预防性中央区淋巴结清扫对甲状腺微小乳头状癌患者预后影响的Meta分析

安祥; 余丹; 李兵

doi:10.13201/j.issn.1001-1781.2019.02.011

预防性中央区淋巴结清扫对甲状腺微小乳头状癌患者预后影响的Meta分析

- 重庆医科大学附属第一医院耳鼻咽喉头颈外科(重庆, 400016)

详细信息

通讯作者: 李兵,E-mail:1390658110@qq.com

中图分类号: R736.1

收稿日期: 2018-11-19

Meta-analysis of the influence of prophylactic central lymph node dissection on the prognosis of patients with thyroid micropapillary carcinoma

- Department of Otolaryngology Head and Neck Surgery, the First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China

More Information

Corresponding author: LI Bing, E-mail: 1390658110@qq.com

Received Date: 19 November 2018

摘要

摘要: 目的:系统评估预防性中央颈淋巴结清扫术(pCND)在甲状腺微小乳头状癌(PTMC)中的疗效与安全性。方法:计算机检索PubMed、EMbase、Web of Knowledge、CBM、万方和CNKI数据库,搜集在PTMC手术治疗中行pCND的对照试验和队列研究,检索时限均为从建库至2018年9月。对符合入选标准的4篇文献进行Meta分析,计算相对危险度。结果:本研究共纳入4项回顾性队列研究共1 169例患者,行pCND降低了局部复发的风险,未增加喉返神经的损伤以及永久性低钙血症的发生率。术后暂时性低钙血症在行pCND后更为常见。结论:与单独行甲状腺及肿瘤切除术相比,pCND可以减少局部复发率且不会增加永久并发症。
- 淋巴结清扫术 /
- 甲状腺肿瘤 /
- 复发 /
- 并发症
Abstract: Objective:To evaluate the efficacy and safety of prophylactic central neck dissection (pCND) in papillary thyroid microcarcinoma (PTMC).Method:The PubMed, EMbase, Web of Knowledge, CBM, Wanfang, and CNKI databases were searched, and controlled trials and cohort studies of central lymph node dissection for cervical cancer in PTMC surgery were collected.The search time was from the establishment of the library to September 2018.Meta-analysis was performed on 4articles that met the inclusion criteria to calculate the relative risk.Result:A total of 1 169cases were included in 4retrospective cohort studies.In addition to conventional thyroidectomy, pCND reduced the risk of local recurrence and did not increase the recurrent laryngeal nerve (RLN) injury (temporary or permanent), the incidence of permanent hypocalcemia.Postoperative temporary hypocalcemia is more common after surgery with pCND.Conclusion:Prophylactic central lymph node dissection reduces local recurrence rates without increasing long-term complications compared with thyroid and tumor resection alone.
- lymph node dissection /
- thyroid neoplasms /
- recurrence /
- surgical complications

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