磁共振弥散张量成像评价特发性失嗅脑白质微细结构损害的研究

姚淋尹; 郭怡辰; 占小俊; 孙智甫; 李瑛; 魏永祥

doi:10.13201/j.issn.1001-1781.2018.06.009

磁共振弥散张量成像评价特发性失嗅脑白质微细结构损害的研究

- 1. 首都医科大学附属北京安贞医院耳鼻咽喉头颈外科(北京, 100029);
- 2. 首都医科大学附属北京安贞医院医学影像科
基金项目:
“十三五”国家重点研发项目(No:2016YFC0800700)

国家自然科学基金(No:81670903)

首都医科大学附属北京安贞医院院长基金(No:2016Z02)

详细信息

通讯作者: 魏永祥,E-mail:wei.yongxiang@hotmail.com

中图分类号: R765.6

收稿日期: 2018-01-13

Preliminary study of DTI on cerebral white matter micro-structure of patients with idiopathic olfactory loss

- 1. Department of Otorhinolaryngology Head and Neck Surgery, Beijing Anzhen Hospital, Capital Medical University, Beijing, 100029, China;
- 2. Department of Radiology, Beijing Anzhen Hospital, Capital Medical University

More Information

Corresponding author: WEI Yongxiang, E-mail: wei.yongxiang@hotmail.com

Received Date: 13 January 2018

摘要

摘要: 目的:应用磁共振弥散张量成像(DTI)技术研究特发性失嗅患者脑白质微细结构的改变。方法:对16例特发性失嗅患者(患者组)与16例年龄、性别相匹配的健康志愿者(对照组)进行Sniffin'Stick嗅觉功能测试及脑DTI检查。在DTI生成的各向异性分数(FA)参数图上选择双侧梨状皮层、眶额皮层、海马、岛叶邻近白质和内囊为感兴趣区(ROI),计算每个ROI的FA值。采用独立样本t检验比较患者组和对照组间ROI的FA值差异,并与MMSE评分进行相关性分析。结果:患者组双侧梨状皮层、眶额皮层、海马及岛叶邻近白质FA值低于对照组(P<0.05),而双侧内囊FA值两组间比较差异无统计学意义(P>0.05)。结论:特发性失嗅患者存在嗅觉皮层邻近脑白质微细结构的损害,对于特发性失嗅的发病机制及早期干预具有重要的意义。
- 特发性失嗅 /
- 白质 /
- 微细结构 /
- 弥散张量成像
Abstract: Objective:To investigate the cerebral white matter micro-structure in patients with idiopathic olfactory loss using diffusion tensor imaging (DTI).Method:Sixteen patients with idiopathic olfactory loss and sixteen normal subjects matched by age and sex were recruited in this study. Sniffin'Stick olfactory test was performed to evaluate the olfactory function of all subjects. We acquired diffusion tensor images with an echo planar imaging (EPI) sequence from all subject on a 3T scanner. The fractional anisotropy (FA) images were performed using DTI-studio, and bilateral Piriform cortex, Orbitofrontal cortex, Hippocampus and Insula cortex adjacent white matter and Capsula interna were delineated as the region of interesting (ROI), the FA for each ROI was calculated. Independent sample t test analysis was used to compare the FA value of all ROIs between the controls and patients. In addition, correlation analysis between FA value and MMSE score in patients were conducted.Result:Compared with the controls, patients showed significantly decreased FA value in the adjacent white matter of bilateral Piriform cortex, Orbitofrontal cortex, Hippocampus and Insula cortex (P<0.05). There is no significant difference of FA value in bilateral Capsula interna between two groups (P>0.05).Conclusion:The patients with idiopathic olfactory loss show the damage of white matter micro-structure in the olfactory center, which could be important for the pathogenesis study and early intervention of idiopathic olfactory loss.
- idiopathic olfactory loss /
- white matter /
- micro-structure /
- diffusion tensor imaging

HTML全文

参考文献(12)

[1]	HAEHNER A, HUMMEL T, HUMMEL C, et al.Olfactory loss may be a first sign of idiopathic Parkinson's disease[J].Mov Disord, 2007, 22:839-842.
[2]	MAKOWSKA I, KIOSZEWSKA I, GRABOWSKA A, et al.Olfactory deficits in normal aging and Alzheimer's disease in the polish elderly population[J].Arch Clin Neuropsychol, 2011, 26:270-279.
[3]	YAO L, PINTO J M, YI X, et al.Gray matter volume reduction of olfactory cortices in patients with idiopathic olfactory loss[J].Chem Senses, 2014, 39:755-760.
[4]	郭怡辰, 姚淋尹, 魏永祥.糖皮质激素及银杏叶提取物治疗上呼吸道感染后嗅觉障碍临床效果观察[J].临床耳鼻咽喉头颈外科杂志, 2017, 31 (20):1585-1592.
[5]	彭璐, 余水莲, 景艳, 等.老年人中枢听觉系统的弥散张量成像研究[J].临床耳鼻咽喉头颈外科杂志, 2016, 30 (8):637-640.
[6]	NENADIC I, GLLMAR D, DIETZEK M, et al.Brain structure in narcissistic personality disorder:a VBM and DTI pilot study[J].Psychiatry Res, 2015, 23:184-186.
[7]	GEORGIOPOULOS C, WARNTJES M, DIZDAR N.et al.Olfactory impairment in Parkinson's disease studied with diffusion tensor and magnetization transfer imaging[J].J Parkinsons Dis, 2017, 7:301-311.
[8]	CHEN G, WEI Y, MIAO X, et al.Clinical features of olfactory disorders in patients seeking medical consultation[J].Med Sci Monit, 2013, 19:444-450.
[9]	ROMBAUX P, POTIER H, MARKESSIS E, et al.Olfactory bulb volume and depth of olfactory sulcus in patients with idiopathic olfactory loss[J].Eur Arch Otorhinolaryngol, 2010, 267:1551-1556.
[10]	GRAVES A B, BOWEN J D, RAJARAM L, et al.Impaired olfaction as a marker for cognitive decline:interaction with apolipoprotein E epsilon4status[J].Neurology, 1999, 53:1480-1487.
[11]	MORGAN C D, MURPHY C.Olfactory event-related potentials in Alzheimer's disease[J].J Int Neuropsychol Soc, 2002, 8:753-763.
[12]	WOODWARD M R, DWYER M G, BERQSLAND N, et al.Olfactory identification deficit predicts white matter tract impairment in Alzheimer's disease[J].Psychiatry Res, 2017, 266:90-95.