绝经后BPPV女性血清雌二醇及Otolin-1水平的变化

冯美艳; 庄建华; 顾欢欢; 田青; 张照环

doi:10.13201/j.issn.1001-1781.2019.12.006

绝经后BPPV女性血清雌二醇及Otolin-1水平的变化

- 海军军医大学附属长征医院神经内科(上海, 200003)
基金项目:
上海市科学技术委员会科研计划项目(No:18ZR1439200)

详细信息

通讯作者: 庄建华,E-mail:jianhuazh11@126.com

中图分类号: R764.3

收稿日期: 2019-03-21

Changes of serum E2 and Otolin-1 levels in postmenopausal women with BPPV

- Department of Neurology, Shanghai Changzheng Hospital of Navy Medical University, Shanghai, 200003, China

More Information

Corresponding author: ZHUANG Jianhua, E-mail: jianhuazh11@126.com

Received Date: 21 March 2019

摘要

摘要: 目的:探讨绝经后女性BPPV患者血清中雌二醇(E2)及耳石蛋白Otolin-1水平的变化。方法:选取明确诊断为原发性BPPV的绝经后女性患者40例作为试验组,同期绝经后无眩晕女性40例为对照组。抽取清晨空腹外周静脉血4 ml,分别采用电化学发光方法和ELISA检测2组研究对象血清中E2和Otolin-1蛋白的水平。结果:①试验组和对照组血清中E2水平分别为(29.11±15.11) pg/ml和(37.18±12.24) pg/ml(P=0.010);②试验组和对照组血清中Otolin-1水平分别为(361.55±186.14) pg/ml和(282.61±139.98) pg/ml(P=0.035)。③分别对试验组和对照组血清中Otolin-1和E2水平进行Spearman相关分析,二者均不存在相关性(P分别为0.403和0.363)。④对照组中,年龄与血清中E2水平呈负相关(P=0.044,r=-0.320),提示年龄与E2水平仅低度相关;在试验组中,二者无相关性(P=0.148)。⑤试验组和对照组的年龄与血清中Otolin-1水平无相关性(P分别为0.705和0.076)。结论:与绝经后无眩晕女性患者相比,绝经后BPPV女性患者血清中E2水平下降,Otolin-1水平明显升高,推测血清中Otolin-1蛋白水平或可作为血清学标志物,以辅助绝经后女性BPPV的诊断和疗效评估。
- 眩晕 /
- 绝经后女性 /
- 雌二醇 /
- Otolin-1 /
- 生物标志物
Abstract: Objective: To investigate the changes of serum estradiol(E2) and otolith structural protein Otolin-1 levels in postmenopausal women with benign paroxysmal positional vertigo(BPPV). Method: Forty postmenopausal women diagnosed as primary BPPV were selected as the experimental group. Meanwhile, 40 postmenopausal women without vertigo during the same time were selected as the control group. 4 ml of fasting peripheral venous blood was extracted in the morning, and E2 and Otolin-1 protein levels in serum of the two groups were detected by electrochemiluminescence(ECL) and ELISA, respectively. Result: ①The serum level of E2 in the experimental group was(29.11±15.11) pg/ml, which was lower than that in the control group(37.18±12.24) pg/ml(P=0.010). ②The serum level of Otolin-1 in the experimental group was(361.55±186.14) pg/ml, which was significantly higher than that in the control group(282.61±139.98) pg/ml(P=0.035). ③Spearman correlation analysis was carried out on the serum levels of Otolin-1 and E2 in the experimental group and the control group, respectively, and no correlation was found between them(P=0.403 and 0.363, respectively). ④In the control group, age was negatively correlated with serum E2 level(P=0.044, r=-0.320), suggesting that age was only weakly correlated with E2 level. However, in the experimental group, there was no correlation between the two(P=0.148). ⑤There was no correlation between age and serum Otolin-1 level in the two groups(P=0.705 and 0.076, respectively).Conclusion: Compared with postmenopausal patients without vertigo, the level of E2 in postmenopausal BPPV patients decreased, but the level of Otolin-1 increased significantly. Therefore, the serum level of Otolin-1 may be used as a bio-marker to assist the diagnosis and efficacy evaluation of postmenopausal women with BPPV.
- vertigo /
- postmenopausal women /
- estradiol /
- Otolin-1 /
- bio-marker

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