慢性鼻-鼻窦炎伴鼻息肉患者外周血和息肉组织中嗜酸粒细胞相关性分析

张志存; 李佩忠; 唐海燕; 程雷

doi:10.13201/j.issn.1001-1781.2019.01.004

慢性鼻-鼻窦炎伴鼻息肉患者外周血和息肉组织中嗜酸粒细胞相关性分析

- 1. 南京医科大学附属淮安第一医院耳鼻咽喉科江苏淮安, 223300);
- 2. 南京医科大学附属淮安第一医院病理科;
- 3. 南京医科大学第一附属医院江苏省人民医院耳鼻咽喉科;
- 4. 南京医科大学国际变态反应研究中心;
- 5. 江苏省临床医学研究院过敏与自身免疫性疾病研究所

详细信息

通讯作者: 程雷,E-mail:chenglei@jsph.org.cn

中图分类号: R765.4

收稿日期: 2018-11-01

Correlation analysis of eosinophils in peripheral blood and polyp tissues of patients with chronicrhinosinusitis with nasal polyps

- 1. Department of Otorhinolaryngology, the Affiliated Huaian No. 1 People's Hospital of Nanjing Medical University, Huai'an, 223300, China;
- 2. Department of Pathology, the Affiliated Huai'an No. 1 People's Hospital of Nanjing Medical University;
- 3. Department of Otorhinolaryngology, the First Affiliated Hospital of Nanjing Medical University, Jiangsu Provinal People's Hospital;
- 4. International Centre for Allergy Research, Nanjing Medical University;
- 5. The Institute of Allergy and Autoimmune Disease, Jiangsu Clinical Medicine Research Institution

More Information

Corresponding author: CHENG Lei, E-mail: chenglei@jsph.org.cn

Received Date: 01 November 2018

摘要

摘要: 目的:探讨慢性鼻-鼻窦炎伴鼻息肉(CRSwNP)患者外周血嗜酸粒细胞(Eos)与息肉组织Eos在不同时间段的相关性。方法:回顾性分析2008、2012及2016年在南京医科大学附属淮安第一医院行鼻内镜鼻窦手术的342例CRSwNP患者的资料,取鼻息肉标本行苏木精-伊红染色,对组织中每高倍视野Eos进行计数,并收集术前血常规检查中的Eos计数,研究3个时间段外周血Eos与息肉组织Eos之间的关系。结果:CRSwNP患者外周血Eos计数与息肉组织Eos计数在2008、2012及2016年均呈正相关(r=0.275、0.435、0.505,均P<0.05),3年中ROC曲线下面积值均>0.7。结论:CRSwNP患者的外周血Eos数量与息肉组织Eos浸润呈正相关的关系,尽管不同时间段的截断值有变化,外周血Eos可作为预判Eos浸润型CRSwNP的参考指标。
- 鼻窦炎 /
- 鼻息肉 /
- 嗜酸粒细胞
Abstract: Objective:To explore the correlation between peripheral blood eosinophils and tissue eosinophils in patients with chronic rhinosinusitis with nasal polyps (CRSwNP) in different periods.Method:This trial was a prospective study involved 342 patients with CRSwNP who were treated by endoscopic sinus surgery in the Huai'an First People's Hospital, Nanjing Medical University in 2008, 2012 and 2016.Nasal polyp resection specimens were stained by HE.Tissue eosinophils were counted per high-power field, and peripheral blood eosinophils were collected from blood routine examination before operation.The relationship between peripheral blood eosinophils and tissue eosinophils were evaluated.Result:The correlation between peripheral blood eosinophils and tissue eosinophils was positive in nasal polyps in 2008, 2012 and 2016 (r=0.275, 0.435, 0.505, respectively).AUC values were all greater than 0.7. Conclusion:There is a positive correlation between peripheral blood eosinophils and tissue eosinophils infiltration in patients with CRSwNP.Although the cut-off value is changing, peripheral blood eosinophils can be used as an indicator for predicting eosinophilic CRSwNP.
- sinusitis /
- nasal polyps /
- eosinophils

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