中-重度变应性鼻炎患者血清25(OH)D水平的相关临床研究

檀静怡; 刘涛; 张丽霞

doi:10.13201/j.issn.1001-1781.2018.03.015

中-重度变应性鼻炎患者血清25(OH)D水平的相关临床研究

- 1. 山西医科大学第一临床医学院(太原, 030000);
- 2. 山西医科大学第一附属医院耳鼻咽喉头颈外科

详细信息

通讯作者: 刘涛,E-mail:sylt2009@126.com

中图分类号: R765.21

收稿日期: 2017-11-28

Clinical study on serum 25(OH)D level in patients with moderate to severe allergic rhinitis

- 1. First Clinical Medicine School of Shanxi Medical University, Taiyuan, 030000, China;
- 2. Department of Otolaryngology Head and Neck Surgery, First Hospital of Shanxi Medical University

More Information

Corresponding author: LIU Tao, E-mail: sylt2009@126.com

Received Date: 28 November 2017

摘要

摘要: 目的：通过检测中-重度变应性鼻炎（AR）患者血清25（OH）D水平，初步探索维生素D对AR的作用机制，为AR的防治提供佐证。方法：以80例中-重度AR患者及65例健康成人为研究对象，采用酶联免疫吸附试验检测血清25（OH）D水平，并分析中-重度AR患者8种常见血清变应原的血清25（OH）D水平。结果：AR组血清25（OH）D水平为（29.4±4.7）ng/ml，对照组为（30.9±5.9）ng/ml，差异无统计学意义（P>0.05）。AR组血清维生素D缺乏所占百分比为36%，对照组为7%，差异有统计学意义（P<0.05）。在8种常见血清变应原中，对豚草、户尘螨和虾过敏的AR患者，维生素D缺乏和不足所占比例高于对照组，差异有统计学意义（P<0.05）。结论：维生素D缺乏与中-重度AR患者可能存在关联，维生素D对AR的发病进程可能有潜在的有益影响。
- 鼻炎,变应性 /
- 25(OH)D /
- 变应原 /
- 维生素D
Abstract: Objective: Through the detection of the serum 25 (OH) D level of patients with moderate to severe allergic rhinitis (AR), we preliminarily explored the mechanism of vitamin D on AR and provided evidence for the control of AR.Method: Eighty cases of moderate to severe AR and 65 healthy adults were selected as the subjects. The level of 25 (OH) D was detected by enzyme-linked immunosorbent assay (ELISA), and the serum 25 (OH) D level of eight common serum allergens in patients with moderate to severe AR was analyzed.Result: The level of serum 25 (OH) D of AR group was (29.4±4.7)ng/ml, and the serum level of 25 (OH) D in the control group was (30.9±5.9)ng/ml, no significant difference (P>0.05). The percentage of serum vitamin D deficiency in AR group was 36%, and the control group was 7%, and the difference was statistically significant (P<0.05). Among eight common serum allergens, the AR patients who were allergic to ragweed, household dust mites and shrimps, the percentage of vitamin D deficiency and insufficient was higher than that of the control group, the difference was statistically significant (P<0.05).Conclusion: Vitamin D deficiency may be associated with moderate to severe AR patients, and vitamin D may have potential beneficial effects on the progression of AR.
- rhinitis, allergic /
- 25(OH)D /
- allergen /
- vitamin D

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