Th1/Th2细胞失衡模式在分泌性中耳炎发病机制中的作用

李志辉; 符秋养; 李泽泳; 王克雄; 徐永城; 薛进平

doi:10.13201/j.issn.1001-1781.2018.03.012

Th1/Th2细胞失衡模式在分泌性中耳炎发病机制中的作用

- 1. 佛山市三水区人民医院耳鼻咽喉科(广东佛山, 528100);
- 2. 广东省第二人民医院耳鼻咽喉头颈外科;
- 3. 广东省第二人民医院生物实验中心
基金项目:
广东省医学科研基金资助（No：A2015074）

详细信息

通讯作者: 李志辉,E-mail:lzh9296@163.com

中图分类号: R764.23

收稿日期: 2017-12-17

The role of Th1/Th2 cells imbalance in the pathogenesis of secretory otitis media

- 1. Department of Otolaryngology, Sanshui District People's Hospital, Foshan, 528100, China;
- 2. Department of Otorhinolaryngology Head and Neck Surgery, Second People's Hospital of Guangdong;
- 3. Department of Biology Experiment Center, Second People's Hospital of Guangdong

More Information

Corresponding author: LI Zhihui, E-mail: lzh9296@163.com

Received Date: 17 December 2017

摘要

摘要: 目的：探讨Th1/Th2细胞失衡模式在分泌性中耳炎（SOM）发病机制中的作用。方法：选取SOM患者90例作为观察组，观察组根据病程长短分为急性组和慢性组；另外选取同期进行健康体检的志愿者90例作为对照组。比较2组患者外周血中Th1型细胞因子干扰素γ（IFN-γ）、Th2型细胞因子白细胞介素4（IL-4）及IFN-γ/IL-4的水平，比较急、慢性SOM患者外周血中IFN-γ、IL-4、IFN-γ/IL-4的水平，比较观察组患者的中耳积液与其外周血中IFN-γ、IL-4、IFN-γ/IL-4的水平。结果：观察组患者外周血中IFN-γ、IL-4、IFN-γ/IL-4的水平均高于对照组（P<0.05）；慢性组患者外周血中IFN-γ、IL-4、IFN-γ/IL-4的水平均高于急性组（P<0.05）；观察组患者外周血的IL-4、IFN-γ/IL-4水平与其中耳积液的IL-4、IFN-γ/IL-4水平相比差异均无统计学意义（P>0.05）；但其外周血的IFN-γ水平低于其中耳积液的IFN-γ水平（P<0.05）。结论：SOM患者外周血和中耳积液中IFN-γ、IL-4水平与疾病的发生发展有一定的关系，Th1/Th2的失衡可能是SOM的危险因素。
- 中耳炎,分泌性 /
- Th1/Th2细胞失衡模式 /
- 干扰素γ /
- 白细胞介素4 /
- 外周血 /
- 中耳积液
Abstract: Objective: The aim of this study is to explore the role of Th1/Th2 cells imbalance in the pathogenesis of secretory otitis media.Method: Ninety secretory otitis media patients were enrolled in observation group. According to medical history, they were divided into acute and chronic group. In addition, 90 healthy volunteers during the same period were selected as the control group. The levels of Th1-type cytokines IFN-γ, Th2-type cytokines interleukin-4 (IL-4) and IFN-γ/IL-4 in peripheral blood were compared between observation group and control group. Compare with acute and chronic secretory otitis media patients IFN-γ, IL-4, IFN-γ/IL-4 levels as well as the compare with middle ear effusion and peripheral blood sIFN-γ, IL-4, IFN-γ/IL-4 levels in observation group.Result: The level of IFN-γ, IL-4 and IFN-γ/IL-4 in the peripheral blood in the observation group were higher than those of the control group (P<0.05). The levels of IFN-γ, IL-4 and IFN-γ/IL-4 in the peripheral blood of patients in the chronic group were higher than those in the acute group. There was no significant difference in IL4, IFN-γ/IL-4 levels between the observation group and the middle ear effusion (P>0.05), IFN-γ levels in peripheral blood were lower than those of the middle ear effusion IFN-γ (P<0.05).Conclusion: Abnormal IFN-γ, IL-4 levels of the peripheral blood and the middle ear effusion have some relationship with secretory otitis media, and Th1/Th2 imbalance may be a risk factor for secretory otitis media.
- otitis media, secretory /
- Th1/Th2 cells imbalances mode /
- IFN-γ /
- IL-4 /
- peripheral blood /
- the middle ear effusion

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