<sup>18</sup>F-FDG用于评估外伤性嗅神经损伤对药物经鼻脑通路运输的影响

苏百晗; 孙智甫; 陈忠维; 朱紫薇; 高星; 张晓丽; 魏永祥

doi:10.13201/j.issn.1001-1781.2019.12.008

¹⁸F-FDG用于评估外伤性嗅神经损伤对药物经鼻脑通路运输的影响

- 1. 首都医科大学附属北京安贞医院耳鼻咽喉头颈外科(北京, 100029);
- 2. 北京GE公司;
- 3. 首都医科大学附属北京安贞医院核医学科
基金项目:
国家自然科学基金(No:81670903)

详细信息

通讯作者: 魏永祥,E-mail:weiyongxiang67@126.com

中图分类号: R765.6

收稿日期: 2019-06-20

Using of ¹⁸F-FDG to evaluate the effect of traumatic olfactory nerve injury on drug delivery through the nasal-brain pathway: a PET-MRI pilot study

- 1 Department of Otolaryngology Head and Neck Surgery, Capital Medical University Affiliated Anzhen Hospital, Beijing, 100029, China;
- 2 GE Healthcare of Beijing;
- 3 Department of Nuclear Medicine, Capital Medical University Affiliated Anzhen Hospital

More Information

Corresponding author: WEI Yongxiang, E-mail: weiyongxiang67@126.com

Received Date: 20 June 2019

摘要

摘要: 目的:通过嗅裂区滴注氟代脱氧葡萄糖(¹⁸F-FDG)评估外伤性嗅神经损伤对经鼻给药后药物经鼻脑通路运输的影响。方法:招募7例嗅觉功能正常志愿者(正常组)和5例外伤性嗅觉障碍患者(嗅觉障碍组),于鼻内镜下嗅裂区滴入¹⁸F-FDG,12 h后行PET/MRI扫描,分析2组之间嗅球直径、嗅球感兴趣区摄取量等参数的影响。结果:¹⁸F-FDG直接接触筛板与未直接接触筛板时嗅球感兴趣区摄取量在正常组(P=0.012 7)和嗅觉障碍组(P=0.038 1)中的差异均有统计学意义。正常组与嗅觉障碍组嗅裂内¹⁸F-FDG直接与筛板接触侧的嗅球摄取量无明显差异(P=0.937 2)。结论:外伤性嗅觉障碍患者嗅球明显萎缩,嗅球感兴趣区对¹⁸F-FDG的摄取也随之降低,¹⁸F-FDG经嗅裂区给药可以通过鼻脑通路进入嗅球及嗅球旁组织,嗅神经元的离断损伤对¹⁸F-FDG经鼻脑通路进入中枢神经系统的影响并不明显。
- 氟代脱氧葡萄糖 /
- 嗅神经 /
- 鼻脑通路 /
- 嗅觉障碍 /
- 正电子发射计算机断层显像
Abstract: Objective: This study evaluated the effect of traumatic olfactory nerve injury on drug delivery through the nasal-brain pathway via the instillation of ¹⁸F-FDG at the olfactory cleft. Method: Seven healthy volunteers and 5 patients with traumatic dysosmia were enrolled in the study. Subjects were all instilled with ¹⁸F-FDG on each side of the olfactory cleft under endoscopy. After 12 hours, a PET/MR scan was performed to track the metabolism pathway of ¹⁸F-FDG. Then, we compared the diameter of the olfactory bulb and the olfactory bulb intake between normal volunteers and patients with traumatic olfactory disorders. Result: In healthy volunteers, there was a significant difference in ¹⁸F-FDG uptake between the regions of interest in which ¹⁸F-FDG was or was not in contact with the cribriform plate(P=0.012 7); this difference also existed in patients with traumatic olfactory disorders(P=0.038 1). Patients with traumatic olfactory disorders did not exhibit significant differences in ¹⁸F-FDG uptake in the region of interest compared with healthy volunteers(P=0.937 2).Conclusion: The olfactory bulb is obviously atrophied in patients with traumatic olfactory dysfunction, and the uptake of ¹⁸F-FDG in the olfactory bulb region of interest is also reduced. The administration of ¹⁸F-FDG via olfactory fissure area can enter olfactory bulb and parafrontal tissues through the nasal brain pathway, ¹⁸F-FDG can enter the central nervous system through the nasal-brain pathway, which is not affected by olfactory nerve transection injury.
- 18F-FDG /
- olfactory nerve /
- nasal-brain pathway /
- olfaction disorders /
- PET/MR

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