指南或方案,术后复发率高,为临床治愈增加了一定的难度。本研究报道1例65岁女性患者,发现右侧外耳道口及耳甲腔肿物并反复破溃流脓,最初误诊为外耳道炎,以常规抗感染治疗,症状未缓解并逐渐加重后来我院就诊。该病例所展现的病症极为罕见,因此,及时且准确的诊断与治疗对此类疫病的诊疗和预后至关重要。
  • 加载中
  • 图 1  术前耳甲腔图

    图 2  术前内耳CT图

    图 3  耳甲腔病损局部活检病理切片

    图 4  术中皮瓣移植

    图 5  术后2 d

    图 6  术后1周

    图 7  术后1个月

    图 8  术后病理切片

  • [1]

    Cao Z, Liu Y, Wei G, et al. Basal Cell Carcinoma or Trichoblastoma? Two Cases of Nasal Nodules Difficult to Distinguish[J]. Indian J Dermatol, 2022, 67(4): 448-450.

    [2]

    Sławińska M, Płaszczyńska A, Lakomy J, et al. Significance of Dermoscopy in Association with Clinical Features in Differentiation of Basal Cell Carcinoma and Benign Trichoblastic Tumours[J]. Cancers(Basel), 2022, 14(16): 3964.

    [3]

    Kolm I, Kastnerova L, Konstantinova AM, et al. Trichoblastoma: A Consecutive Series of 349 Sporadic Cases Analyzed by Ackerman Subtypes[J]. Am J Dermatopathol, 2021, 43(12): 887-897. doi: 10.1097/DAD.0000000000001895

    [4]

    Pampena R, Peccerillo F, Marghoob NG, et al. Peritumoural clefting as a key feature in differentiating basal cell carcinoma from trichoblastoma through in vivo reflectance confocal microscopy[J]. J Eur Acad Dermatol Venereol, 2019, 33(5): e201-e203.

    [5]

    Boettler MA, Shahwan KT, Abidi NY, et al. Trichoblastic carcinoma: a comprehensive review of the literature[J]. Arch Dermatol Res, 2022, 314(5): 399-403. doi: 10.1007/s00403-021-02241-y

    [6]

    Zeller KA, Billmire DF. Trichoblastoma: management of a rare skin lesion[J]. J Pediatr Surg, 2012, 47(1): 250-252. doi: 10.1016/j.jpedsurg.2011.10.068

    [7]

    Pitarch G, Botella-Estrada R. Dermoscopic Findings in Trichoblastoma[J]. Actas Dermosifiliogr, 2015, 106(9): e45-e48. doi: 10.1016/j.ad.2015.01.017

    [8]

    Loh SH, Lew BL, Sim WY. Composite Tumor Associating Trichoblastoma and Seborrheic Keratosis[J]. Ann Dermatol, 2015, 27(5): 601-604. doi: 10.5021/ad.2015.27.5.601

    [9]

    Kim HC, Sohng SH, Shin DH, et al. Immunohistochemical expression of cytokeratin 15, cytokeratin 19, follistatin, and Bmi-1 in basal cell carcinoma[J]. Int J Dermatol, 2016, 55(1): 36-44. doi: 10.1111/ijd.12771

    [10]

    Umbert P, Muñoz JF. False-negative tumor-free margins following mohs surgery for aggressive trichoblastoma[J]. Am J Dermatopathol, 2012, 34(3): 255-258. doi: 10.1097/DAD.0b013e318213f80d

    [11]

    Giang J, Mooyaart AL, Martens-de Kemp SR, et al. Hedgehog pathway mutations are involved in the pathogenesis of plaque-type "trichoblastoma": A report of two cases[J]. J Cutan Pathol, 2023, 50(7): 674-680. doi: 10.1111/cup.14389

    [12]

    Rashid M, van der Horst M, Mentzel T, et al. ALPK1 hotspot mutation as a driver of human spiradenoma and spiradenocarcinoma[J]. Nat Commun, 2019, 10(1): 2213. doi: 10.1038/s41467-019-09979-0

    [13]

    Pickering CR, Zhou JH, Lee JJ, et al. Mutational landscape of aggressive cutaneous squamous cell carcinoma[J]. Clin Cancer Res, 2014, 20(24): 6582-6592. doi: 10.1158/1078-0432.CCR-14-1768

    [14]

    South AP, Purdie KJ, Watt SA, et al. NOTCH1 mutations occur early during cutaneous squamous cell carcinogenesis[J]. J Invest Dermatol, 2014, 134(10): 2630-2638. doi: 10.1038/jid.2014.154

    [15]

    Kervarrec T, Pissaloux D, Poilane J, et al. Recurrent FOXK1: : GRHL and GPS2: : GRHL fusions in trichogerminoma[J]. J Pathol, 2022, 257(1): 96-108. doi: 10.1002/path.5872

    [16]

    Pogorzelska-Antkowiak A, Antkowiak R, Poloczek R. Trichoblastoma in reflectance confocal microscopy[J]. Australas J Dermatol, 2023, 64(1): e89-e90.

