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Abstract: Exposure to traffic-related air pollutants (TRAP) has been implicated in airway allergic diseases. Recent findings include epidemiologic and mechanistic studies that shed new light on the impact of TRAP on allergic rhinitis (AR) and the biology underlying this impact. These studies have found that oxidative stress induced by TRAP could affect the axis of epithelial cell-dendritic cell-T cell towards a T-helper 2 immune response, which is the major mechanism between TRAP and AR. Further, epigenetics and microRNA might be involved in this process. Our review will summarize the most recent findings in each of these areas.
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[1] CARLSTEN C, RIDER C F.Traffic-related air pollution and allergic disease:an update in the context of global urbanization[J].Curr Opin Allergy Clin Immunol, 2017, 17:85-89.
[2] BRANDT E B, MYERS J M, RYAN P H, et al.Air pollution and allergic diseases[J].Curr Opin Pediatr, 2015, 27:724-735.
[3] JUNG D Y, LEEM J H, KIM H C, et al.Effect of traffic-related air pollution on allergic disease:results of the children's health and environmental research[J].Allergy Asthma Immunol Res, 2015, 7:359-366.
[4] POREBSKI G, WOZNIAK M, CZARNOBILSKA E.Residential proximity to major roadways is associated with increased prevalence of allergic respiratory symptoms in children[J].Ann Agric Environ Med, 2014, 21:760-766.
[5] SHIRINDE J, WICHMANN J, VOYI K.Allergic rhinitis, rhinoconjunctivitis and hayfever symptoms among children are associated with frequency of truck traffic near residences:a cross sectional study[J].Environ Health, 2015, 14:84.
[6] CODISPOTI C D, LEMASTERS G K, LEVIN L, et al.Traffic pollution is associated with early childhood aeroallergen sensitization[J].Ann Allergy Asthma Immunol, 2015, 114:126-133.
[7] DENG Q, LU C, YU Y, et al.Early life exposure to traffic-related air pollution and allergic rhinitis in preschool children[J].Respir Med, 2016, 121:67-73.
[8] DENG Q, LU C, LI Y, et al.Exposure to outdoor air pollution during trimesters of pregnancy and childhood asthma, allergic rhinitis, and eczema[J].Environ Res, 2016, 150:119-127.
[9] TENG B, ZHANG X, YI C, et al.The association between ambient air pollution and allergic rhinitis:further epidemiological evidence from Changchun, Northeastern China[J].Int J Environ Res Public Health, 2017, 14.
[10] WANG I J, TUNG T H, TANG C S, et al.Allergens, air pollutants, and childhood allergic diseases[J].Int J Hyg Environ Health, 2016, 219:66-71.
[11] ACCIANI T H, BRANDT E B, KHURANA H G, et al.Diesel exhaust particle exposure increases severity of allergic asthma in young mice[J].Clin Exp Allergy, 2013, 43:1406-1418.
[12] CHUNG H Y, HSIEH C J, TSENG C C, et al.Association between the first occurrence of allergic rhinitis in preschool children and air pollution in Taiwan[J].Int J Environ Res Public Health, 2016, 13.
[13] PEDEN D B.The role of oxidative stress and innate immunity in O (3) and endotoxin-induced human allergic airway disease[J].Immunol Rev, 2011, 242:91-105.
[14] ALTUG H, GAGA E O, DOGEROGLU T, et al.Effects of air pollution on lung function and symptoms of asthma, rhinitis and eczema in primary school children[J].Environ Sci Pollut Res Int, 2013, 20:6455-6467.
[15] ALEXIS N E, CARLSTEN C.Interplay of air pollution and asthma immunopathogenesis:a focused review of diesel exhaust and ozone[J].Int Immunopharmacol, 2014, 23:347-355.
[16] DIAZ-SANCHEZ D, GARCIA M P, WANG M, et al.Nasal challenge with diesel exhaust particles can induce sensitization to a neoallergen in the human mucosa[J].JAllergy Clin Immunol, 1999, 104:1183-1188.
[17] GILLILAND F D, LI Y F, SAXON A, et al.Effect of glutathione-S-transferase M1and P1genotypes on xenobiotic enhancement of allergic responses:randomised, placebo-controlled crossover study[J].Lancet, 2004, 363:119-125.
[18] LI N, BUGLAK N.Convergence of air pollutant-induced redox-sensitive signals in the dendritic cells contributes to asthma pathogenesis[J].Toxicol Lett, 2015, 237:55-60.
[19] JENG H A.Chemical composition of ambient particulate matter and redox activity[J].Environ Monit Assess, 2010, 169:597-606.
[20] DENG X, RUI W, ZHANG F, et al.PM2.5induces Nrf2-mediated defense mechanisms against oxidative stress by activating PIK3/AKT signaling pathway in human lung alveolar epithelial A549cells[J].Cell Biol Toxicol, 2013, 29:143-157.
