生物钟原理及其对变应性鼻炎的调控

张艳廷; 曹济民; 赵长青

doi:10.13201/j.issn.1001-1781.2019.01.001

生物钟原理及其对变应性鼻炎的调控

- 1. 山西医科大学第二医院耳鼻咽喉头颈外科(太原, 030001);
- 2. 山西医科大学生理学系细胞生理学教育部重点实验室
基金项目:
国家自然科学基金(No:81670914,No:81870707)

山西省回国留学人员重点科研资助项目(No:2014-重点3)

详细信息

通讯作者: 赵长青,E-mail:fahyj@126.com

中图分类号: R765.21

收稿日期: 2018-12-11

Principle of biological clock and its regulation on allergic rhinitis

More Information

Corresponding author: , E-mail: fahyj@126.com

Received Date: 11 December 2018

摘要

- 生物钟 /
- 鼻炎 /
- 变应性 /
- IgE /
- 肥大细胞
Abstract: Mast cell degranulation plays a central role in the pathogenesis of allergic rhinitis.Recent studies have shown that mast cell degranulation exhibits circadian rhythm, which may be related to the periodic expression of circadian clock gene in mast cell and to the association with this kind of circadian clock genes and FcεRI.This paper focused on the biological clock mechanism of mast cell degranulation and summarized the neuroendocrine mechanism of allergic rhinitis under the regulation of biological clock.
- circadian clocks /
- rhinitis /
- allergic /
- immunoglobulin E /
- mast cell

HTML全文

参考文献(43)