    [17]

    Kocaman N, Yuksel EI, Demir B, et al. Two Novel Biomarker Candidates for Differentiating Basal Cell Carcinoma from Trichoblastoma; Asprosin and Meteorine Like Peptide[J]. Tissue Cell, 2022, 76: 101752. doi: 10.1016/j.tice.2022.101752

    [18]

    Patel P, Nawrocki S, Hinther K, et al. Trichoblastomas Mimicking Basal Cell Carcinoma: The Importance of Identification and Differentiation[J]. Cureus, 2020, 12(5): e8272.

    [19]

    Demant M, Saltvig I, Trøstrup H, et al. Don't Judge a Tumor by Its Biopsy![J]. Case Rep Dermatol, 2020, 12(3): 266-274. doi: 10.1159/000509764

    [20]

    Requena C, Requena L, Kazakov DV, et al. Multiple facial plaque variant of trichoblastoma[J]. J Cutan Pathol, 2019, 46(4): 285-289. doi: 10.1111/cup.13416

    [21]

    Weiland T, Sadoghi B, Pondorfer P, et al. Trichoblastic carcinosarcoma of the neck: Case report and molecular analysis of a seldom, relapsing entity and a review of the literature[J]. J Dermatol, 2023, 50(5): 700-704. doi: 10.1111/1346-8138.16716

    [22]

    Vega Memije ME, Luna EM, de Almeida OP, et al. Immunohistochemistry panel for differential diagnosis of Basal cell carcinoma and trichoblastoma[J]. Int J Trichology, 2014, 6(2): 40-44. doi: 10.4103/0974-7753.138583

    [23]

    夏鹏, 吴发印, 黄志权, 等. 巨大结节与角化型面部基底细胞癌1例[J]. 临床耳鼻咽喉头颈外科杂志, 2022, 36(4): 307-309. https://lceh.whuhzzs.com/article/doi/10.13201/j.issn.2096-7993.2022.04.015

    [24]

    Bi Y, Shi X, Chen D, et al. CD133, but Not CD44, May Serve as a Novel Biomarker for Differential Diagnosis Between Basal Cell Carcinoma and Trichoblastomas[J]. Clin Cosmet Investig Dermatol, 2022, 15: 1517-1526. doi: 10.2147/CCID.S373331

    [25]

    Zhang ZC, Hu J, Kong YY, et al. [Application of immunohistochemical staining of bcl-2, Ber-EP4, CD10, CK20, and Ki-67 in differential diagnosis between trichoblastoma and basal cell carcinoma][J]. Zhonghua Bing Li Xue Za Zhi, 2021, 50(4): 376-381.

    [26]

    Stanoszek LM, Wang GY, Harms PW. Histologic Mimics of Basal Cell Carcinoma[J]. Arch Pathol Lab Med, 2017, 141(11): 1490-1502. doi: 10.5858/arpa.2017-0222-RA

    [27]

    Battistella M, Peltre B, Cribier B. PHLDA1, a follicular stem cell marker, differentiates clear-cell/granular-cell trichoblastoma and clear-cell/granular cell basal cell carcinoma: a case-control study, with first description of granular-cell trichoblastoma[J]. Am J Dermatopathol, 2014, 36(8): 643-650. doi: 10.1097/DAD.0b013e31828a31ae

    [28]

    Owen JL, Liu W, Croitoru A, et al. Aggressive subcutaneous trichoblastomas successfully treated with Mohs micrographic surgery[J]. Australas J Dermatol, 2019, 60(3): e249-e251.

    [29]

    Fusumae T, Tanese K, Takeuchi A, et al. High-grade trichoblastic carcinoma arising through malignant transformation of trichoblastoma: Immunohistochemical analysis and the expression of p53 and phosphorylated AKT[J]. J Dermatol, 2019, 46(1): 57-60. doi: 10.1111/1346-8138.14686

    [30]

    Leblebici C, Bambul Sıǧırcı B, Kelten Talu C, et al. CD10, TDAG51, CK20, AR, INSM1, and Nestin Expression in the Differential Diagnosis of Trichoblastoma and Basal Cell Carcinoma[J]. Int J Surg Pathol, 2019, 27(1): 19-27. doi: 10.1177/1066896918781719

    [31]

    Pozo L, Diaz-Cano SJ. Trichogerminoma: further evidence to support a specific follicular neoplasm[J]. Histopathology, 2005, 46(1): 108-110. doi: 10.1111/j.1365-2559.2005.01955.x

    [32]

    Leeman A, de Cuba E, Jaspars LH, et al. A Low-Grade Trichoblastic Carcinoma Treated with Mohs Micrographic Surgery[J]. Case Rep Dermatol, 2021, 13(1): 129-133. doi: 10.1159/000512871

    [33]

    Al Mushcab N, Husain R, Al Subaiei M, et al. Trichoblastoma mimicking basal cell carcinoma and the approach to its management: Case report[J]. Int J Surg Case Rep, 2021, 86: 106318. doi: 10.1016/j.ijscr.2021.106318

    [34]

    Tellechea O, Cardoso JC, Reis JP, et al. Benign follicular tumors[J]. An Bras Dermatol, 2015, 90(6): 780-796. doi: 10.1590/abd1806-4841.20154114

  • 加载中

(8)

计量
  • 文章访问数:  268
  • PDF下载数:  41
  • 施引文献:  0
出版历程
收稿日期:  2023-08-11
刊出日期:  2024-05-03

目录