慢性鼻窦炎伴鼻息肉患者过敏状态与嗅觉及鼻部症状的关系

刘琢扶; 卢涵宇; 冯仙; 王德辉; 李华斌; 赵卫东

doi:10.13201/j.issn.1001-1781.2019.02.006

慢性鼻窦炎伴鼻息肉患者过敏状态与嗅觉及鼻部症状的关系

- 复旦大学附属眼耳鼻喉科医院耳鼻咽喉科(上海, 200031)
基金项目:
国家自然科学基金资助项目 (No:81670908, 81500781)

详细信息

通讯作者: 赵卫东,E-mail:zhaowda@sina.com

中图分类号: R765.4

收稿日期: 2018-11-02

Olfaction and sinonasal symptoms in CRSwNP patients with or without atopy

- Department of Otolaryngology, Affiliated Eye, Ear, Nose and Throat Hospital, Fudan University, Shanghai, 200031, China

More Information

Corresponding author: ZHAO Weidong, E-mail: zhaowda@sina.com

Received Date: 02 November 2018

摘要

摘要: 目的:探讨伴或不伴过敏的慢性鼻窦炎伴鼻息肉(CRSwNP)患者嗅觉障碍与鼻部相关症状存在的差异。方法:连续收集288例拟行鼻内镜手术的CRSwNP患者的过敏原检查结果、嗅觉评分、鼻部相关症状及CT评分并进行分析。结果:288例CRSwNP患者中有71.3%的患者伴有嗅觉下降,34.5%的患者伴有嗅觉障碍。发现嗅觉障碍程度和鼻部症状(鼻塞和流涕)及CT评分有关(P<0.01),但是和患者的过敏状态无明显相关。多项逻辑回归分析显示鼻塞和CT评分是CRSwNP患者嗅觉障碍的危险因素(OR为1.293和1.349,P<0.01)。结论:过敏状态并不直接影响CRSwNP患者的嗅觉障碍,局部炎症的严重程度对嗅觉的影响较大,通过手术治疗可以改善患者的嗅觉功能,从而进一步改善患者的生活质量。
- 鼻窦炎 /
- 鼻息肉 /
- 嗅觉障碍 /
- 过敏 /
- CT评分
Abstract: Objective:Olfactory impairment is commonly observed in chronic rhinosinusitis with nasal polyps (CRSwNP) and has a significant impact on quality of life.However, the risk factors for olfactory impairment have not been fully understood, and whether atopy is predisposed to olfactory impairment in CRSwNP patients remains unclear.The present study aims to unveil differences in olfaction and sinonasal symptoms between CRSwNP with and without atopy by means of a hospital-based, cross-sectional survey.Method:In this study, 288 CRSwNP patients ready for sinus surgery were consecutively enrolled, and atopy, olfaction, sinonasal symptoms and CT scores were evaluated.Result:We found 71.3%of CRSwNP patients presented olfactory loss and 34.5%of them presented olfactory complaint in this cohort (In this study, olfactory impairment has been defined when VAS ≥ 1and olfactory dysfunction has been defined when VAS ≥ 5).The decreased olfactory function was associated with sinonasal symptoms (nasal congestion and rhino rhea) and total CT scores (P<0.01), but not with atopy.Multivariate logistic regression revealed that nasal congestion score and total CT score were risk factors for olfactory dysfunction (OR, 1.293and 1.349;P<0.01) in CRSwNP patients.Conclusion:Our findings indicate atopic condition may not directly cause olfactory impairment, and physician should pay attention to the surgical treatment for local disease severity to improve the olfactory function and quality of life.
- sinusitis /
- nasal polyps /
- olfactory dysfunction /
- atopy /
- CT scores

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