BRAP在喉鳞状细胞癌中的表达及其与预后的相关性

殷文娟; 李灵敏; 王丽; 黄安; 乔爱秀; 贾宇婷; 冯彦

doi:10.13201/j.issn.1001-1781.2019.11.018

BRAP在喉鳞状细胞癌中的表达及其与预后的相关性

- 1. 山西医科大学基础医学院病理教研室(太原, 030001);
- 2. 晋中市第一人民医院耳鼻咽喉科;
- 3. 山西医科大学第一医院耳鼻咽喉头颈外科
基金项目:
中国博士后科学基金(No:2016M591413)

山西医科大学大学生创新创业校级项目(No:20170327)

详细信息

通讯作者: 冯彦,E-mail:fengyan@sxmu.edu.cn

中图分类号: R739.65

收稿日期: 2019-04-17

Correlation between BRAP expression and prognosis of patients with laryngeal squamous cell carcinoma

- 1 Department of Pathology, Shanxi Medical University, Taiyuan, 030001, China;
- 2 Department of Otorhinolaryngology, the First People's Hospital of Jinzhong;
- 3 Department of Otorhinolaryngology Head and Neck Surgery, the First Hospital of Shanxi Medical University

More Information

Corresponding author: FENG Yan, E-mail: fengyan@sxmu.edu.cn

Received Date: 17 April 2019

摘要

摘要: 目的:检测BRAP在喉鳞状细胞癌(LSCC)组织中的表达,探讨其与临床病理特征及患者预后的相关性。方法:应用免疫组织化学和Western blot方法检测LSCC组织及癌旁正常组织中BRAP表达,统计学分析其与LSCC临床病理特征及预后的关系。结果:BRAP在LSCC组织中的表达显著高于癌旁正常组织(P<0.05)。BRAP表达与LSCC患者的TNM分期、淋巴结转移密切相关(均P<0.05);Kaplan-Meier分析显示BRAP高表达患者生存率明显低于BRAP低表达患者(P<0.01);多因素Cox回归分析提示BRAP是影响LSCC患者预后的独立危险因素。结论:BRAP与LSCC患者肿瘤进展和预后密切相关,BRAP有望成为LSCC评估预后的指标。
- 喉肿瘤 /
- 鳞状细胞癌 /
- BRAP /
- 免疫组织化学
Abstract: Objective: To investigate the expression of BRCA1 associated protein(BRAP) and its correlations with clinicopathological features and prognosis of patients with laryngeal squamous cell carcinoma(LSCC). Method: The protein expression of BRAP in LSCC tissues and normal laryngeal tissues were assessed by immunohistochemistry and Western blot, and their correlations with clinicopathological features and prognosis were statistically analyzed. Result: The expression of BRAP in LSCC was significantly higher than that in normal laryngeal tissues(P<0.05). BRAP expression was significantly correlated with the TNM stage and lymph node metastasis(P<0.05). Kaplan-Meier survival analysis showed that LSCC patients with high BRAP expression had worse overall survival than those with low BRAP expression(P<0.01). Multivariate Cox proportional-hazards analysis showed that the high expression of BRAP protein was an important poor prognostic indicator of the patients.Conclusion: BRAP is related with the development of LSCC, and it may be used as an important prognostic biomarker for LSCC patients.
- laryngeal neoplasms /
- squamous cell carcinoma /
- BRAP /
- immunohistochemistry

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