-
Abstract: Hearing loss caused by disorders throughout the cochlea or auditory pathway called sensorineural hearing loss.The etiology of sensorineural deafness is complex and diverse, and the sensory epithelial cell damage of the inner ear spiral is the main pathological change.MicroRNAs play a role in the regulation of gene expression by inhibiting or degrading the mRNA of target genes.More and more studies have shown that microRNA plays an important role in the development of sensorineural deafness.This article will review the process of microRNA involvement in the development of sensorineural hearing loss.
-
Key words:
- microRNA /
- hearing loss /
- sensorineural
-
-
[1] OLUSANYA B O, NEUMANN K J, SAUNDERS JE.The global burden of disabling hearing impairment:a call to action[J].Bull World Health Organ, 2014, 92:367-373.
[2] RAVIV D, DROR A A, AVRAHAM K B.Hearing loss:a common disorder caused by many rare alleles[J].Ann N Y Acad Sci, 2010, 1214:168-179.
[3] KENNESON A, VAN NAARDEN BRAUN K, BOYLE C.GJB2 (connexin 26) variants and nonsyndromic sensorineural hearing loss:a HuGE review[J].Genet Med, 2002, 4:258-274.
[4] 赵雪雷, 黄丽辉, 王雪瑶, 等.SLC26A4基因致聋突变患儿的基因型和听力学特点分析[J].临床耳鼻咽喉头颈外科杂志, 2018, 32 (11):836-840.
[5] MAHMOODIAN-SANI M R, MEHRI-GHAHFAR-ROKHI A.The potential of miR-183family expression in inner ear for regeneration, treatment, diagnosis and prognosis of hearing loss[J].J Otol, 2017, 12:55-61.
[6] LEWIS M A, QUINT E, GLAZIER A M, et al.An ENU-induced mutation of miR-96 associated with progressive hearing loss in mice[J].Nat Genet, 2009, 41:614-618.
[7] MENCIA A, MODAMIO-HøYBJøR S, REDSHAWN, et al.Mutations in the seed region of human miR-96are responsible for nonsyndromic progressivehearing loss[J].Nat Genet, 2009, 41:609-613.
[8] SOLDAG, ROBUSTO M, PRIMIGNANI P, et al.Anovel mutation within the MIR96 gene causes nonsyndromic inherited hearing loss in an Italianfamily by altering pre-miRNA processing[J].Hum Mol Genet, 2012, 21:577-585.
[9] HILDEBRAND M S, WITMER P D, XU S, et al.miRNA mutations are not a common cause of deafness[J].Am J Med Genet A, 2010, 152A:646-652.
[10] ZHANG Q, LIU H, MCGEE J, et al.Identifying microRNAs involved in degeneration of the organ of corti during age-related hearing loss[J].PLoS One, 2013, 8:e62786.
[11] XUE T, LI W, DING J Z, et al.miR-29boverexpression induces cochlear hair cell apoptosis through the regulation of SIRT1/PGC-1αsignaling:Implications for age-related hearing loss[J].International Journal Of Molecular Medicine, 2016, 38:1387-1394.
[12] XIONG H, PANG J, YANG H, et al.Activation of miR-34a/SIRT1/p53 signaling contributes to cochlear hair cell apoptosis:implications for age-related hearing loss[J].Neurobiol Aging, 2015, 36:1692-1701.
[13] PANG J, XIONG H, LIN P, et al.Activation of miR-34aimpairs autophagic flux and promotes cochlear cell death via repressingATG9A:implications for age-related hearing loss[J].Cell Death Dis, 2017, 8:e3079.
[14] YU L, TANG H, JIANG X H, et al.Involvement of calpain-I and microRNA34 in kanamycin-induced apoptosis of inner ear cells[J].Cell Biol Int, 2010, 34:1219-1225.
[15] LI Y, LI A, WU J, et al.MiR-182-5p protects inner ear hair cells from cisplatin-induced apoptosis by inhibiting FOXO3a[J].Cell Death Dis, 2016, 7:e2362.
[16] 张志远, 刘凯, 陈燕红, 等.miR-183家族在噪声性聋发生发展中的表达及研究[J].临床耳鼻咽喉头颈外科杂志, 2014, 28 (7):468-472.
[17] RUDNICKI A, AVRAHAM K B.microRNAs:the art of silencing in the ear[J].EMBO Mol Med, 2012, 4:849-859.
[18] MENDELL J T, OLSON E N.MicroRNAs in stress signaling and human disease[J].Cell, 2012, 148:1172-1187.
[19] PATEL M, CAI Q, DING D, et al.The miR-183/Taok1 target pair is implicated in cochlear responses to acoustic trauma[J].PLoS One, 2013, 8:e58471.
[20] RYAN A F, HARRIS J P, KEITHLEY E M.Immune-mediated hearing loss:basic mechanisms and options for therapy[J].Acta Otolaryngol Suppl, 2002, 548:38-43.
[21] CHAU J K, LIN J R, ATASHBAND S, et al.Systematic review of the evidence for the etiology of adult sudden sensorineural hearing loss[J].Laryngoscope, 2010, 120:1011-1121.
[22] HAN S Y, KIM S, SHIN D H, et al.The Expression of AGO2 and DGCR8 in Idiopathic Sudden Sensorineural Hearing Loss[J].Clin Exp Otorhinolaryngol, 2014, 7:269-274.
[23] KIM S, LEE J H, NAM S I.Dicer Is Down-regulated and Correlated with Drosha in Idiopathic Sudden Sensorineural Hearing Loss[J].J Korean Med Sci, 2015, 30:1183-1188.
[24] LI Q, PENG X, HUANG H, et al.RNA sequencing uncovers the key microRNAs potentially contributing to sudden sensorineuralhearing loss[J].Medicine (Baltimore), 2017, 96:e8837.
[25] TAN P X, DU S S, REN C, et al.MicroRNA-207enhances radiation-induced apoptosis by directly targeting Akt3 in cochlea haircells[J].Cell Death Dis, 2014, 5:e1433.
[26] RUDNICKI A, SHIVATZKI S, BEYER L A, et al.microRNA-224regulates Pentraxin 3, a component of the humoral arm of innate immunity, in inner ear inflammation[J].Hum Mol Genet, 2014, 23:3138-3146.
[27] PRASAD K N, BONDY S C.MicroRNAs in Hearing Disorders:Their Regulation by Oxidative Stress, Inflammation and Antioxidants[J].Front Cell Neurosci, 2017, 11:276-276.
[28] PRASAD K N.Oxidative stress and pro-inflammatory cytokines may act as one of the signals for regulating microRNAs expression in Alzheimer's disease[J].Mech Ageing Dev, 2017, 162:63-71.
[29] FAN Y, ZHANG Y, WU R, et al.miR-431is involved in regulating cochlear function by targeting Eya4[J].Biochim Biophys Acta, 2016, 1862:2119-2126.
[30] LI Y, PENG A, GE S, et al.miR-204suppresses cochlear spiral ganglion neuron survival in vitro by targeting TMPRSS3[J].Hear Res, 2014, 314:60-64.
[31] USHAKOV K, RUDNICKI A, AVRAHAM K B.MicroRNAs in sensorineural diseases of the ear[J].Front Mol Neurosci, 2013, 6:52-52.
[32] MAHMOUDIAN-SANI M R, MEHRI-GHAHFAR-ROKHI A, AHMADINEJAD F, et al.MicroRNAs:effective elements in ear-related diseases and hearing loss[J].Eur Arch Otorhinolaryngol, 2017, 274:2373-2380.
-
计量
- 文章访问数: 63
- PDF下载数: 43
- 施引文献: 0
下载: