Establishment and preliminary application of a laryngomalacia larynx three-dimension model
-
摘要: 目的：基于CT图像及已知的喉腔结构材料参数构建婴幼儿喉软化症喉腔有限元模型，探索该模型在喉软化症严重程度评估中的应用价值。方法：用MIMICS软件对CT扫描得到的Dicom图像进行处理，以材料灰度阈值区分不同的组织结构，采用可视化处理进行三维模型重建。用Hyermesh软件进行有限元网格划分。利用Abaqus软件，赋予模型喉腔结构材料参数并进行力学分析，得到其von Mises应力分布状况。结果：本研究建立了能够反映婴幼儿喉软化症喉腔形态特征的有限元模型。在模型上加载应力后发现，研究对象的喉软化症越严重其峰值von Mises应力越大。结论：该模型形态逼真，可用于后续研究。在模型上施加应力，分析模型峰值von Mises应力值可能可用于喉软化症严重程度的评估。Abstract: Objective: To establish and preliminarily apply a laryngomalacia larynx three-dimension finite element model.Method: The MIMCS software was employed to deal with the Dicom images of larynx CT scan by means of distinguishing material gray threshold of different tissues. 3D visualization model of larynx was also built by this software. Hyermesh software was used to handle the grid layout of larynx finite element model. Laryngeal structure parameter were added, and laryngeal mechanical analysis were carried out by Abaqus software in order to get von Mises stress. Result: A 3D model,which finely represent the morphological characteristics of laryngomalacia larynx was built using the finite element technology. Peak von Mises stress was observed to be higher in more severe laryngomalacia case. Conclusion: The 3D finite element model of the laryngomalacia larynx provides the foundation for further study.Peak von Mises stress may be a useful indicator of laryngomalacia severity assessment.
-
Key words:
- pediatric larynx /
- laryngomalacia /
- three-dimensional finite element /
- biomechanics
-
-
[1] DANIEL S J.The upper airway:congenital malformations[J].Paediatr Respir Rev, 2006, 7Suppl 1:S260-263.
[2] THOMPSON D M.Abnormal sensorimotor integrative function of the larynx in congenital laryngomalacia:a new theory of etiology[J].Laryngoscope, 2007, 117(6Pt 2Suppl 114):1-33.
[3] OLNEY D R, GREINWALD J J, SMITH R J, et al.Laryngomalacia and its treatment[J].Laryngoscope, 1999, 109:1770-1775.
[4] MANNING S C, INGLIS A F, MOUZAKES J, et al.Laryngeal anatomic differences in pediatric patients with severe laryngomalacia[J].Arch Otolaryngol Head Neck Surg, 2005, 131:340-343.
[5] LANE R W, WEIDER D J, STEINEM C, et al.Laryngomalacia.A review and case report of surgical treatment with resolution of pectus excavatum[J].Arch Otolaryngol, 1984, 110:546-551.
[6] WALNER D L, NEUMANN D B, HAMMING K K, et al.Supraglottoplasty in Infants:A Staged Approach[J].Ann Otol Rhinol Laryngol, 2015, 124:803-807.
[7] GARRITANO F G, CARR M M.Characteristics of patients undergoing supraglottoplasty for laryngomalacia.[J].Int J Pediatr Otorhinolaryngol, 2014, 78:1095-1100.
[8] VAN DER HEIJDEN M, DIKKERS F G, HALMOS G B.Treatment outcome of supraglottoplasty vs.wait-and-see policy in patients with laryngomalacia[J].Eur Arch Otorhinolaryngol, 2016, 273:1507-1513.
[9] 徐宏鸣, 顾美珍, 陈芳, 等.小儿喉腔三维有限元模型构建的方法及意义[J].山东大学耳鼻喉眼学报, 2018, 32(1):1-4.
[10] XU C, BRENNICK M J, DOUGHERTY L, et al.Modeling upper airway collapse by a finite element model with regional tissue properties[J].Med Eng Phys, 2009, 31:1343-1348.
[11] ZHANG Y, SHI T.The research of laryngeal joints to reconstruction and modeling[J].Biomed Mater Eng, 2014, 24:2627-2634.
[12] 许慧祥, 安云强, 胡歌, 等.扁桃体切除后伤口缝合方式对睡眠呼吸暂停患者咽腔结构影响的有限元方法研究[J].北京生物医学工程, 2017, 36(2):111-117.
[13] 李秋平, 胡艳群, 赵宏, 等.双管鼻塞式CPAP在早产儿肺透明膜病和新生儿呼吸衰竭中应用[J].临床儿科杂志, 2006, 24(11):887-889.
[14] KUSAK B, CICHOCKA-JAROSZ E, JEDYNAKWASOWICZ U, et al.Types of laryngomalacia in children:interrelationship between clinical course and comorbid conditions[J].Eur Arch Otorhinolaryngol, 2017, 274:1577-1583.
[15] 张亚敏, 王智楠, 夏忠芳.儿童喉软化症的研究进展[J].临床耳鼻咽喉头颈外科杂志, 2017, 31(2):162-166.
[16] PU S, XU H, LI X.Supraglottoplasty in neonates and infants:A radiofrequency ablation approach[J].Medicine (Baltimore), 2018, 97:e9850.
-
计量
- 文章访问数: 79
- PDF下载数: 41
- 施引文献: 0
下载: