顺铂耳毒性与自噬关系的研究进展

梁峥嵘; 程贵; 张涛; 贾海英

doi:10.13201/j.issn.1001-1781.2020.02.023

顺铂耳毒性与自噬关系的研究进展

- 1.
  暨南大学第一临床医学院(广州，510000)
- 2.
  暨南大学附属第一医院耳鼻咽喉科

详细信息

通讯作者: 贾海英，E-mail：1399728486@qq.com

^△审校者

中图分类号: R764

收稿日期: 2019-05-04

刊出日期: 2020-02-05

Research progress on the relationship between cisplatin ototoxicity and autophagy

More Information

Corresponding author: JIA Haiying, E-mail: 1399728486@qq.com

Received Date: 04 May 2019

Publish Date: 05 February 2020

摘要

- 顺铂 /
- 耳毒性 /
- 自噬
Abstract: Summary Cisplatin is an anti-tumor drug which is widely used for the treatment of various solid tumors. Unfortunately, seriousside-effects have affected patients, such as hearing loss. Up to now, there is no clear and effective measure to protect the cisplatin-induced ototoxicity in the clinical use of cisplatin studies indicated that autophagy may be involved in the whole process of cisplatin-induced hearing loss. In this review, the relationship between cisplatin ototoxicity and autophagy was reviewed. It is hoped that this study can provide reference for further study of cisplatin ototoxicity and intervention of autophagy with autophagy activator or inhibitor.
- cisplatin /
- ototoxicity /
- autophagy

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