喉癌诊疗策略及进展

乐慧君; 陈思宇; 李芸; 徐扬; 雷文斌

doi:10.13201/j.issn.1001-1781.2019.11.003

喉癌诊疗策略及进展

- 中山大学附属第一医院耳鼻咽喉科医院广州市耳鼻咽喉科重点实验室(广州, 510080)
基金项目:
广东省科技计划项目(No:2017A050506018)

中山大学临床医学研究5010计划项目(No:2017004)

广州市科技计划项目(No:201704020092)

详细信息

通讯作者: 雷文斌,E-mail:leiwb@mail.sysu.edu.cn

中图分类号: R739.65

收稿日期: 2019-08-14

The progress on diagnosis and treatment of larynx cancer

More Information

Corresponding author: , E-mail: leiwb@mail.sysu.edu.cn

Received Date: 14 August 2019

摘要

摘要: 喉癌是头颈部常见恶性肿瘤之一,占全身恶性肿瘤的1%～5%,96%～98%为鳞状细胞癌。2015年中国新发喉癌26 400例,男女比例9∶1,死亡14 500例[1],发病人群以40岁以上中老年男性为主、略有年轻化趋势,不同种族和地域差异显著[2],我国华北和东北地区远高于南方各省。尽管流行病学资料显示全球喉癌发病率有所下降,但过去40年美国患者5年生存率由66%降至63%[3],提示治疗创新更有必要。喉癌的发生发展与多种因素作用相关,包
- 喉肿瘤 /
- 诊断 /
- 个体化治疗 /
- 综合治疗
Abstract: Laryngeal cancer remains one of the most common tumors of head and neck. While significant advancements have been made over the last several decades, diagnosis and treatment of laryngeal cancer presents an unique challenge given its complexity. It is essential to perform a thorough preoperative assessment by the dedicated multidisciplinary team(MDT), including confirmed diagnosis, accurate staging, surgical selection, rehabilitation and reconstruction, supportive care and postoperative follow-up. Surgery has been the historical mainstay for localized disease and still is an integral part of treatment, while transoral CO₂ laser microsurgery is being increasingly popularised in early stage tumors and occasionally in more advanced forms of the disease. Nonsurgical methods like radiation and systemic therapy have emerged as viable options in patients considered unfit for surgery or those who refuse it. In addition, novel targeted agents are showing promise for the population with metastases. Currently, a multimodal approach is preferred in advanced cases, but the optimal strategy remains under debate. Close follow-up is crucial in achieving early detection and being able to treat the recurrence with curative intention. In summary, all patients should have a comprehensive evaluation and treatment plan in a multidisciplinary setting. This highlights the need for further research and innovation in the field.
- laryngeal neoplasms /
- diagnosis /
- individual therapy /
- complex treatment

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