吸烟与OSA严重程度的相关性研究

朱华明; 易红良; 关建; 许华俊; 刘素茹; 邹建银; 陈锐

doi:10.13201/j.issn.1001-1781.2019.09.016

吸烟与OSA严重程度的相关性研究

- 1 苏州大学附属第二医院呼吸内科(江苏苏州, 215004);
- 2 上海交通大学附属第六人民医院耳鼻咽喉头颈外科
基金项目:
国家自然基金项目(No:81770085)

苏州市临床重点病种诊疗技术专项项目(No:LCZX201604)

详细信息

通讯作者: 陈锐,E-mail:chenruigood@126.com

中图分类号: R563.8

收稿日期: 2019-01-15

Relationship between smoking and the severity of OSA

- 1 Department of Respiratory Medicine, Second Affiliated Hospital of Suzhou University, Suzhou, 215004, China;
- 2 Department of Otolaryngology Head and Neck Surgery, Shanghai Jiaotong University Affiliated Sixth People's Hospital

More Information

Corresponding author: CHEN Rui, E-mail: chenruigood@126.com

Received Date: 15 January 2019

摘要

摘要: 目的:探讨吸烟与OSA严重程度之间的关系。方法:719例患者纳入研究,均有打鼾、憋气、白天嗜睡等症状,符合纳入排除标准。均接受整夜PSG监测,监测指标包括AHI、SaO₂、氧减指数、微觉醒指数等;完成包括吸烟史在内的问卷调查、Epworth嗜睡量表填写;进行人体生理学数据(包括体重、身高、颈围、腰围、臀围等)测量。以AHI判定OSA的严重程度:<5为正常,5~15为轻度,>15~30为中度,>30为重度。以吸烟指数判定吸烟的严重程度:轻度吸烟为＜200,中度吸烟为200~400,重度吸烟为＞400。结果:719例患者中,非OSA者138例,OSA者581例;不吸烟者381例,吸烟者279例,已戒烟者59例。OSA组的吸烟率为41.5%,非OSA组为27.5%,OSA组的吸烟率显著高于非OSA组(P<0.01)。在剔除59例戒烟患者后,将剩余660例患者按吸烟情况分为不吸烟组、轻度吸烟组、中度吸烟组和重度吸烟组,每组再根据AHI分为非OSA组、轻度OSA组、中度OSA组和重度OSA组,结果发现吸烟严重程度与OSA严重程度间存在明显正相关(r=0.203,P<0.01);在矫正年龄、BMI和腰臀比等混杂因素后,两者之间仍有明显相关性(r=0.141,P<0.01);有序Logistic回归分析显示,在矫正年龄、BMI和腰臀比后,与不吸烟组相比,中度吸烟组和重度吸烟组发生OSA的风险分别增加1.72倍(OR=1.72,95%CI 1.08~2.75)和2.68倍(OR=2.68,95%CI 1.61~4.46)。结论:吸烟的严重程度与OSA严重程度之间存在正相关,吸烟程度重的患者发生OSA的风险增加,这种相关性独立于年龄及肥胖等危险因素。
- 睡眠呼吸暂停,阻塞性 /
- 吸烟 /
- 呼吸暂停低通气指数
Abstract: Objective: To explore the relationship between smoking and the severity of OSA.
- sleep apnea, obstructive /
- smoking /
- apnea-hypopnea index

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