丁苯酞对老年OSAHS患者氧化应激及认知功能的影响

张盼盼; 汪彦辉; 韩晓庆; 黄超; 戈艳蕾; 王袁; 赵雅宁; 王玲; 王金环; 王红阳

doi:10.13201/j.issn.1001-1781.2018.18.014

丁苯酞对老年OSAHS患者氧化应激及认知功能的影响

- 1. 华北理工大学附属医院呼吸科(河北唐山, 063000);
- 2. 华北理工大学临床医学院
基金项目:
河北省卫生与计划生育委员会重点科技研究计划课题（No：20150081）；河北省高等学校科学技术研究项目课题（No：QN2016198）；河北省自然科学基金资助项目（No：H2014209231）

详细信息

通讯作者: 王红阳,E-mail:tsmywhy@163.com

中图分类号: R563.8

收稿日期: 2018-06-28

Effect of butylphthalide on oxidative stress and cognitive function in old obstructive sleep apnea hypopnea syndrome patients

- 1. Department of Respiration of North China University of Science and Technology Affiliated Hospital, 063000, China;
- 2. Clinical Medicine College of North China University of Science and Technology

More Information

Corresponding author: WANG Hongyang, E-mail: tsmywhy@163.com

Received Date: 28 June 2018

摘要

摘要: 目的：探讨丁苯酞对老年阻塞性睡眠呼吸暂停低通气综合征（OSAHS）患者氧化应激及认知功能的影响。方法：选择90例经多导睡眠监测（PSG）确诊的中重度OSAHS合并认知功能损害的老年患者，根据随机数字表法随机分为无创呼吸机组、丁苯酞+无创呼吸机组及丁苯酞治疗组，每组30例。无创呼吸机组患者采取持续气道正压通气（CPAP）治疗3个月，丁苯酞+无创呼吸机组在CPAP基础上给予口服丁苯酞治疗3个月，丁苯酞治疗组采用单纯口服丁苯酞治疗3个月。采用蒙特利尔认知评估量表评估3组患者治疗前、后认知功能的变化，同时采用免疫酶联吸附法检测血清SOD和MDA的变化，并进行对比分析。结果：3组患者治疗前血清超氧化物歧化酶（SOD）和丙二醛（MDA）相比，差异无统计学意义（P>0.05）；与治疗前比较，3组患者治疗后血清SOD水平均升高，MDA水平均下降（P<0.05）。与无创呼吸机组治疗后比较，丁苯酞+无创呼吸机组患者治疗后血清SOD水平升高，MDA水平下降（P<0.05），而丁苯酞治疗组患者治疗后血清SOD水平下降，MDA水平升高（P<0.05），与丁苯酞治疗组治疗后比较，丁苯酞+无创呼吸机组患者治疗后血清SOD水平升高，MDA水平下降（P<0.05）；3组患者治疗前认知功能MoCA各项指标评分相比，差异无统计学意义（P>0.05）；3组患者治疗后认知功能MoCA各项指标评分均高于其治疗前水平，差异有统计学意义（P<0.05）。与无创呼吸机组治疗后比较，丁苯酞+无创呼吸机组患者治疗后认知功能MoCA各项指标评分升高，丁苯酞治疗组患者治疗后认知功能MoCA各项指标评分降低，与丁苯酞治疗组治疗后比较，丁苯酞联合无创呼吸机组患者治疗后认知功能MoCA各项指标评分升高（P<0.05）。结论：丁苯酞有助于提高老年OSAHS患者血清中抗氧化酶的活性，抑制氧自由基和脂质过氧化，在一定程度上改善患者的认知功能。
- 丁苯酞 /
- 阻塞性睡眠呼吸暂停低通气综合征 /
- 老年人 /
- 超氧化物歧化酶 /
- 丙二醛 /
- 认知功能
Abstract: Objective: To explore the effect of butylphthalide on oxidative stress and cognitive function in old obstructive sleep apnea hypopnea syndrome (OSAHS)patients.Method: A total of 90 old OSAHS patients with cognitive impairment were choosed with Polysomnography(PSG). By random number table method OSAHS patients were randomly divided into non-invasive ventilator group (n=30), butylphthalide with non-invasive ventilator group(n=30) and treatment group of butylphthalide(n=30). Non-invasive ventilator group was given continuous positive airway pressure treatment for three months, butylphthalide with non-invasive ventilator group accepted oral butylphthalide therapy and continuous positive airway pressure treatment for three months, treatment group of butylphthalide only accepted oral butylphthalide therapy for three months. Cognitive function of three groups wered observed by the Montreal cognitive assessment scale (MoCA) before and after treatment, at the same time, the changes of serum superoxide dismutase(SOD) and malondialdehyde(MDA) were detected by immunoenzyme-linked adsorption.Result: The differences of serum SOD and MDA before treatment among the three groups were not statistically significant (P>0.05). Compared with before treatment, the level of serum SOD increased and the level of MDA decreased in the three groups (P<0.05). Compared with non-invasive ventilator group after treatment,the level of SOD increased and the level of MDA decreased in butylphthalide with non-invasive ventilator group (P<0.05), the level of SOD decreased and the level of MDA increased in treatment group of butylphthalide (P<0.05). Compared with treatment group of butylphthalide after treatment, the level of SOD increased and the level of MDA decreased in butylphthalide with non-invasive ventilator group (P<0.05); The scores of MoCA on cognitive function before treatment in the three groups was not statistically significant (P>0.05). After treatment the scores of MoCA on cognitive function in the three groups were higher than those before treatment (P<0.05). Compared with non-invasive ventilator group after treatment, the scores of MoCA increased in butylphthalide with non-invasive ventilator group (P<0.05),the the scores of MoCA decreased in treatment group of butylphthalide (P<0.05). Compared with treatment group of butylphthalide after treatment, the scores of MoCA increased in butylphthalide with non-invasive ventilator group (P<0.05).Conclution: Butylphthalide can improve the activity of antioxidant enzymes in the serum of old patients with OSAHS, inhibit the oxygen free radical and lipid peroxidation and to a certain extent improve the cognitive function.
- butylphthalide /
- OSAHS /
- aged /
- SOD /
- MDA /
- Cognition

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