嗜酸粒细胞性中耳炎的临床诊治

张玉忠; 魏馨雨; 陈耔辰; 孙曼; 成颖; 高滢; 陈飞云; 胡娟; 许珉; 张青; 樊孟耘

doi:10.13201/j.issn.1001-1781.2019.02.016

嗜酸粒细胞性中耳炎的临床诊治

- 1. 西安交通大学第二附属医院耳鼻咽喉头颈外科(西安, 710004);
- 2. 西安交通大学第二附属医院神经内科;
- 3. 西安市儿童医院耳鼻咽喉科
基金项目:
国家自然基金资助项目 (No:81670945)

陕西省国际科技合作重点项目 (No:2017KW-048)

西安交通大学医学院第二附属医院人才培养专项基金[No:RC (GG) 201407]

西安交通大学第二附属医院新技术新疗法重点项目 (No:2016YL-018)

详细信息

通讯作者: 张青,E-mail:zhqent@163.com

中图分类号: R764.21

收稿日期: 2018-11-07

Clinical diagnosis and treatment of eosinophilic otitis media

- 1. Department of Otolaryngology Head and Neck Surgery, the Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710004, China;
- 2. Department of Neurology, the Second Affiliated Hospital of Xi'an Jiaotong University;
- 3. Department of Otorhinolaryngology, Xi'an Children's Hospital

More Information

Corresponding author: ZHANG Qing, E-mail: zhqent@163.com

Received Date: 07 November 2018

摘要

摘要: 目的:探讨嗜酸粒细胞性中耳炎(EOM)的临床表现和诊治经验。方法:回顾性分析3例EOM患者的病史、临床表现、相关辅助检查。结合文献讨论EOM临床特征、诊断和治疗。结果:3例EOM患者患耳临床特点可以归纳为:大量黄白色分泌物或息肉形成,耳痒症状明显;息肉活检示大量嗜酸粒细胞浸润;局部使用含有糖皮质激素的滴耳液治疗有效。结论:EOM是慢性中耳炎的新的疾病类型,其具有特征性临床表现,治疗上给予以糖皮质激素为主的综合性治疗。
- 嗜酸粒细胞 /
- 中耳炎 /
- 诊断 /
- 治疗
Abstract: Objective:Eosinophilic otitis media (EOM) is a rare, refractory otitis media.This article summarizes the clinical manifestations and diagnosis and treatment experience of EOM.Method:Retrospective analysis of 3cases of EOM patients with medical history, clinical manifestations, and related auxiliary examinations.Discuss the EOM clinical features, diagnosis and treatment in conjunction with the literature.Result:The clinical features of 3patients with EOM were summarized as:a large amount of yellowish white secretions or polyps formation, obvious itching symptoms;polyp biopsy showed a large amount of eosinophil infiltration;topical use of hormonecontaining ear drops treatment is effective.Conclusion:EOM is a new type of chronic otitis media.It has characteristic clinical manifestations, a comprehensive treatment based on glucocorticoids should be given.
- eosinophils /
- otitis media /
- diagnosis /
- therapy

HTML全文

参考文献(16)

[1]	LARA-SANCHEZ H, VALLEJO L A.Eosinophilic Otitis Media[J].N Engl J Med, 2017, 376:e10.
[2]	IINO Y, TOMIOKA-MATSUTANI S, MATSUBARA A, et al.Diagnostic criteria of eosinophilic otitis media, a newly recognized middle ear disease[J].Auris Nasus Larynx, 2011, 38:456-461.
[3]	KANAZAWA H, YOSHIDA N, IINO Y.New Insights into Eosinophilic Otitis Media[J].Curr Allergy Asthma Rep, 2015, 15:1-9.
[4]	IINO Y.Eosinophilic otitis media:a new middle ear disease entity[J].Curr Allergy Asthma Rep, 2008, 8:525-530.
[5]	IINO Y.Role of IgE in eosinophilic otitis media[J].Allergol Int, 2010, 59:233-238.
[6]	KUDO N, MATSUBARA A, NISHIZAWA H, et al.Immunohistological analysis of eotaxin and RANTES in the model animal of eosinophilic otitis media[J].Acta Otolaryngol, 2017, 137:476-481.
[7]	UEKI S, OHTA N, TAKEDA M, et al.Eosinophilic otitis media:the aftermath of eosinophil extracellular trap cell death[J].Curr Allergy Asthma Rep, 2017, 17:33-33.
[8]	OHTA N, KUBOTA T, TOMIOKA-MATSUTANI S, et al.ETosis-derived DNA trap production in middle ear effusion is a common feature of eosinophilic otitis media[J].Allergol Int, 2018, 67:414-416.
[9]	张玉忠, 陈耔辰, 徐勇, 等.嗜酸粒细胞性中耳炎的研究进展[J].中国医学文摘 (耳鼻咽喉科学), 2017, 32 (4):194-197.
[10]	杜雅丽, 段清川, 马芙蓉.嗜酸性中耳炎的研究现状[J].临床耳鼻咽喉头颈外科杂志, 2017, 31 (6):489-492.
[11]	KANAZAWA H, YOSHIDA N, YAMAMOTO H, et al.Risk factors associated with severity ofeosinophilic otitis media[J].Auris Nasus Larynx, 2014, 41:513-517.
[12]	张玉忠, 陈耔辰, 徐勇, 等.嗜酸粒细胞性中耳炎一例[J].中华耳鼻咽喉头颈外科杂志, 2017, 52 (9):707-709.
[13]	YOSHIHIKO E, YUKIKO I, MARIA M, et al.Proposal of a treatment strategy foreosinophilic otitis media based on middle ear condition[J].OtolNeurotol, 2018, 39:e671-e678.
[14]	IINO Y, HARA M, HASEGAWA M, et al.Clinical efficacy of anti-IgE therapy for eosinophilic otitis media[J].OtolNeurotol, 2012, 33:1218-1224.
[15]	IINO Y, TAKAHASHI E, IDA S, et al.Clinical efficacy of anti-IL-5 monoclonal antibody mepolizumab in the treatment of eosinophilic otitis media[J].Auris Nasus Larynx, 2018, S0385-8146 (18) 30432-2.
[16]	HAN Y E, KANG Y S, CHO Y, et al.Eosinophilic otitis media treated with anti-ige monoclonal antibodies and a bone conduction implant[J].J Int Adv Otol, 2018, 14:144-147.