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Abstract: Chronic rhinosinusitis(CRS), asthma and chronic obstructive pulmonary disease(COPD) are common chronic airway inflammatory diseases, which seriously affect patients' quality of life and bring heavy economic and social burden. Interleukin(IL) -8 is an important chemokine of neutrophils and other inflammatory cells, which plays an important role in the development of chronic airway inflammation. In this review, the inflammatory mechanisms involved in regulating IL-8 gene expression and the role of IL-8 in different airway chronic inflammation were reviewed.
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Key words:
- airway inflammation /
- interleukin-8 /
- pathogenesis
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