低温等离子翼管神经高选择性分支切断术对变应性鼻炎患者鼻黏膜细胞中血管活性肠肽水平的影响

何平; 金晓杰; 赵辉

doi:10.13201/j.issn.1001-1781.2018.03.002

低温等离子翼管神经高选择性分支切断术对变应性鼻炎患者鼻黏膜细胞中血管活性肠肽水平的影响

- 上海交通大学医学院附属仁济医院南院耳鼻咽喉头颈外科(上海, 201112)
基金项目:
上海交通大学医学院附属仁济医院南院青年项目（No：2015QDQN10）

详细信息

通讯作者: 金晓杰,E-mail:652731684@qq.com

中图分类号: R765.21

收稿日期: 2017-10-09

Effects of highly selective branches neurotomy of vidian nerve with low temperature plasma on vasoactive intestinal peptide in nasal mucosal cells of patients with allergic rhinitis

- Department of Otorhinolaryngology Head and Neck Surgery, South Campus Renji Hospital, School of Medicine, Shanghai Jiao Tong Universtity, Shanghai, 201112, China

More Information

Corresponding author: JIN Xiaojie, E-mail: 652731684@qq.com

Received Date: 09 October 2017

摘要

摘要: 目的：探究低温等离子翼管神经高选择性分支切断术对变应性鼻炎（AR）患者鼻黏膜细胞中血管活性肠肽（VIP）水平的影响。方法：选取我院就诊的AR患者50例作为研究组，同一时间来本院进行鼻中隔矫正术且不伴AR的患者50例作为对照组，对患者施行低温等离子翼管神经高选择性分支切断术，观察鼻黏膜细胞中VIP水平的变化以及临床疗效。结果：研究组患者经过低温等离子翼管神经高选择性分支切断术治疗后，显效28例，治疗效果为64.3%~92.1%，平均（77.4±4.5）%；有效19例，治疗效果为31.2%~56.4%，平均（43.2±2.9）%；仅3例无效，治疗效果均<30%。患者经过治疗后显效+有效组与无效组相比差异有统计学意义（P<0.05）。研究组患者术前和术后VIP光密度值分别为1 723.3±215.4和2 732.3±324.5，两者对比差异有统计学意义（P<0.05）。对照组VIP光密度值为1 855.4±429.3，与研究组术前比较差异有统计学意义（P<0.05），与研究组术后相比差异无统计学意义（P>0.05）。结论：低温等离子翼管神经高选择性分支切断术可以显著降低AR患者鼻黏膜细胞中血管活性肠肽（VIP）水平，缓解患者鼻塞和阵发性喷嚏症状，有效改善预后。
- 低温等离子翼管神经高选择性分支切断术 /
- 鼻炎,变应性 /
- 血管活性肠肽 /
- 疗效分析
Abstract: Objective: The aim of this study is to investigate the effect of highly selective branches neurotomy of vidian nerve with low temperature plasma on the level of vasoactive intestinal peptide in nasal mucosa of patients with allergic rhinitis.Method: Fifty patients with allergic rhinitis were selected as the experimental group. At the same time, 50 normal adults in our hospital were selected as the control group. Highly selective branches neurotomy of vidian nerve with low temperature plasma was performed to observe the changes of vascular intestinal peptide levels in patients with nasal mucosa and the clinical efficacy.Result: Fifty patients with allergic rhinitis were treated with highly selective branches neurotomy of vidian nerve with low temperature plasma. 28 cases have significant effect and the curative effect was 64.3%-92.1% (average was 77.4±4.5)%; 19 were effective and the therapeutic effect was 31.2%-56.4%, with an average of (43.2±2.9)%; only 3 cases were ineffective, and the therapeutic effect was less than 30%. There was significant difference between the two groups after treatment (P<0.05). The optical density of vasoactive intestinal peptide was 1 723.3±215.4 and 2 732.3±324.5 in the preoperative and postoperative groups, respectively, with significant differences (P<0.05). The optical density of vasoactive intestinal peptide in the control group was 1 855.4±429.3, which was significantly different from that in the experimental group before operation (P<0.05). The difference between the control group and the experimental group after operation have no statistically significant (P>0.05).Conclusion: Highly selective branches neurotomy of vidian nerve with low temperature plasma can significantly reduce the level of vasoactive intestinal peptide in nasal mucosa of patients with allergic rhinitis, alleviate the symptoms of nasal congestion and paroxysmal sneezing, and improve the prognosis of patients.
- highly selective branches neurotomy of vidian nerve with low temperature plasma /
- rhinitis, allergic /
- vasoactive intestinal peptide /
- efficacy analysis

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