102例突发性聋患者近期与远期疗效及预后的影响因素比较

朱晓月; 王巍; 陈鱼; 王悦; 陈晨; 林鹏

doi:10.13201/j.issn.1001-1781.2018.17.008

102例突发性聋患者近期与远期疗效及预后的影响因素比较

- 1. 天津医科大学一中心临床学院(天津, 300192);
- 2. 天津市第一中心医院耳鼻咽喉头颈外科天津市耳鼻喉科研究所
基金项目:
天津市应用基础与前沿技术研究计划（No：15JCYBJC27500）

详细信息

通讯作者: 林鹏,E-mail:linpengf@sina.com

中图分类号: R764.43

收稿日期: 2018-05-12

Comparison of the short-term and long-term curative effect and prognosis of 102 patients with sudden deafness

- 1. The First Center Clinical College, Tianjin Medical University, Tianjin, 300192, China;
- 2. Tianjin Institute of Otolaryngology, Department of Otolaryngology Head and Neck Surgery, the First Central Hospital of Tianjin

More Information

Corresponding author: LIN Peng, E-mail: linpengf@sina.com

Received Date: 12 May 2018

摘要

摘要: 目的：比较102例突发性聋（突聋）患者近期与远期疗效及预后的影响因素。方法：回顾性分析2012-2014年就诊的102例突聋患者的临床资料，对患者在治疗2周后和出院后3~5年分别复测纯音听阈，比较近期与远期疗效及预后的影响因素。结果：102例突聋患者近期总有效率为56.86%，远期总有效率为69.61%，在影响因素相同的情况下，远期总有效率大于近期总有效率，差异有统计学意义（均P<0.05）。进一步分析突聋的预后影响因素发现，听力曲线类型、血流变、血脂（TC、LDL、HDL）、年龄为突聋近期与远期相同的预后影响因素，不同听力曲线类型、血流变正常组与异常组、血脂正常组与异常组，不同年龄段组，各组间疗效结果比较差异有统计学意义（均P<0.05）。而近期与远期的预后影响因素是有区别的，近期疗效与血糖、TG有关，其中血糖正常组与异常组、TG正常组与异常组之间疗效比较差异有统计学意义（均P<0.05）。结论：突聋的远期疗效优于近期疗效。
- 聋,突发性 /
- 预后 /
- 因素分析
Abstract: Objective: To compare the short-term and long-term curative effect and prognostic factors of 102 patients with sudden deafness. Method: The clinical data of 102 patients with sudden deafness from 2012 to 2014 were analyzed retrospectively. Pure tone hearing thresholds were measured in patients with sudden deafness for 2 weeks after treatment and 3 to 5 years after discharge, in order to evaluate the short-term and long-term effects, and related prognostic factors were also compared. Result: The short-term total effective rate of 102 patients with sudden deafness was 56.86%, and the long-term total effective rate was 69.61%. Under the same influence factors(female group, TG abnormal group, LDL abnormal group, HDL abnormality, blood rheology abnormality), the long-term total effective rate was greater than the short-term total effective rate(P<0.05), the difference was statistically significant. Further analysis of the influencing factors of the prognosis of sudden deafness found that audiogram shapes, blood rheology and blood lipid(TC, LDL, HDL), age, were the same prognostic factors of sudden deafness. Different audiogram shapes, normal and abnormal hemorheology group, normal blood lipid group and abnormal group, the curative effect of different age groups, the difference which the results of each group were compared was significant(P<0.05). However, there were differences between short-term and long-term prognostic factors. The short-term prognostic factors were also related to blood glucose and TG, The difference between normal blood glucose group and abnormal was significant(P<0.05). The difference between the normal TG group and the abnormal group was compared, the difference was significant(P<0.05). Conclusion: The long-term curative effect of sudden deafness was better than that of the short-term.
- hearing loss, sudden /
- prognosis /
- factor analysis

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参考文献(18)

[1]	中华耳鼻咽喉头颈外科杂志编辑委员会, 中华医学会耳鼻咽喉头颈外科学分会.突发性聋的诊断和治疗指南(2015)[J].中华耳鼻咽喉头颈外科杂志, 2015, 50(6):443-447.
[2]	CEYLAN A, CELENK F, KEMALO LU Y K, et al.Impact of prognostic factors on recovery from sudden hearingloss[J].Laryngol Otol, 2007, 121:1035-1040.
[3]	於娟娟.特发性突聋综合治疗的远期疗效及相关因素分析[D].广州:中山大学硕士学位论文, 2009.
[4]	BYL F M.Sudden hearing loss:eight years' experience and suggested prognostic table[J].Laryngoscope, 1984, 94:647-661.
[5]	PSIFIDIS A D, PSILLAS G K, DANIILIDIS J C.Sudden sensorineural hearing loss:long-term follow-up results[J].Otolaryngol Head Neck Surg, 2006, 134:809-815.
[6]	RYU I Y, PARK S H, PARK E B, et al.Factors prognostic of season-associated sudden sensorineural hearing loss:a retrospective observational study[J].J Audiol Otol, 2017, 21:44-48.
[7]	BULGURCU S, SAHIN B, AKGU G, et al.The effects of prognostic factors in idiopathic sudden hearing loss[J].Int Arch Otorhinolaryngol, 2018, 22:33-37.
[8]	中华耳鼻咽喉头颈外科杂志编辑委员会, 中华医学会耳鼻咽喉头颈外科分会.突发性聋诊断和治疗指南(2005年, 济南)[J].中华耳鼻咽喉头颈外科杂志, 2006, 41(8):569-569.
[9]	YEO S W, LEE D H, JUN B C, et al.Hearing outcome of suddensensor ineural hearing loss:long-term followup[J].Otolaryngol Head Neck Surg, 2007, 136:221-224.
[10]	鲁媛媛, 童步升, 杨见明, 等.突发性聋与微循环障碍关系的临床研究[J].中华耳科学杂志, 2007, 5(1):45-48.
[11]	HILDESHEIMER M, BLOCH F, MUNCHNIK C, et al.Blood viscosity and sudden sensorineural hearing loss[J].Arch Otolaryngol Head Neck Surg, 1990, 116:820-823.
[12]	王卫国, 许荣, 陆荣忠.突发性聋伴高脂血症患者降脂干预的临床研究[J].中华耳鼻咽喉科杂志, 2003, 38(5):336-339.
[13]	KOJIMA Y, ITO S, FURUYA N.Hearing improvement after therapy for hyperlipidemia in patients with chronic-phase sudden deafness[J].Ann Otol Rhinol Laryngol, 2001, 110:105-108.
[14]	JECMENICA J, BAJEC-OPANCINA A.Sudden hearing loss in children[J]Clin Pediatr (Phila), 2014, 53:874-878.
[15]	王英歌, 张榕, 许元腾等.不同年龄及不同类型突发性耳聋患者近期疗效观察[J].中华耳科学杂志, 2012, 10(3):364-367.
[16]	王共明, 王春华.心理干预对单耳突发性聋疗效影响的相关性研究[J].中国医药导报, 2010, 7(1):49-50.
[17]	RYU O H, CHOI M G, PARK C H, et al.Hyperglycemia as a potential prognostic factor of idiopathic sudden sensorineural hearing loss[J].Otolaryngol Head Neck Surg, 2014, 50:853-858.
[18]	FUKUI M, KITAGAWA Y, NAKAMURA N, et al.Idiopathic sudden hearing loss in patients with type 2diabetes[J].Diabetes Res Clin Pract, 2004, 63:205-211.