[1]	ARJONA A, SILVER A C, WALKER W E, et al.Immunity's fourth dimension:approaching the circadian-immune connection[J].Trends Immunol, 2012, 33:607-612.
[2]	CERMAKIAN N, LANGE T, GOLOMBEK D, et al.Crosstalk between the circadian clock circuitry and the immune system[J].Chronobiol Int, 2013, 30:870-888.
[3]	CURTIS A M, BELLET M M, SASSONE-CORSIP, et al.Circadian clock proteins and immunity[J].Immunity, 2014, 40:178-186.
[4]	MAN K, LOUDON A, CHAWLA A.Immunity around the clock[J].Science, 2016, 354:999-1003.
[5]	SCHEIERMANN C, GIBBS J, INCE L, et al.Clocking in to immunity[J].Nat Rev Immunol, 2018, 18:423-437.
[6]	TUREK F W.Circadian clocks:not your grandfather's clock[J].Science, 2016, 354:992-993.
[7]	MOHAWK J A, GREEN C B, TAKAHASHi J S.Central and peripheral circadian clocks in mammals[J].Annu Rev Neurosci, 2012, 35:445-462.
[8]	DIBNER C, SCHIBLER U, ALBRECHT U.The mammalian circadian timing system:organization and coordination of central and peripheral clocks[J].Annu Rev Physiol, 2010, 72:517-549.
[9]	TAKAHASHI J S, HONG H K, KO C H, et al.The genetics of mammalian circadian order and disorder:implications for physiology and disease[J].Nat Rev Genet, 2008, 9:764-775.
[10]	UKAI H, UEDA H R.Systems biology of mammalian circadian clocks[J].Annu Rev Physiol, 2010, 72:579-603.
[11]	KO C H, TAKAHASHI J S.Molecular components of the mammalian circadian clock[J].Hum Mol Genet, 2006, 15:R271-277.
[12]	PARTCH C L, GREEN C B, TAKAHASHI J S.Molecular architecture of the mammalian circadian clock[J].Trends Cell Biol, 2014, 24:90-99.
[13]	SPERBER P A.The allergist and the biological time clock[J].Ann Allergy, 1972, 30:642-644.
[14]	SMOLENSKY M H, LEMMER B, REINBERG AE.Chronobiology and chronotherapy of allergic rhinitis and bronchial asthma[J].Adv Drug Deliv Rev, 2007, 59:852-882.
[15]	GELFAND E W.Inflammatory mediators in allergic rhinitis[J].J Allergy Clin Immunol, 2004, 114:S135-S138.
[16]	AOYAGI M, WATANABE H, SEKINE K, et al.Circadian variation in nasal reactivity in children with allergic rhinitis:correlation with the activity of eosinophils and basophilic cells[J].Int Arch Allergy Immunol, 1999, 120:95-99.
[17]	HONMA A, YAMADA Y, NAKAMARU Y, et al.Glucocorticoids reset the nasal circadian clock in mice[J].Endocrinology, 2015, 156:4302-4311.
[18]	KELLY E A, HOUTMAN J J, JARJOUR N N.Inflammatory changes associated with circadian variation in pulmonary function in subjects with mild asthma[J].Clin Exp Allergy, 2004, 34:227-233.
[19]	SEERY J P, JANES S M, IND P W, et al.Circadian rhythm of cutaneous hypersensitivity reactions in nocturnal asthma[J].Ann Allergy Asthma Immunol, 1998, 80:329-332.
[20]	MAURER M, ORTONNE J P, ZUBERBIER T.Chronic urticaria:an internet survey of health behaviours, symptom patterns and treatment needs in European adult patients[J].Br J Dermatol, 2009, 160:633-641.
[21]	LEE R E, SMOLENSKY M H, LEACH C S, et al.Circadian rhythms in the cutaneous reactivity to histamine and selected antigens, including phase relationship to urinary cortisol excretion[J].Ann Allergy, 1977, 38:231-236.
[22]	FISHBEIN A B, VITATERNA O, HAUGH I M, et al.Nocturnal eczema:review of sleep and circadian rhythms in children with atopic dermatitis and future research directions[J].J Allergy Clin Immunol, 2015, 136:1170-1177.
[23]	CHANG Y S, CHIANG B L.Mechanism of sleep disturbance in children with atopic dermatitis and the role of the circadian rhythm and melatonin[J].Int JMol Sci, 2016, 17:462-465.
[24]	NAKAO A, NAKAMURA Y, SHIBATA S.The circadian clock functions as a potent regulator of allergic reaction[J].Allergy, 2015, 70:467-473.
[25]	NAKAMURA Y, NAKANO N, ISHIMARU K, et al.Circadian regulation of allergic reactions by the mast cell clock in mice[J].J Allergy Clin Immunol, 2014, 133:568-575.
[26]	赵长青.变应性鼻炎//田勇泉.主编.全国高等学校教材——耳鼻咽喉头颈外科学[M].8版.北京:人民卫生出版社, 2013:60-62.
[27]	中华耳鼻咽喉头颈外科杂志编辑委员会鼻科组, 中华医学会耳鼻咽喉头颈外科学分会鼻科组.变应性鼻炎诊断和治疗指南 (2015年, 天津)[J].中华耳鼻咽喉科头颈外科杂志, 2016, 51 (1):6-24.
[28]	BERNSTEIN J A, MOELLMAN J.Emerging concepts in the diagnosis and treatment of patients with undifferentiated angioedema[J].Int J Emerg Med, 2012, 5:39-42.
[29]	DUGAS-BREIT S, PRZYBILLA B, SCHOPF P, et al.Possible circadian variation of serum mast cell tryptase concentration[J].Allergy, 2005, 60:689-692.
[30]	FRIEDMAN B S, STEINBERG S C, MEGGS W J, et al.Analysis of plasma histamine levels in patients with mast cell disorders[J].Am J Med, 1989, 87:649-654.
[31]	ANDO N, NAKAMURA Y, ISHIMARU K, et al.Allergen-specific basophil reactivity exhibits daily variations in seasonalallergic rhinitis[J].Allergy, 2015, 70:319-322.
[32]	FIDAN V, ALP H H, GOZELER M, et al.Variance of melatonin and cortisol rhythm in patients with allergic rhinitis[J].Am J Otolaryngol, 2013, 34:416-419.
[33]	程冯丽, 祁雪萍, 赵长青, 等.内源性糖皮质激素对小鼠变应性鼻炎免疫反应的影响[J].中华耳鼻咽喉科杂志, 2018, 53 (10):757-764.
[34]	NAKAMURA Y, HARAMA D, SHIMOKAWA N.Circadian clock gene Period2 regulates a time-of-daydependent variation in cutaneous anaphylactic reaction[J].J Allergy Clin Immunol, 2011, 127:1038-1045.
[35]	WANG X, REECE S P, VAN SCOTT M R, et al.Acircadian clock in murine bone marrow-derived mast cells modulates IgE-dependent activation in vitro[J].Brain Behav Immun, 2010, 25:127-134.
[36]	BAUMANN A, GÖNNENWEIN S, BISCHOFF SC, et al.The circadian clock is functional in eosinophils and mast cells[J].Immunology, 2013, 140:465-474.
[37]	TERADA T, TAKAHASHI T, ARIKAWA H, et al.Analysis of the conformation and thermal stability of the high-affinity IgE Fc receptorβchain polymorphic proteins[J].Biosci Biotechnol Biochem, 2016, 4:1-6.
[38]	KRAFT S, RANA S, JOUVIN M H, et al.The role of the FcepsilonRI beta-chain in allergic diseases[J].Int Arch Allergy Immunol, 2004, 135:62-72.
[39]	HIRAOKA S, FURUMOTO Y, KOSEKI H, et al.Fc receptor beta subunit is required for full activation of mast cells through Fc receptor engagement[J].Int Immunol, 1999, 11:199-207.
[40]	DALLMANN R, BROWN S A, GACHON F.Chronopharmacology:new insights and therapeutic implications[J].Annu Rev Pharmacol Toxicol, 2014, 54:339-361.
[41]	DURRINGTON H J, FARROW S N, LOUDON AS, et al.The circadian clock and asthma[J].Thorax, 2014, 69:90-92.
[42]	PINCUS D J, HUMESTON T R, MARTIN R J.Further studies on the chronotherapy of asthma with inhaled steroids:the effect of dosage timing on drug efficacy[J].J Allergy Clin Immunol, 1997, 100:771-774.
[43]	SMOLENSKY M H, LEMMER B, REINBERG AE.Chronobiology and chronotherapy of allergic rhinitis and bronchial asthma[J].Adv Drug Deliv Rev, 2007, 59:852-882.