-
摘要: 1 前言口咽的上界为软腭口腔侧,下界至会厌谷,前界是舌根,外侧为扁桃体窝和咽侧壁,后界为咽后壁。可分为舌根、腭扁桃体、软腭口腔侧、咽后壁和咽侧壁五部分。口咽癌是指发生于软腭悬雍垂、腭扁桃体、舌根及口咽侧壁和后壁等部位的恶性肿瘤。口咽癌位于常见癌症的第10位,患者约占恶性肿瘤患者的5%[1]。口咽癌好发于中老年男性,病变位置75%以上发生于扁桃体,多为单侧发病,病理类型90%以上为鳞状细胞癌。口咽癌是一个全球性的公共卫生问题,具有重要Abstract: In recent years,human papillomavirus has been proved to be closely related to the occurrence and prognosis of oropharyngeal cancer.The treatment of oropharyngeal cancer has evolved from the primary radiotherapy to the corresponding treatment according to different tumor stages.For patients with advanced oropharyngeal cancer,the treatment strategy is mostly surgery + postoperative concurrent chemoradiotherapy.Patients are often accompanied by large defects in the surgical area after surgery.With the improvement of head and neck surgical repair technology and the progress of free flap technology,various repair methods can be adopted to repair and reconstruct.
-
Key words:
- oropharyngeal carcinoma /
- human papillomavirus /
- reconstruction
-
[1] RIVERA C.Essentials of oral cancer[J].Int J Clin Exp Pathol,2015,8:11884-11894.
[2] ZHAO D,XU Q G,CHEN X M,et al.Human papillomavirus as an independent predictor in oral squamous cell cancer[J].Int J Oral Sci,2009,1:119-125.
[3] ASTHANA S,LABANI S,KAILASH U,et al.Association of Smokeless Tobacco Use and Oral Cancer:A Systematic Global Review and Meta-Analysis[J].Nicotine Tob Res,2019,21:1162-1171.
[4] MEHRTASH H,DUNCAN K,PARASCANDOLA M,et al.Defining a global research and policy agenda for betel quid and areca nut[J].Lancet Oncol,2017,18:e767-e775.
[5] ZHANG LW,LI J,CONG X,et al.Incidence and mortality trends in oral and oropharyngeal cancers in China,2005-2013[J].Cancer Epidemiol,2018,57:120-126.
[6] FERLAY J,SOERJOMATARAM I,DIKSHIT R,et al.Cancer incidence and mortality worldwide:sources,methods and major patterns in GLOBOCAN2012[J].Int J Cancer,2015,136:E359-386.
[7] DU E,MAZUL A L,FARQUHAR D.Long-term Survival in Head and Neck Cancer:Impact of Site,Stage,Smoking,and Human Papillomavirus Status[J].Laryngoscope,2019:[Epub ahead of print].
[8] VAWDA N,BANERJEE R N,DEBENHAM B J.Impact of Smoking on Outcomes of HPV-related Oropharyngeal Cancer Treated with Primary Radiation or Surgery[J].Int J Radiat Oncol Biol Phys,2019,103:1125-1131.
[9] DALIANIS T.Human papillomavirus and oropharyngeal cancer,the epidemics,and significance of additionalclinical biomarkers for prediction of response to therapy(Review)[J].Int J Oncol,2014,44:1799-1805.
[10] SYRJÄNEN K,SYRJÄNEN S,LAMBERG M,et al.Morphological and immunohistochemical evidence suggesting human papillomavirus(HPV)involvement in oral squamous cell carcinogenesis[J].Int J Oral Surg,1983,12:418-424.
[11] VILLAGÓMEZ-ORTÍZ V J,PAZ-DELGADILLO D E,MARINO-MARTÍNEZ I,et al.[Prevalence of human papillomavirus infection in squamous cell carcinoma of the oral cavity,oropharynx and larynx] [J].Cir Cir,2016,84:363-368.
[12] MARTIN-GOMEZ L,FULP W J,SCHELL M J,et al.Oral gargle-tumor biopsy human papillomavirus(HPV)agreement and associated factors among oropharyngeal squamous cell carcinoma(OPSCC)cases[J].Oral Oncol,2019,92:85-91.
[13] MEHANNA H,BEECH T,NICHOLSON T,et al.Prevalence of human papillomavirus in oropharyngeal and nonoropharyngeal head and neck cancer-systematic review and meta-analysis of trends by time and region[J].Head Neck,2013,35:747-755.
[14] QUREISHI A,MAWBY T,FRASER L,et al.Current and future techniques for human papilloma virus(HPV)testing in oropharyngealsquamous cell carcinoma[J].Eur Arch Otorhinolaryngol,2017,274:2675-2683.
[15] QUREISHI A,ALI M,FRASER L,et al.Saliva testing for human papilloma virus in oropharyngeal squamous cell carcinoma:A diagnostic accuracy study[J].Clin Otolaryngol,2018,43:151-157.
[16] WEAVER A N,COOPER T S,WEI S,et al:DNA-PkCS expression in oropharyngeal squamous cell carcinoma:Correlations with human papillomavirus status and recurrence after transoral robotic surgery[J].Head Neck,2017,39:206-214.
[17] AMIN M B,EDGE S,GREENE F,et al.AJCC Cancer Staging Manual,8th edn.New York,NY:Springer (2017):120,128-130.
[18] SMITH R V,SCHIFF B A,GARG M,et al.The impact of transoral robotic surgery on the overall treatment of oropharyngeal cancer patients[J].Laryngoscope,2015,125:S1-S15.
[19] YEH D H,TAM S,FUNG K,et al.Transoral robotic surgery vs.radiotherapy for management of oropharyngeal squamous cell carcinoma-A systematic review of the literature[J].Eur J Surg Oncol,2015,41:1603-1614.
[20] MASCHIO F,LEJUSTE P,ILANKOVAN V,et al.Evolution in the management of oropharyngeal squamous cell carcinoma:systematic review of outcomes over the last 25 years[J].Br J Oral Maxillofac Surg,2019,57:101-115.
[21] MARTIN D,PASCAL J F,BAUDET J,et al.The submental island flap:a new dono site.Anatomy and clinical applications as a free or pedicled flap[J].Plast Reconstr Surg,1993,92:867-873.
[22] KOSHIMA I,HOSODA M,MORIGUCHI T,et al.A combined anterolateral thigh flap,anteromedial thigh flap,and vascularized iliac bone graft for a full-thickness defect of the mental region[J].Ann Plast Surg,1993,31:175-180.
[23] SHARMA A,MéNDEZ E,YUEH B,et al.Human papillomavirus-positive oral cavity and oropharyngeal cancer patients do not have better quality-of-life trajectories[J].Otolaryngol Head Neck Surg,2012,146:739-745.
计量
- 文章访问数: 660
- PDF下载数: 1239
- 施引文献: 0