[21] SHINKAI Y, NAKAJIMA S, EIGUREN-FERNANDEZA, et al.Ambient vapor samples activate the Nrf2-AREpathway in human bronchial epithelial BEAS-2B cells[J].Environ Toxicol, 2014, 29:1292-1300.
[22] LI Y J, KAWADA T, AZUMA A.Nrf2 is a protective factor against oxidative stresses induced by diesel exhaust particle in allergic asthma[J].Oxid Med Cell Longev, 2013, 2013:323607.
[23] BLECK B, TSE D B, CUROTTO DE LAFAILLE MA, et al.Diesel exhaust particle-exposed human bronchial epithelial cells induce dendritic cell maturation and polarization via thymic stromal lymphopoietin[J].J Clin Immunol, 2008, 28:147-156.
[24] BLECK B, TSE D B, GORDON T, et al.Diesel exhaust particle-treated human bronchial epithelial cells upregulate Jagged-1and OX40 ligand in myeloid dendritic cells via thymic stromal lymphopoietin[J].J Immunol, 2010, 185:6636-6645.
[25] LAMBRECHT B N, HAMMAD H.The airway epithelium in asthma[J].Nat Med, 2012, 18:684-692.
[26] LI N, WANG M, BARAJAS B, et al.Nrf2deficiency in dendritic cells enhances the adjuvant effect of ambient ultrafine particles on allergic sensitization[J].J Innate Immun, 2013, 5:543-554.
[27] WILLIAMS M A, RANGASAMY T, BAUER S M, et al.Disruption of the transcription factor Nrf2 promotes pro-oxidative dendritic cells that stimulate Th2-like immunoresponsiveness upon activation by ambient particulate matter[J].J Immunol, 2008, 181:4545-4559.
[28] XIA M, VIERA-HUTCHINS L, GARCIA-LLORETM, et al.Vehicular exhaust particles promote allergic airway inflammation through an aryl hydrocarbon receptor-notch signaling cascade[J].J Allergy Clin Immunol, 2015, 136:441-453.
[29] LIU J, BALLANEY M, AL-ALEM U, et al.Combined inhaled diesel exhaust particles and allergen exposure alter methylation of T helper genes and IgEproduction in vivo[J].Toxicol Sci, 2008, 102:76-81.
[30] HEW K M, WALKER A I, KOHLI A, et al.Childhood exposure to ambient polycyclic aromatic hydrocarbons is linked to epigenetic modifications and impaired systemic immunity in T cells[J].Clin Exp Allergy, 2015, 45:238-248.
[31] JARDIM M J, FRY R C, JASPERS I, et al.Disruption of microRNA expression in human airway cells by diesel exhaust particles is linked to tumorigenesisassociated pathways[J].Environ Health Perspect, 2009, 117:1745-1751.
[32] BLECK B, GRUNIG G, CHIU A, et al.MicroRNA-375regulation of thymic stromal lymphopoietin by diesel exhaust particles and ambient particulate matter in human bronchial epithelial cells[J].J Immunol, 2013, 190:3757-3763.
[33] RADMAN M, GOLSHIRI A, SHAMSIZADEH A, et al.Toll-like receptor 4plays significant roles during allergic rhinitis[J].Allergol Immunopathol (Madr), 2015, 43:416-420.
[34] JEONG E, LEE J Y.Intrinsic and extrinsic regulation of innate immune receptors[J].Yonsei Med J, 2011, 52:379-392.
[35] MU H H, HASEBE A, VAN SCHELT A, et al.Novel interactions of a microbial superantigen with TLR2 and TLR4 differentially regulate IL-17 and Th17-associated cytokines[J].Cell Microbiol, 2011, 13:374-387.
[36] OAKES J L, O'CONNOR B P, WARG L A, et al.O-zone enhances pulmonary innate immune response to a Toll-like receptor-2agonist[J].Am J Respir Cell Mol Biol, 2013, 48:27-34.
[37] CONNOR A J, LASKIN J D, LASKIN D L.Ozoneinduced lung injury and sterile inflammation.Role of toll-like receptor 4[J].Exp Mol Pathol, 2012, 92:229-235.
[38] MIYATA R, VAN EEDEN S F.The innate and adaptive immune response induced by alveolar macrophages exposed to ambient particulate matter[J].Toxicol Appl Pharmacol, 2011, 257:209-226.
[39] OHTANI T, NAKAGAWA S, KUROSAWA M, et al.Cellular basis of the role of diesel exhaust particles in inducing Th2-dominant response[J].J Immunol, 2005, 174:2412-2419.
[40] DE GROVE K C, PROVOOST S, HENDRIKS RW, et al.Dysregulation of type 2innate lymphoid cells and TH2 cells impairs pollutant-induced allergic airway responses[J].J Allergy Clin Immunol, 2017, 139:246-257.
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