初次咀嚼综合征6例临床分析及文献复习

黄石; 黄朝平; 沈朝勇; 林艳; 王轶

doi:10.13201/j.issn.1001-1781.2019.12.019

初次咀嚼综合征6例临床分析及文献复习

- 1. 成都医学院第一附属医院耳鼻咽喉头颈外科(成都, 610500);
- 2. 四川大学华西医院胃肠外科

详细信息

通讯作者: 王轶,E-mail:116372016@qq.com

中图分类号: R739.91

收稿日期: 2019-05-16

First bite syndrome: clinical study of six cases and review of the literature

- 1 Department of Otorhinolaryngology Head and Neck Surgery, the First Affiliated Hospital of Chengdu Medical College, Chengdu, 610500, China;
- 2 Department of Gastrointestinal Surgery, West China Hospital, Sichuan University

More Information

Corresponding author: WANG Yi, E-mail: 116372016@qq.com

Received Date: 16 May 2019

摘要

摘要: 目的:探讨初次咀嚼综合征(FBS)的病因、诊断及治疗方法。方法:回顾性分析6例FBS患者的临床资料。6例患者中,咽旁间隙肿瘤切除术并发FBS者4例,腮腺深叶肿瘤切除术并发FBS者1例,无明确病因1例。给予布洛芬及曲马多胶囊等止痛药治疗,合用卡马西平(200 mg,每天3次),连续4周。结果:5例患者于治疗结束后2~16个月缓解,另1例患者随访10个月症状无明显缓解。结论:FBS多为上颈部肿瘤切除术尤其是腮腺深叶肿瘤切除术可能出现的并发症之一,需与术后疼痛相区别。发病原因可能与术中损伤腮腺交感神经丛相关,目前尚无规范的治疗方法,但症状多在数月内缓解。
- 初次咀嚼综合征 /
- 药物疗法 /
- 并发症
Abstract: Objective: The aim of this study is to explore the etiology, diagnosis and treatment of first bite syndrome(FBS). Method: Clinical data of six patients with FBS were analyzed retrospectively. There were 4 cases of parapharyngeal space tumor resection complicated with FBS, 1 case of parotidectomy of deep lobe parotid gland tumor complicated with FBS, and 1 case of no definite cause. Analgesic treatments such as ibuprofen and tramadol capsules were given, in combination with carbamazepine(200 mg, 3 times a day) for four weeks. Result: The severity of symptoms decreased in five cases, 2-16 months after treatment. While another one had no amelioration during 10 months' follow-up.Conclusion: FBS is one of the possible complications of surgery of the upper cervical region, especially parotid deep lobe tumor resection, which should be distinguished from the usual postoperative pain. The cause of the disease may be related to intraoperative injury to the sympathetic plexus of the parotid gland. Currently, there is no standard treatment method, but the symptoms are usually relieved within a few months.
- first bite syndrome /
- drug therapy /
- complication

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参考文献(21)

[1]	HAUBRICH W S.The first-bite syndrome[J].Henry Ford Hosp Med J,1986,34:275-278.
[2]	LACCOURREYE O,WERNER A,GARCIA D,et al.First bite syndrome[J].Eur Ann Otorhinolaryngol Head Neck Dis,2013,130:269-273.
[3]	FIACCHINI G,CERCHIAI N,TRICÒ D,et al.Frey Syndrome,First Bite Syndrome,great auricular nerve morbidity,and quality of life following parotidectomy[J].Eur Arch Otorhinolaryngol,2018,275:1893-1902.
[4]	AVINÇSAL M Ö,HIROSHIMA Y,SHINOMIYA H,et al.First bite syndrome-An 11-year experience[J].Auris Nasus Larynx,2017,44:302-305.
[5]	黄石,黄朝平,候楠,等.咽旁间隙肿瘤术后并发初次咀嚼症候群2例[J].临床耳鼻咽喉头颈外科杂志,2019,33(1):81-84.
[6]	黄朝平,刘良发,路承,等.咽旁间隙肿瘤术后并发初次咀嚼综合征二例[J].中华耳鼻咽喉头颈外科杂志,2018,53(7):532-534.
[7]	PHILLIPS T J,FARQUHAR-SMITH W P.Pharmacological treatment of a patient with first-bite syndrome[J].Anaesthesia,2009,64:97-98.
[8]	NETTERVILLE J L,JACKSON C G,MILLER F R,et al.Vagal paraganglioma:a review of 46 patients treated during a 20-year period[J].Arch Otolaryngol Head Neck Surg,1998,124:1133-1140.
[9]	CHIU A G,COHEN J I,BURNINGHAM A R,et al.First bite syndrome:a complication of surgery involving the parapharyngeal space[J].Head Neck,2002,24:996-999.
[10]	KAWASHIMA Y,SUMI T,SUGIMOTO T,et al.First-bite syndrome:A review of 29 patients with parapharyngeal space tumor[J].Auris Nasus Larynx,2008,35:109-113.
[11]	LINKOV G,MORRIS L G,SHAH J P,et al.First bite syndrome:Incidence,risk factors,treatment,and outcomes[J].Laryngoscope,2012,122:1773-1778.
[12]	DEGANELLO A,MECCARIELLO G,BUSONI M,et al.First bite syndrome as presenting symptom of parapharyngeal adenoid cystic carcinoma[J].J Laryngol Otol,2011,125:428-431.
[13]	LIEBERMAN S M,HAR-EL G.First bite syndrome as a presenting symptom of a parapharyngeal space malignancy[J].Head Neck,2011,33:1539-1541.
[14]	GUSS J,ASHTON-SAGER A L,FONG B P.First bite syndrome caused by adenoid cystic carcinoma of the submandibular gland[J].Laryngoscope,2013,123:426-428.
[15]	STOOPLER E T,ELMURADI S,SOLLECTIO T P,et al.Idiopathic First Bite Syndrome[J].J Oral Maxillofac Surg,2016,74:872-872.
[16]	MANDEL L,SYROP S B.First-bite syndrome after parapharyngeal surgery for cervical schwannoma[J].J Am Dent Assoc,2008,139:1480-1483.
[17]	SIMS J R,SUEN J Y.First bite syndrome:case report of 3 patients treated with botulinum toxin and review of other treatment modalities[J].Head Neck,2013,35:E288-E291.
[18]	GHOSH A,MIRZA N.First bite syndrome:Our experience with intraparotid injections with botulinum toxin type A[J].Laryngoscope,2016,126:104-107.
[19]	AMIN N,PELSER A,WEIGHILL J.First bite syndrome:our experience of laser tympanic plexus ablation[J].J Laryngol Otol,2014,128:166-168.
[20]	SHARMA P K,MASSEY B L.Gabapentin for the Treatment of First Bite Syndrome Following Parapharyngeal Space Surgery[J].Otolaryngol Head Neck Surg,2005,133:173-173.
[21]	ALI M J,ORLOFF L A,LUSTIG L R,et al.Botulinum toxin in the treatment of first bite syndrome[J].Otolaryngol Head Neck Surg,2008,139:742-743.