Analysis of esophageal manometry results and the inflection point of age in 41 volunteers without laryngopharyngeal symptoms
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摘要: 目的 探讨不同年龄食管压力的差异, 同时分析食管动力生理性退化的可能年龄拐点, 进一步评估随着年龄增长食管动力学的退化是否是咽喉反流性疾病(LPRD)发生的唯一危险因素。方法 对41例无咽喉症状的志愿者进行固态高分辨率食管测压, 将其结果与芝加哥标准进行比对, 并比较预设年龄拐点组间人群的食管测压结果。结果 大部分志愿者的食管测压结果均符合芝加哥标准。其中, 以55岁为年龄拐点分组, 两组间各项食管动力学数据分析结果均P>0.05;以65岁为年龄拐点分组, 两组间食管上括约肌长度及收缩前沿速度的差异有统计学意义(P = 0.021及0.046)。结论 随着年龄的增长, 无咽喉反流症状人群中食管动力会发生一定程度的退化, 这种变化在65岁后较为明显, 但仍在正常范围内。食管动力学的退变不是LPRD发生的唯一危险因素。Abstract: Objective This study aimed to explore the differences in esophageal pressure at different ages, and to analyze the possible age inflection points of the physiological degeneration of esophageal motility, and to further evaluate whether the degeneration of esophageal kinetics with age is the only risk factor for the occurrence of throat reflux disease (LPRD).Methods A solid-state high-resolution esophageal pressure measurement was performed on 41 volunteers without throat symptoms. The Chicago classification data were compared with the manometry results of all volunteers. In addition, the esophageal manometry results were compared among groups with pre-set age inflection point.Results Most of the volunteers' esophageal pressure measurements were in line with Chicago standards. When the inflection point of age was 55 years, no significant difference was found between the two groups. However, when the inflection point of age was 65 years, a significant difference in the length of the upper esophageal sphincter and the contractile front velocity was found between the two groups(P = 0.021 and 0.046 respectively).Conclusion Esophageal dynamics was weakened with increasing age in the volunteers without laryngopharyngeal symptoms, which was more obvious after the age of 65, but still within the normal range. The degeneration of esophageal motility is not the only risk factor for LPRD.
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表 1 41例无咽喉症状志愿者食管动力结果与正常值的比较
观察指标 志愿者 正常者 UES静息压/mmHg 61.63±25.03 40~140 UES长度/cm 3.34±0.49 3~4 LES静息压/mmHg 16.61±7.12 10~30 CFV/(cm·s-1) 4.21±0.72 < 9 DCI/(mmHg·s-1·cm-1) 934.41±585.93 450~8000 蠕动中断/cm 1.54±2.81 < 5 DL/s 6.44±0.81 ≥4.5 
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