Analysis of the effect of endoscopic surgery combined with conventional surgery in Neuroblastoma
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摘要: 目的 探讨内镜手术与传统手术联合放射治疗嗅神经母细胞瘤的疗效。方法 回顾分析43例接受手术联合放疗的嗅神经母细胞瘤患者疗效，按照手术方式分为内镜手术与传统手术，所有患者术后均接受放疗，放疗剂量60~70 Gy，对2组患者的5年生存率、局部复发时间进行比较，对比内镜手术与传统手术的治疗效果。结果 通过生存分析，开放手术组与内镜手术组5年总体生存率分别为50%和58%(P=0.560)；局部复发率分别为44%与48%(P=0.288)，平均复发时间分别为5.6个月与12.5个月(P=0.032)。结论 内镜手术与传统手术联合放疗治疗嗅神经母细胞瘤疗效无差异，且局部复发时间显著延长，在早期嗅神经母细胞瘤患者诊治中，鼻内镜手术治疗效果和患者生存治疗方面可能优于开放手术。Abstract: Objective The aim of this study is to evaluate the efficacy of endoscopic surgery and conventional surgery combined with radiotherapy in the treatment of Neuroblastoma.Method Forty-three patients with olfactory neuroblastoma undergoing surgery combined with radiotherapy were retrospectively analyzed. The patients were divided into endoscopic surgery and conventional surgery. All patients received postoperative radiotherapy at a dose of 60-70 Gy, the 5-year survival rate and local recurrence time of the two groups were compared, and the therapeutic effects of endoscopic surgery and traditional surgery were compared.Result Through survival analysis, the 5-year overall survival rates of the traditional surgery group and the endoscopic surgery group were 50% and 58% (P=0.560), the local recurrence rates were 44% and 48% (P=0.288), and the mean recurrence time was 5.6 months and 12.5 months (P=0.032).Conclusion There was no difference between endoscopic surgery and conventional surgery combined with radiotherapy in the treatment of Neuroblastoma, and the time of local recurrence was significantly prolonged. In early Neuroblastoma, endoscopic sinus surgery may be superior to open surgery in terms of efficacy and patient survival.
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Key words:
- esthesioneuroblastoma /
- radiation therapy /
- treatment effect
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