The association between serum bilirubin levels and hearing loss in the patients with bilateral sudden deafness
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摘要: 目的:探讨血清胆红素水平与双侧突发性聋(突聋)听力损失严重程度的相关性。方法:连续纳入113例双侧突聋患者,应用单因素和多因素线性回归模型探究血清胆红素水平与初始听力水平之间的关系。结果:相较于听力损失中度及以下者(≤70 dB HL),>70 dB HL的双侧突聋患者具有相对较低的血清总胆红素和间接胆红素水平,相对较高的白细胞计数、中性粒细胞、血小板、碱性磷酸酶和较差的最终听阈。在调整了可能的混杂因素后,只有血清间接胆红素水平与双侧突聋患者的初始听力损失呈显著负相关。每1 μmol/L血清间接胆红素水平的提升对应着初始听力损失降低1.1 dB(95%CI:-2.2,0.0)。结论:在正常或接近正常的范围内,较高的间接胆红素水平与双侧突聋患者较轻的初始听力损失程度显著相关,提示在正常或接近正常范围内的血清胆红素对听觉系统可能有益。Abstract: Objective: The aim of this study was to investigate the association between serum bilirubin levels and the severity of bilateral sudden sensorineural hearing loss (BSSHL). Method: A total of 113 patients with bilateral axillary sputum were enrolled, and the relationship between serum bilirubin levels and initial hearing levels was explored using a univariate and multivariate linear regression model. Result: Compared with the group with moderate and below hearing loss (≤70 dB HL), patients with severe profound HL(>70 dB HL) were more likely to have lower levels of total and indirect bilirubin level, magnesium and relative hearing gain, higher levels of final hearing, white blood counts, neutrophil, platelet and alkaline phosphatase. After adjusting for possible confounders, only serum indirect bilirubin levels were significantly negatively correlated with initial hearing loss in patients with bilateral axillary sputum. 1 μmol/L increase of IBIL was associated with 1.1 dB (95%CI: -2.2, 0.0) reduction in initial hearing loss. Conclusion: Within the normal or mildly elevated range, higher levels of IBIL are independently and significantly associated with less severe hearing loss in BSSHL. It suggested a beneficial effect of bilirubin on auditory system.
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