谷胱甘肽对OSA合并代谢综合征患者氧化应激及瘦素、脂联素的影响

王袁; 张盼盼; 韩晓庆; 王玲; 王立民; 黄超; 王红阳

doi:10.13201/j.issn.1001-1781.2019.08.011

谷胱甘肽对OSA合并代谢综合征患者氧化应激及瘦素、脂联素的影响

- 华北理工大学附属医院(原华北煤炭医学院)呼吸科(河北唐山, 063000)
基金项目:
河北省卫生与计划生育委员会重点科技研究计划课题 (No:20150081)

河北省高等学校科学技术研究项目课题 (No:QN2016198)

河北省自然科学基金资助项目 (No:H2014209231)

详细信息

通讯作者: 王红阳,E-mail:tsmywhy@163.com

中图分类号: R563.8

收稿日期: 2019-02-10

Effects of glutathione on oxidative stress,leptin and adiponectin in patients with obstructive sleep apnea complicated with metabolic syndrome

- 1 Department of Otorhinolaryngology, Second Hospital of Hebei Medical University, Shijiazhuang, 050000, China;

More Information

Corresponding author: WANG Hongyang, E-mail: tsmywhy@163.com

Received Date: 10 February 2019

摘要

摘要: 目的:分析谷胱甘肽对OSA合并代谢综合征(MS)患者氧化应激状态与血清瘦素、脂联素(ADP)的影响。方法:依照纳入排除标准收集OSA合并MS患者159例作为A组,单纯OSA组不伴有MS患者159例作为B组,同期以159名体检者为对照组。3组人群在治疗前及谷胱甘肽治疗后分别检测氧化应激指标丙二醛(MDA)、超氧化物歧化酶(SOD)、瘦素及ADP的含量。结果:与对照组相比,A组和B组的MDA、瘦素含量明显高于对照组,SOD、ADP含量明显低于对照组,差异有统计学意义,以A组变化更为显著。A、B组患者治疗后SOD、ADP水平明显高于治疗前,MDA、瘦素水平明显低于治疗前,差异均有统计学意义,也以A组变化更为显著。结论:OSA合并MS患者伴有氧化应激,谷胱甘肽可有效提高此类患者机体抗氧化应激的能力,减轻氧化损伤,同时降低瘦素,提升ADP水平。
- 睡眠呼吸暂停 /
- 阻塞性 /
- 氧化应激 /
- 瘦素 /
- 脂联素 /
- 谷胱甘肽
Abstract: Objective: The aim of this study is to analyze the effects of glutathione on oxidative stress, leptin and adiponectin in patients with obstructive sleep apnea(OSA) complicated with metabolic syndrome. Method: One hundred and fifty-nine patients with OSA and MS were enrolled in the group A according to the exclusion criteria. One hundred and fifty-nine patients with MS group were not included in the OSA group, and 159 patients were included in the control group. Before and after treatment, the levels of serum malondialdehyde (MDA), superoxide dismutase (SOD), Leptin and ADP were respectively detected, and the clinical effects of the three groups were compared. Result: Compared with the control group, the contents of MDA and Leptin in the case A and B groups were significantly higher than that of the control group, and the contents of SOD and ADP were significantly lower than that of the control group, and the difference was statistically significant, especially in case group A. The level of SOD and ADP was significantly higher in the group after treatment than before treatment, and the level of MDA and Leptin was significantly lower than before treatment. The difference was statistically significant, especially in case group A, too. Conclusion: Patients with OSA and MS are associated with oxidative stress. Glutathione can effectively improve the body's ability to resist oxidative stress, reduce oxidative damage, reduce leptin, and increase ADP levels.
- sleep apnea hypopnea /
- obstructive /
- metabolic syndrome /
- oxidative stress /
- leptin /
- adiponectin

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